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HLA-DR-gamma Proteins (CD74)

The protein encoded by CD74 associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. Additionally we are shipping CD74 Antibodies (431) and CD74 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CD74 16149 P04441
CD74 972 P04233
Rat CD74 CD74 25599 P10247
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Top CD74 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$330.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_HEK-293 Human His tag 50 μg Log in to see 2 to 3 Days
$651.00
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$584.38
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details

CD74 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
, ,
Human , , , , , ,
, ,

Top referenced CD74 Proteins

  1. Human CD74 Protein expressed in Human Cells - ABIN2003968 : Henne, Schwenk, Koch, Möller: Surface expression of the invariant chain (CD74) is independent of concomitant expression of major histocompatibility complex class II antigens. in Immunology 1995 (PubMed)
    Show all 5 references for ABIN2003968

  2. Human CD74 Protein expressed in HEK-293 Cells - ABIN2180835 : Scanlon: The evolution of surgical oncology. Presidential address: James Ewing society, New Orleans, 1975. in Cancer 1976 (PubMed)
    Show all 3 references for ABIN2180835

  3. Human CD74 Protein expressed in Wheat germ - ABIN1348699 : Baerlecken, Nothdorft, Stummvoll, Sieper, Rudwaleit, Reuter, Matthias, Schmidt, Witte: Autoantibodies against CD74 in spondyloarthritis. in Annals of the rheumatic diseases 2014 (PubMed)

More Proteins for HLA-DR-gamma (CD74) Interaction Partners

Mouse (Murine) HLA-DR-gamma (CD74) interaction partners

  1. Data show that cathepsins S (CatS) regulates CCL2 (show CCL2 Proteins) chemokine (show CCL1 Proteins) expression by modulation of CD74 antigen processing.

  2. Suggest that the DQA1*0103/CD74 dimer may result in presentation of unique antigens and susceptibility to develop arthritis.

  3. CD74 plays a critical role in the MIF (show MIF Proteins) inhibition of osteoclastogenesis.

  4. Genetic deletion of CD74 restored the ability of infected dendritic cells to present a parasite antigen in the context of MHC-II.

  5. SPPL2a (show SPPL2A Proteins)-mediated processing of CD74 NTF (show TNF Proteins) is indispensable to maintain appropriate levels of tonic BCR (show BCR Proteins) signaling to promote B cell maturation (show TNFRSF17 Proteins).

  6. Results support the hypothesis that neurodegeneration following traumatic brain injury is dependent upon antigen processing and presentation that requires CD74

  7. Methylglyoxal induced gene expression of CD74 in the in the diabetic retina.

  8. In TPA (show PLAT Proteins)-induced skin inflammation, MIF (show MIF Proteins) is released from damaged keratinocytes and then triggers the chemotaxis of CD74(+)CXCR2 (show CXCR2 Proteins)(+) NKT (show CTSL1 Proteins) cells for IFN-gamma (show IFNG Proteins) production.

  9. MIF (show MIF Proteins) promotes the migration of B cells through a ZAP-70 (show ZAP70 Proteins)-dependent pathway mediated by cooperative engagement of CXCR4 (show CXCR4 Proteins) and CD74.

  10. These results demonstrate natural antagonist activity of DRalpha1 for macrophage migration inhibitory factor (show MIF Proteins)

Human HLA-DR-gamma (CD74) interaction partners

  1. an inverse correlation with the tumor size for stromal MIF (show AMH Proteins) and a positive correlation with the triple receptor negative tumor status for stromal CD74 seem to be showed

  2. Studies indicate that the invariant chain (CD74) is critical for antigen presentation.

  3. FOXP1 (show FOXP1 Proteins) represents a novel regulator of genes targeted by the class II MHC (show HLAE Proteins) transactivator CIITA (show CIITA Proteins) and CD74.

  4. Interferon gamma (show IFNG Proteins) promotes melanoma cell survival regulating CD74-MIF (show AMH Proteins) interaction.

  5. The results of this stusy suggested that the CD74 represents a positive prognostic marker most probably because of its association with an M1-polarized immune milieu in high-grade gliomas.

  6. Invariant chain is a new chaperone for TLR7 (show TLR7 Proteins) in B cells. (Review)

  7. CD74 expression and its therapeutic potential in thyroid carcinoma

  8. Specific targeting of the CD74 on the lymphoma cell surface will sensitize CD74-expressing cancer cells to Fas (show FAS Proteins)-mediated apoptosis.

  9. A conserved WW domain-like motif regulates CD74 antigen-dependent cell-surface transport of the NKG2D (show KLRK1 Proteins) ligand ULBP2 (show ULBP2 Proteins).

  10. these results demonstrate that the subunit stoichiometry of oligomeric Ii/MHCII complexes is influenced by p35 (show ANXA1 Proteins).

CD74 Protein Profile

Protein Summary

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with HLA-DR-gamma Proteins (CD74)

  • CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74)
  • CD74 molecule, major histocompatibility complex, class II invariant chain (CD74)
  • Cd74 molecule, major histocompatibility complex, class II invariant chain (Cd74)
  • CLIP protein
  • DHLAG protein
  • HLADG protein
  • Ia-GAMMA protein
  • II protein
  • INVG34 protein

Protein level used designations for HLA-DR-gamma Proteins (CD74)

H-2 class II histocompatibility antigen gamma chain , HLA-DR-GAMMA , Ia-associated invariant chain , MHC class II-associated invariant chain , class II-associated invariant chain peptide , dinucleotide microsatellite , histocompatibility: class II antigens, gamma chain of , ia antigen-associated invariant chain , invariant polypeptide of major histocompatibility complex, class II antigen-associated , CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) , HLA class II histocompatibility antigen gamma chain , HLA-DR antigens-associated invariant chain , HLA-DR-gamma , MHC HLA-DR gamma chain , gamma chain of class II antigens , p33 , ii

GENE ID SPECIES
16149 Mus musculus
972 Homo sapiens
25599 Rattus norvegicus
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