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HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) Proteins (HIRA)

HIRA encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Additionally we are shipping HIRA Antibodies (61) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat HIRA HIRA 363849  
HIRA 15260 Q61666
HIRA 7290 P54198
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Top HIRA Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human GST tag   100 μg Log in to see 14 to 16 Days
$444.68
Details

HIRA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) Interaction Partners

Mouse (Murine) HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) interaction partners

  1. Data show that Hira is important to mediates Histone H3 (show HIST3H3 Proteins)/H4 replacement during mouse oogenesis which is required for normal 5mC deposition in oocytes. Its loss results in chromatin abnormalities and extensive oocyte loss.

  2. HIRA is not only critical for beta-globin (show HBB Proteins) expression but is also required for activation of the erythropoietic regulators EKLF (show KLF1 Proteins) and GATA binding protein 1 (GATA1).

  3. Hira-mediated H3.3 incorporation is essential for parental genome reprogramming and reveal an unexpected role for rRNA transcription in the mouse zygote

  4. WHSC1 (show WHSC1 Proteins) links transcription elongation to HIRA-mediated histone H3.3 (show H3F3A Proteins) deposition.

  5. HIRA interacts with H3.3/H4 in the absence of Daxx (show DAXX Proteins).

  6. HIRA is an essential factor for muscle development by establishing MyoD (show MYOD1 Proteins) activation in myotubes.

  7. Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality

Human HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) interaction partners

  1. HIRA controls a specialized, dynamic H4K16ac-decorated chromatin landscape in senescent cells and enforces tumor suppression.

  2. Mechanistic studies reveal that HIRA accumulates at sites of UVC irradiation upon detection of DNA damage prior to repair and deposits newly synthesized H3.3 histones. This local action of HIRA depends on ubiquitylation events associated with damage recognition.

  3. HIRA is required for deposition of histone H3.3 (show H3F3A Proteins) at its binding sites.

  4. NHRD domain of UBN1 as being an essential region for HIRA interaction and chromatin organization by the HUCA complex

  5. HIRA plays a unique, ASF1a (show ASF1A Proteins)-independent role, which is required for the localization of HP1 (show DEFA1 Proteins)

  6. Data show that, like HIRA, UBN1, and ASF1a, CABIN1 is involved in heterochromatinization of the genome of senescent human cells.

  7. phosphorylation of histone H4 Ser 47 catalyzed by the PAK2 kinase, promotes nucleosome assembly of H3.3-H4 and inhibits nucleosome assembly of H3.1-H4 by increasing the binding affinity of HIRA to H3.3-H4 and reducing association of CAF-1 with H3.1-H4

  8. the N-terminal half of HIRA should contribute positively to the growth rate via up-regulation of a set of cell cycle-related genes, whereas the C-terminal half down-regulated another set of them without exhibiting any effect on the cell growth

  9. The N- and C-terminal regions of ASF1a (show ASF1A Proteins) and ASF1b (show ASF1B Proteins) determine the different affinities of these two proteins for HIRA, by contacting regions outside the HIRA B domain. CAF-1 (show CHAF1B Proteins) also uses B domain-like motifs for binding to ASF1a (show ASF1A Proteins), thereby competing with HIRA.

  10. Hpc2 (show ELAC2 Proteins)-related domain of UBN1, UBN2, and Hpc2p is an evolutionarily conserved HIRA/Hir (show KCNJ4 Proteins)-binding domain, which directly interacts with the N-terminal WD repeats of HIRA/Hir (show KCNJ4 Proteins).

Xenopus laevis HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) interaction partners

  1. Downregulation of the H3.3 histone chaperone HIRA similarly impairs late gastrulation.

Arabidopsis thaliana HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) interaction partners

  1. Loss of HIRA reduces extractable histone H3 protein levels and decreases nucleosome occupancy at both actively transcribed genes and heterochromatic regions.

HIRA Protein Profile

Protein Summary

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Gene names and symbols associated with HIRA

  • HIR histone cell cycle regulation defective homolog A (S. cerevisiae) (HIRA)
  • HIR histone cell cycle regulation defective homolog A (S. cerevisiae) (hira)
  • HIR histone cell cycle regulation defective homolog A (S. cerevisiae) (Hira)
  • HIRA (LOC732736)
  • histone cell cycle regulation defective homolog A (S. cerevisiae) (Hira)
  • histone cell cycle regulator (HIRA)
  • histone cell cycle regulator (hira)
  • protein HIRA (HIRA)
  • Tuple1/HirA (hira)
  • AA138857 protein
  • D16Ertd95e protein
  • dgcr1 protein
  • HIRA protein
  • hira-A protein
  • homolog of histone chaperone HIRA protein
  • N28177 protein
  • si:ch211-188g24.3 protein
  • tup1 protein
  • tuple1 protein
  • wu:fb97b07 protein
  • wu:fi43b08 protein

Protein level used designations for HIRA

HIR histone cell cycle regulation defective homolog A (S. cerevisiae) , fb97b07 , HIR histone cell cycle regulation defective homolog A-like , protein HIRA-like , histone cell cycle regulation defective homolog A , protein HIRA , TUP1-like enhancer of split protein 1 , cHIRA , histone regulator protein , TUP1-like enhancer of split gene 1 , DiGeorge critical region gene 1 , HIR histone cell cycle regulation defective homolog A

GENE ID SPECIES
470138 Pan troglodytes
568076 Danio rerio
100052845 Equus caballus
100352472 Oryctolagus cuniculus
100368021 Saccoglossus kowalevskii
100407742 Callithrix jacchus
100450459 Pongo abelii
100467668 Ailuropoda melanoleuca
100581135 Nomascus leucogenys
486424 Canis lupus familiaris
100153131 Sus scrofa
511514 Bos taurus
363849 Rattus norvegicus
374074 Gallus gallus
732736 Zea mays
15260 Mus musculus
7290 Homo sapiens
394341 Xenopus laevis
823578 Arabidopsis thaliana
446054 Takifugu rubripes
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