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HESX Homeobox 1 Proteins (HESX1)

HESX1 encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Additionally we are shipping HESX Homeobox 1 Antibodies (23) and HESX Homeobox 1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HESX1 8820 Q9UBX0
Rat HESX1 HESX1 498575  
HESX1 15209 Q61658
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Top HESX Homeobox 1 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,409.00
Details
Yeast Pan paniscus His tag   1 mg Log in to see 56 to 66 Days
$2,440.17
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$2,440.17
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,442.00
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,473.17
Details

HESX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for HESX Homeobox 1 (HESX1) Interaction Partners

Human HESX Homeobox 1 (HESX1) interaction partners

  1. A novel heterozygous mutation in the HESX1 gene and a novel homozygous mutation in the PROP1 (show PROP1 Proteins) gene were detected in 2 pedigrees with combined pituitary hormone (show CGA Proteins) deficiency

  2. investigated the specific mutations in PROP1 (show PROP1 Proteins), POU1F1 (show POU1F1 Proteins), LHX3 (show LHX3 Proteins), and HESX1 genes in patients with combined pituitary hormone (show CGA Proteins) deficiency (CPHD) in Turkey

  3. Data indicate that HESX1, LHX4 (show LHX4 Proteins) and SOX3 (show SOX3 Proteins) polymorphisms may be associated with pituitary stalk interruption syndrome (PSIS).

  4. expand the phenotypic spectrum of HESX1 mutations in Kallman syndrome.

  5. Data show no mutations in HESX1, PROP1 (show PROP1 Proteins), and POU1F1 (show POU1F1 Proteins) genes, seven different mutations in CTNNB1 (show CTNNB1 Proteins) in 8/16 patients, and hyperexpression of miR (show MLXIP Proteins)-150.

  6. A c.357+3G>A mutation prevents the generation of one of the alternative isoforms normally produced by the wild-type allele, predicting a truncated HESX1 protein.

  7. A novel HESX1 causative mutation was found in a consanguineous family, and two LHX4 (show LHX4 Proteins) mutations were present in familial Pituitary stalk interruption syndrome.

  8. Mutations in the PROP1 (show PROP1 Proteins) and HESX1 genes were not identified in these patients with sporadic growth hormone (show GH1 Proteins) defiency, combined pituitary hormone (show CGA Proteins) deficiency and septo-optic dysplasia.

  9. A large cohort of patients with schizencephaly, some with features of septo-optic dysplasia, were sequenced for mutations in LHX2 (show LHX2 Proteins), HESX1 and SOX2 (show SOX2 Proteins).

  10. Studies suggest that TLE1 (show TLE1 Proteins) and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1 (show PROP1 Proteins).

Mouse (Murine) HESX Homeobox 1 (HESX1) interaction partners

  1. Hesx1 plays a significant role in sustaining pluripotency in embryonic stem cells.Hesx1 transcriptionally suppresses differentiation-related genes.

  2. Wnt (show WNT2 Proteins) inhibition during the first day has larger impact on the activation of Hesx1 and Six3, suggesting that in embryos Wnt (show WNT2 Proteins) inhibition caused by Dkk1 (show DKK1 Proteins) contributes greatly in the establishment of the anterior forebrain precursor.

  3. Variability in Hes1 expression therefore helps to explain why STAT3 (show STAT3 Proteins) responsiveness varies between individual ES cells, and this in turn helps to explain why pluripotent cells commit to differentiate asynchronously..

  4. Transcriptional profiling of anterior forebrain precursors from mouse embryos expressing eGFP from the Hesx1 locus provides molecular evidence supporting a novel function of Hesx1 in mediating repression of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) target activation.

  5. Studies suggest that TLE1 (show TLE1 Proteins) and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1 (show PROP1 Proteins).

  6. Data suggest that formation of a heterodimer between HESX1 and PROP1 (show PROP1 Proteins) allows HESX1 to become active, and that PROP1 (show PROP1 Proteins) then replaces HESX1 to advance to the middle stage of pituitary development.

  7. A novel inducible element, activated by contact with Rathke's pouch, is present in the regulatory region of the Hesx1 homeobox (show PRRX1 Proteins) gene.

  8. the domains of Hes-1 needed to block adipogenesis coincide with those necessary for transcriptional repression.

  9. Conserved regulatory elements establish the dynamic expression of Rpx in early development.

  10. The absence of Hesx1 leads to a posterior transformation of the anterior forebrain (AFB) during mouse development.

HESX Homeobox 1 (HESX1) Protein Profile

Protein Summary

This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency.

Gene names and symbols associated with HESX Homeobox 1 Proteins (HESX1)

  • HESX homeobox 1 (HESX1)
  • HESX homeobox 1 (LOC100351827)
  • HESX homeobox 1 (Hesx1)
  • homeobox gene expressed in ES cells (Hesx1)
  • homeodomain-containing protein (ANF)
  • ANF protein
  • CPHD5 protein
  • HES-1 protein
  • HESX1 protein
  • RGD1563858 protein
  • Rpx protein

Protein level used designations for HESX Homeobox 1 Proteins (HESX1)

Rathke pouch homeobox , hAnf , homeobox expressed in ES cells 1 , homeobox protein ANF , homeobox, ES cell expressed 1 , homeo box (expressed in ES cells) 1 , homeo box gene expressed in ES cells , anterior-restricted homeobox protein , rathke pouch homeo box

GENE ID SPECIES
8820 Homo sapiens
100351827 Oryctolagus cuniculus
100967444 Pan paniscus
747229 Pan troglodytes
498575 Rattus norvegicus
15209 Mus musculus
100008708 Oryctolagus cuniculus
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