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The protein encoded by HNF1A is a transcription factor required for the expression of several liver-specific genes. Additionally we are shipping HNF1 Homeobox A Kits (30) and HNF1 Homeobox A Proteins (5) and many more products for this protein.
Showing 10 out of 92 products:
Human Monoclonal HNF1A Primary Antibody for IF, WB - ABIN968240
Frain, Swart, Monaci, Nicosia, Stämpfli, Frank, Cortese: The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. in Cell 1989
Show all 5 references for ABIN968240
Human Monoclonal HNF1A Primary Antibody for IHC (fro), WB - ABIN264395
Staal, Burgering, van de Wetering, Clevers: Tcf-1-mediated transcription in T lymphocytes: differential role for glycogen synthase kinase-3 in fibroblasts and T cells. in International immunology 1999
Show all 3 references for ABIN264395
Human Polyclonal HNF1A Primary Antibody for IF, WB - ABIN652663
Bach, Galcheva-Gargova, Mattei, Simon-Chazottes, Guénet, Cereghini, Yaniv: Cloning of human hepatic nuclear factor 1 (HNF1) and chromosomal localization of its gene in man and mouse. in Genomics 1991
Human Polyclonal HNF1A Primary Antibody for ELISA, WB - ABIN334504
Hansen, Párrizas, Jensen, Pruhova, Ek, Boj, Johansen, Maestro, Rivera, Eiberg, Andel, Lebl, Pedersen, Ferrer, Hansen: Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function. in The Journal of clinical investigation 2002
Hepatocellular adenomas, specifically the HNF1-alpha subtype, can cause false-positive PET findings when seeking to identify malignancy.
Plasma ghrelin (show GHRL Antibodies) level is higher in HNF1A-maturity onset diabetes of the young than in the common polygenic forms of diabetes.
rejected the hypothesis that all human MODY (show HNF4A Antibodies)-associated mutations in HNF1A / HNF4A (show HNF4A Antibodies) induce changes in the pharmacokinetics of sulfonylureas in humans analogically to the Hnf1a(-/-) mouse model
TCF-1 expression was lower in T cells from multiple sclerosis patients compared to healthy individuals.
HNF-1alpha gene p379fsinsC mutation is described in a Chinese family with maturity-onset diabetes of the young type 3.
Genetic screening detected a mutation p. Arg200Trp in the HNF1A gene in the patient, her mother, and maternal grandmother, suggesting a diagnosis of MODY-3
DR of any degree was not present in our GCK (show GCK Antibodies)-MODY (show HNF4A Antibodies) group, while in spite of young age almost every fourth subject with HNF1A-MODY (show HNF4A Antibodies) showed signs of this complication.
These data suggest that HNF1 plays an important role in regulating intestinal epithelial cell function, both directly and through interactions with other intestinal transcription factors.
a pathway in which TNFalpha (show TNF Antibodies)-NF-kappaB (show NFKB1 Antibodies) signaling switches off negative regulation by suppressing HNF-1alpha-mediated expression of miR (show MLXIP Antibodies)-194, revealing insight into the mechanisms linking inflammatory pathways, miRNA, and HCC (show FAM126A Antibodies) metastasis.
rs1169288 in HNF1A significantly associates with alpha-1 antitrypsin (show SERPINA1 Antibodies) levels.
Sp5 (show SP5 Antibodies)/8 bind directly to GC boxes in Wnt (show WNT2 Antibodies) target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1/lymphoid enhancer factor (Lef) 1 (show LEF1 Antibodies) to facilitate recruitment of beta-catenin (show CTNNB1 Antibodies) to target gene enhancers.
TCF1 is required for the T follicular helper cell response to viral infection functioning through negative feedback loops with IL-2 (show IL2 Antibodies) and Blimp1 (show PRDM1 Antibodies).
Our data demonstrate that HNF1A is an important cell-intrinsic transcription factor in adult B lymphopoiesis
This paper demonstrates a cell-intrinsic requirement for transcription factors TCF1 and LEF1 (show LEF1 Antibodies) for the development of all subsets of Natural Killer T cells.
Beta-catenin's function in regulating mouse embryonic stem cells is highly context specific and its interaction with TCF1 promotes differentiation.
HNF1alpha, but not HNF1beta (show HNF1B Antibodies), is the primary positive regulator of PCSK9 (show PCSK9 Antibodies) transcription in mouse liver
IP3R (show ITPR1 Antibodies)-mediated Ca2 (show CA2 Antibodies)+ signaling reinforces Tcf-1 activity to both ensure normal development and to prevent thymocyte neoplasia.
critical for suppression of CD8 (show CD8A Antibodies)-positive T-cell function
TCF-1 physically interacted with Runx3 (show RUNX3 Antibodies) to cooperatively silence Cd4 (show CD4 Antibodies).
Deletion of intestinal SIRT1 (show SIRT1 Antibodies) impairs DCoH2 (show PCBD2 Antibodies)-HNF-1alpha-FXR (show NR1H4 Antibodies) signaling and alters systemic bile acid homeostasis.
pigs harboring the dominant-negative mutant human MODY3 gene showed reproducible and distinct glomerular nodules.
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas.
HNF1 homeobox A
, albumin proximal factor
, hepatic nuclear factor 1
, hepatocyte nuclear factor 1-alpha
, interferon production regulator factor
, liver-specific transcription factor LF-B1
, transcription factor 1, hepatic
, hepatic nuclear factor (HNF1)
, transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor
, hepatocyte nuclear factor 1
, transcription factor 1
, LF-B1 hepatic nuclear factor (HNF1): albumin proximal factor also TCF1
, LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1
, Transcription factor 1 hepatic
, Transcription factor 1, hepatic
, hepatic nuclear factor-1-alpha
, hepatocyte nuclear factor 1 alpha