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The protein encoded by CD74 associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. Additionally we are shipping CD74 Kits (19) and CD74 Proteins (15) and many more products for this protein.
Showing 10 out of 436 products:
Human Monoclonal CD74 Primary Antibody for ICC, FACS - ABIN361789
Barrera, Beswick, Sierra, Bland, Espejo, Mifflin, Adegboyega, Crowe, Ernst, Reyes: Polarized expression of CD74 by gastric epithelial cells. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005
Show all 8 references for ABIN361789
Human Monoclonal CD74 Primary Antibody for IHC (fro), IF - ABIN263955
Becker-Herman, Arie, Medvedovsky, Kerem, Shachar: CD74 is a member of the regulated intramembrane proteolysis-processed protein family. in Molecular biology of the cell 2005
Show all 6 references for ABIN263955
Human Monoclonal CD74 Primary Antibody for FACS - ABIN2662681
Beswick, Pinchuk, Minch, Suarez, Sierra, Yamaoka, Reyes: The Helicobacter pylori urease B subunit binds to CD74 on gastric epithelial cells and induces NF-kappaB activation and interleukin-8 production. in Infection and immunity 2006
Show all 5 references for ABIN2662681
Human Monoclonal CD74 Primary Antibody for WB - ABIN1944838
Claesson, Larhammar, Rask, Peterson: cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure. in Proceedings of the National Academy of Sciences of the United States of America 1984
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Human Monoclonal CD74 Primary Antibody for FACS, ELISA - ABIN1724870
Tian, Zhang, Li, Liu, Dong: CD74: a potential novel target for triple-negative breast cancer. in Tumour biology 2012
Show all 2 references for ABIN1724870
Human Monoclonal CD74 Primary Antibody for ICC, FACS - ABIN1724871
Zheng, Yang, Rong, Yuan, Ma, Wang, Shen, Cui: CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer. in World journal of gastroenterology : WJG 2012
Show all 2 references for ABIN1724871
Human Monoclonal CD74 Primary Antibody for ICC, FACS - ABIN2481709
Denzin, Robbins, Carboy-Newcomb, Cresswell: Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. in Immunity 1995
Human Monoclonal CD74 Primary Antibody for FACS - ABIN316495
Wraight, van Endert, Möller, Lipp, Ling, MacLennan, Koch, Moldenhauer: Human major histocompatibility complex class II invariant chain is expressed on the cell surface. in The Journal of biological chemistry 1990
Data show that cathepsins S (CatS) regulates CCL2 (show CCL2 Antibodies) chemokine (show CCL1 Antibodies) expression by modulation of CD74 antigen processing.
Suggest that the DQA1*0103/CD74 dimer may result in presentation of unique antigens and susceptibility to develop arthritis.
CD74 plays a critical role in the MIF (show MIF Antibodies) inhibition of osteoclastogenesis.
Genetic deletion of CD74 restored the ability of infected dendritic cells to present a parasite antigen in the context of MHC-II.
SPPL2a (show SPPL2A Antibodies)-mediated processing of CD74 NTF (show TNF Antibodies) is indispensable to maintain appropriate levels of tonic BCR (show BCR Antibodies) signaling to promote B cell maturation (show TNFRSF17 Antibodies).
Results support the hypothesis that neurodegeneration following traumatic brain injury is dependent upon antigen processing and presentation that requires CD74
Methylglyoxal induced gene expression of CD74 in the in the diabetic retina.
In TPA (show PLAT Antibodies)-induced skin inflammation, MIF (show MIF Antibodies) is released from damaged keratinocytes and then triggers the chemotaxis of CD74(+)CXCR2 (show CXCR2 Antibodies)(+) NKT (show CTSL1 Antibodies) cells for IFN-gamma (show IFNG Antibodies) production.
MIF (show MIF Antibodies) promotes the migration of B cells through a ZAP-70 (show ZAP70 Antibodies)-dependent pathway mediated by cooperative engagement of CXCR4 (show CXCR4 Antibodies) and CD74.
These results demonstrate natural antagonist activity of DRalpha1 for macrophage migration inhibitory factor (show MIF Antibodies)
predicted binding of one CD74 trimer to a single RTL1000 antagonist utilized the same two 5 residue determinants
an inverse correlation with the tumor size for stromal MIF (show AMH Antibodies) and a positive correlation with the triple receptor negative tumor status for stromal CD74 seem to be showed
Studies indicate that the invariant chain (CD74) is critical for antigen presentation.
FOXP1 (show FOXP1 Antibodies) represents a novel regulator of genes targeted by the class II MHC (show HLAE Antibodies) transactivator CIITA (show CIITA Antibodies) and CD74.
Interferon gamma (show IFNG Antibodies) promotes melanoma cell survival regulating CD74-MIF (show AMH Antibodies) interaction.
The results of this stusy suggested that the CD74 represents a positive prognostic marker most probably because of its association with an M1-polarized immune milieu in high-grade gliomas.
Invariant chain is a new chaperone for TLR7 (show TLR7 Antibodies) in B cells. (Review)
CD74 expression and its therapeutic potential in thyroid carcinoma
Specific targeting of the CD74 on the lymphoma cell surface will sensitize CD74-expressing cancer cells to Fas (show FAS Antibodies)-mediated apoptosis.
A conserved WW domain (show DRP2 Antibodies)-like motif regulates CD74 antigen-dependent cell-surface transport of the NKG2D (show KLRK1 Antibodies) ligand ULBP2 (show ULBP2 Antibodies).
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
H-2 class II histocompatibility antigen gamma chain
, Ia-associated invariant chain
, MHC class II-associated invariant chain
, class II-associated invariant chain peptide
, dinucleotide microsatellite
, histocompatibility: class II antigens, gamma chain of
, ia antigen-associated invariant chain
, invariant polypeptide of major histocompatibility complex, class II antigen-associated
, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
, HLA class II histocompatibility antigen gamma chain
, HLA-DR antigens-associated invariant chain
, MHC HLA-DR gamma chain
, gamma chain of class II antigens