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HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) ELISA Kits

HIRA encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Additionally we are shipping HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) Antibodies (59) and HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat HIRA HIRA 363849  
Anti-Mouse HIRA HIRA 15260 Q61666
Anti-Human HIRA HIRA 7290 P54198
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More ELISA Kits for HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) Interaction Partners

Mouse (Murine) HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) interaction partners

  1. Data show that Hira is important to mediates Histone H3 (show HIST3H3 ELISA Kits)/H4 replacement during mouse oogenesis which is required for normal 5mC deposition in oocytes. Its loss results in chromatin abnormalities and extensive oocyte loss.

  2. HIRA is not only critical for beta-globin (show HBB ELISA Kits) expression but is also required for activation of the erythropoietic regulators EKLF (show KLF1 ELISA Kits) and GATA binding protein 1 (GATA1).

  3. Hira-mediated H3.3 incorporation is essential for parental genome reprogramming and reveal an unexpected role for rRNA transcription in the mouse zygote

  4. WHSC1 (show WHSC1 ELISA Kits) links transcription elongation to HIRA-mediated histone H3.3 (show H3F3A ELISA Kits) deposition.

  5. HIRA interacts with H3.3/H4 in the absence of Daxx (show DAXX ELISA Kits).

  6. HIRA is an essential factor for muscle development by establishing MyoD (show MYOD1 ELISA Kits) activation in myotubes.

  7. Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality

Human HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) interaction partners

  1. HIRA controls a specialized, dynamic H4K16ac-decorated chromatin landscape in senescent cells and enforces tumor suppression.

  2. Mechanistic studies reveal that HIRA accumulates at sites of UVC irradiation upon detection of DNA damage prior to repair and deposits newly synthesized H3.3 histones. This local action of HIRA depends on ubiquitylation events associated with damage recognition.

  3. HIRA is required for deposition of histone H3.3 (show H3F3A ELISA Kits) at its binding sites.

  4. NHRD domain of UBN1 as being an essential region for HIRA interaction and chromatin organization by the HUCA complex

  5. HIRA plays a unique, ASF1a (show ASF1A ELISA Kits)-independent role, which is required for the localization of HP1 (show DEFA1 ELISA Kits)

  6. Data show that, like HIRA, UBN1, and ASF1a (show ASF1A ELISA Kits), CABIN1 (show CABIN1 ELISA Kits) is involved in heterochromatinization of the genome of senescent human cells.

  7. phosphorylation of histone H4 Ser 47 catalyzed by the PAK2 kinase, promotes nucleosome assembly of H3.3-H4 and inhibits nucleosome assembly of H3.1-H4 by increasing the binding affinity of HIRA to H3.3-H4 and reducing association of CAF-1 with H3.1-H4

  8. the N-terminal half of HIRA should contribute positively to the growth rate via up-regulation of a set of cell cycle-related genes, whereas the C-terminal half down-regulated another set of them without exhibiting any effect on the cell growth

  9. The N- and C-terminal regions of ASF1a (show ASF1A ELISA Kits) and ASF1b (show ASF1B ELISA Kits) determine the different affinities of these two proteins for HIRA, by contacting regions outside the HIRA B domain. CAF-1 (show CHAF1B ELISA Kits) also uses B domain-like motifs for binding to ASF1a (show ASF1A ELISA Kits), thereby competing with HIRA.

  10. Hpc2 (show ELAC2 ELISA Kits)-related domain of UBN1, UBN2, and Hpc2p is an evolutionarily conserved HIRA/Hir (show KCNJ4 ELISA Kits)-binding domain, which directly interacts with the N-terminal WD repeats of HIRA/Hir (show KCNJ4 ELISA Kits).

Xenopus laevis HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) interaction partners

  1. Downregulation of the H3.3 histone chaperone HIRA similarly impairs late gastrulation.

Arabidopsis thaliana HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) interaction partners

  1. Loss of HIRA reduces extractable histone H3 protein levels and decreases nucleosome occupancy at both actively transcribed genes and heterochromatic regions.

HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) Antigen Profile

Antigen Summary

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Gene names and symbols associated with HIRA

  • HIR histone cell cycle regulation defective homolog A (S. cerevisiae) (HIRA) antibody
  • HIR histone cell cycle regulation defective homolog A (S. cerevisiae) (hira) antibody
  • HIR histone cell cycle regulation defective homolog A (S. cerevisiae) (Hira) antibody
  • HIRA (LOC732736) antibody
  • histone cell cycle regulation defective homolog A (S. cerevisiae) (Hira) antibody
  • histone cell cycle regulator (HIRA) antibody
  • histone cell cycle regulator (hira) antibody
  • protein HIRA (HIRA) antibody
  • Tuple1/HirA (hira) antibody
  • AA138857 antibody
  • D16Ertd95e antibody
  • dgcr1 antibody
  • HIRA antibody
  • hira-A antibody
  • homolog of histone chaperone HIRA antibody
  • N28177 antibody
  • si:ch211-188g24.3 antibody
  • tup1 antibody
  • tuple1 antibody
  • wu:fb97b07 antibody
  • wu:fi43b08 antibody

Protein level used designations for HIRA

HIR histone cell cycle regulation defective homolog A (S. cerevisiae) , fb97b07 , HIR histone cell cycle regulation defective homolog A-like , protein HIRA-like , histone cell cycle regulation defective homolog A , protein HIRA , TUP1-like enhancer of split protein 1 , cHIRA , histone regulator protein , TUP1-like enhancer of split gene 1 , DiGeorge critical region gene 1 , HIR histone cell cycle regulation defective homolog A

GENE ID SPECIES
470138 Pan troglodytes
568076 Danio rerio
100052845 Equus caballus
100352472 Oryctolagus cuniculus
100368021 Saccoglossus kowalevskii
100407742 Callithrix jacchus
100450459 Pongo abelii
100467668 Ailuropoda melanoleuca
100581135 Nomascus leucogenys
486424 Canis lupus familiaris
100153131 Sus scrofa
511514 Bos taurus
363849 Rattus norvegicus
374074 Gallus gallus
732736 Zea mays
15260 Mus musculus
7290 Homo sapiens
394341 Xenopus laevis
823578 Arabidopsis thaliana
446054 Takifugu rubripes
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