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anti-HUS1 Checkpoint Homolog (S. Pombe) (HUS1) Antibodies

The protein encoded by HUS1 is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. Additionally we are shipping HUS1 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HUS1 498411  
HUS1 3364 O60921
HUS1 15574 Q8BQY8
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Top anti-HUS1 Antibodies at antibodies-online.com

Showing 10 out of 58 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB HUS1 Antibody (C-term)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the HUS1 antibody detected the HUS1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated IHC (p), WB   100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image HUS1 antibody detects HUS1 protein by Western blot analysis. A. 30 µg C8D30 whole cell lysate/extract 12 % SDS-PAGE HUS1 antibody , dilution: 1:1000 IHC-P Image HUS1 antibody detects HUS1 protein at cytosol and nucleus on rat fore brain by immunohistochemical analysis. Sample: Paraffin-embedded rat fore brain. HUS1 antibody , dilution: 1:500. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation of HUS1 transfected lysate using anti-HUS1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with HUS1 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of HUS1 expression in transfected 293T cell line by HUS1 MaxPab polyclonal antibody.Lane 1: HUS1 transfected lysate(31.70 KDa).Lane 2: Non-transfected lysate. 100 μL Log in to see 9 Days
$418.57
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated IHC (fp), WB 100 μL Log in to see 6 to 11 Days
$485.71
Details
Human Rabbit Un-conjugated IF   50 μL Log in to see 8 to 10 Days
$390.50
Details
Human Mouse Un-conjugated IP, ELISA Detection limit for recombinant GST tagged HUS1 is 0.1 ng/ml as a capture antibody. Immunoprecipitation of HUS1 transfected lysate using anti-HUS1 monoclonal antibody and Protein A Magnetic Bead , and immunoblotted with HUS1 MaxPab rabbit polyclonal antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB   200 μL Log in to see 9 Days
$487.50
Details

HUS1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human , ,
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Mouse (Murine)


More Antibodies against HUS1 Interaction Partners

Human HUS1 Checkpoint Homolog (S. Pombe) (HUS1) interaction partners

  1. These results suggest that p21(Waf1/CIP1 (show CDKN1A Antibodies)) and Hus1 play crucial roles in the generation and transmission of bystander damage signals after low-dose alpha-particle irradiation.

  2. adenine glycosylase activity, mismatch recognition properties and interaction with protein partners of MUTYH (show MUTYH Antibodies) and 5 MAP variants were examined; P502L and R520Q had reduced affinity for PCNA (show PCNA Antibodies); only Q324H was found to have reduced affinity for Hus1

  3. Intramolecular binding of the rad9 (show RAD9A Antibodies) C-terminus in the checkpoint clamp (show PDZK1 Antibodies) Rad9 (show RAD9A Antibodies)-Hus1-Rad1 (show ERCC4 Antibodies) is closely linked with its DNA binding.

  4. these pockets were not required for 9-1-1 chromatin localization or ATR (show ANTXR1 Antibodies)-mediated CHK1 (show CHEK1 Antibodies) activation but were necessary for interactions between HUS1 and its binding partner MYH (show MUTYH Antibodies)

  5. Expression of cell cycle regulatory factors hus1, gadd45a (show GADD45A Antibodies), rb1 (show RB1 Antibodies), cdkn2a (show CDKN2A Antibodies) and mre11a (show MRE11A Antibodies) correlates with expression of clock gene per2 (show PER2 Antibodies) in human colorectal carcinoma tissue.

  6. HUS1 polymorphisms act as risk breast cancer modifiers in the group of non-carriers of BRCA1/2 mutations.

  7. Data show models for the ternary PCNA (show PCNA Antibodies)/FEN1 (show FEN1 Antibodies)/DNA and Rad9 (show RAD9A Antibodies)-Rad1 (show ERCC4 Antibodies)-Hus1 (9-1-1 complex)/FEN1 (show FEN1 Antibodies)/DNA assemblies.

  8. The HUS1 is loaded to damaged sites where it serves as a platform for the selective recruitment of checkpoint and repair proteins.

  9. The HUS1 protein interacts with casein kinase 2.

  10. Rad9 (show RAD9A Antibodies)-Rad1 (show ERCC4 Antibodies)-Hus1 complex enhances in vitro activity of 8-oxoguanine DNA glycosylase (show OGG1 Antibodies).

Mouse (Murine) HUS1 Checkpoint Homolog (S. Pombe) (HUS1) interaction partners

  1. Whereas Hus1(neo/neo) and Atm(-/-) single mutant mice survived low-dose MMC similar to wild-type controls, Hus1(neo/neo)Atm(-/-) double mutants showed striking MMC hypersensitivity.

  2. Disease severity in a mouse model of ataxia (show USP14 Antibodies) telangiectasia is modulated by the DNA damage checkpoint gene Hus1

  3. HUS1 acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 (show RAD1 Antibodies) and TOPBP1 (show TOPBP1 Antibodies) respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 (show RAD9A Antibodies) or HUS1.

  4. requirement for Hus1 in the survival and proliferation of mammary epithelium

  5. Hus1 is required specifically for one of two separable mammalian checkpoint pathways that respond to distinct forms of genome damage during S phase.

  6. Hus1-deficient mouse cells had an impaired S checkpoint after exposure to DNA strand break-inducing agents such as camptothecin or ionizing radiation

  7. we show a requirement for Rad17 and Hus1 to induce G(2) arrest as well as Vpr-induced phosphorylation of histone 2A variant X (H2AX) and formation of nuclear foci containing H2AX and breast cancer susceptibility protein 1

  8. results indicate that the role of Hus1 affecting the sensitivity of cells to IR-induced killing is independent of nonhomologous end-joining but might be linked to homologous recombination repair

  9. Hus1 loss leads to chromosomal instability during DNA replication, triggering increased apoptosis and impaired proliferation through p53 (show TP53 Antibodies)-independent mechanisms.

  10. identify differential effects of altered Hus1 gene dosage on genome maintenance during in vitro culture, genotoxic stress responses, embryonic development, and adult homeostasis

HUS1 Antigen Profile

Protein Summary

The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with HUS1

  • HUS1 checkpoint homolog (S. pombe) (Hus1) antibody
  • HUS1 checkpoint homolog (S. pombe) (HUS1) antibody
  • Hus1 homolog (S. pombe) (Hus1) antibody
  • hHUS1 antibody
  • mHus1 antibody

Protein level used designations for HUS1

Hus1 homolog , checkpoint protein HUS1 , hus1+-like protein

GENE ID SPECIES
498411 Rattus norvegicus
3364 Homo sapiens
15574 Mus musculus
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