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E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Additionally we are shipping HACE1 Antibodies (27) and HACE1 Kits (8) and many more products for this protein.
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Hepatocellular carcinoma patients with low HACE1 expression levels exhibited poorer overall survival and HACE1 was found to be an independent prognostic factor for survival.
HACE1 as a specific E3 ligase that polyubiquitinates YB-1 through non-canonical K27 linked ubiquitin chains.
Biallelic loss-of-function mutations in HACE1 are associated with an autosomal recessive neurodevelopmental syndrome.
supports a critical role for HACE1 in breast cancer progression and identifies patients that may benefit from Rac (show AKT1 Proteins)-targeted therapies
contrary to previous report, overexpression of HACE1 by transduction of recombinant protein did not affect proliferation or survival of NKTCL cell lines. We therefore conclude that HACE1 is not directly involved in NKTCL pathophysiology
HACE1-OPTN (show OPTN Proteins) axis synergistically suppresses growth and tumorigenicity of lung cancer cells.
Ubiquitylation and activation of RAB11a (show RAB11A Proteins) is promoted by a beta2 adrenergic receptor (show ADRB2 Proteins)-HACE1 complex.
HACE1 reduces oxidative stress and mutant Huntingtin (show HTT Proteins) toxicity by promoting the NRF2 (show GABPA Proteins) response.
All stages of HCCs (show HCCS Proteins) presented HACE1 methylation, indicating that the HACE1 gene has been methylated from the early stages of HCCs (show HCCS Proteins).
HACE1 is tumor suppressor gene located within the 6q21 region, and loss of function of multiple tumor suppressor genes within 6q21 may be a critical determinant of NK cell lymphomagenesis.
Increased reactive oxygen species (ROS (show ROS1 Proteins)) production due to Hace1 loss leads to glutamine (show GFPT1 Proteins) addiction as a mechanism to cope with increased ROS (show ROS1 Proteins)-induced oxidative stress.
Data indicate that HECT E3 ubiquitin ligase (show MUL1 Proteins) HACE1 deficiency accelerates pressure overload-induced heart failure.
Hace1 controls ROS (show ROS1 Proteins) generation of vertebrate Rac1-dependent NADPH oxidase (show NOX1 Proteins) complexes.
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB (By similarity).
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
, E3 ubiquitin-protein ligase HACE1
, HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1
, E3 ubiquitin-protein ligase HACE1-like
, e3 ubiquitin-protein ligase HACE1-like