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HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). Additionally we are shipping HERC6 Proteins (4) and many more products for this protein.
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HERC6 ancestor emerged in nematodes and that the family expanded throughout evolution. The mRNA expression pattern was found to be diverse in selected tissues and cells
These results suggest that in addition to promoting protein ISGylation, Herc6 has a novel and protein ISGylation-independent function in the male reproductive system.
Data show that the HerC6 N-terminal RCC1 (show RCC1 Antibodies)-like domain (RLD) allows ISG15 (show ISG15 Antibodies) conjugation.
mHERC6 is essential for endogenous murine ISGylation and thus represents the dominant ISG15 (show ISG15 Antibodies) E3 ligase in mice.
Expression of the Herc5-mediated ubiquitin-like protein ISGylation system can distinctly potentiate interferon-beta (show IFNB1 Antibodies)-induced antiviral effects against influenza A virus.
HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005
HECT domain and RCC1-like domain-containing protein 6
, hect domain and RLD 6
, potential ubiquitin ligase
, probable E3 ubiquitin-protein ligase HERC6
, E3 ISG15--protein ligase Herc6
, hect domain and RLD 5