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Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 Proteins (HEY1)

HEY1 encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Additionally we are shipping HEY1 Antibodies (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HEY1 23462 Q9Y5J3
HEY1 15213  
Rat HEY1 HEY1 155437  
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Top HEY1 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,777.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,808.67
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,808.67
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,849.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

HEY1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1) Interaction Partners

Human Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1) interaction partners

  1. Expression of Hey1 induces translocation of FBXO45 (show FBXO45 Proteins) into the nucleus.

  2. Overexpression of HEY1 and HEY2 (show HEY2 Proteins) in esophageal squamous cell carcinoma (ESCC) is correlated to different indices of poor prognosis, and it is extrapolated that such overexpression is important in progression and development of ESCC tumorigenesis.

  3. bone morphogenic proteins within the serum of cell culture medium are potent inducers of endothelial Hey1 and Hey2 (show HEY2 Proteins) gene expression within the first few hours after medium change

  4. PML degradation mechanism through Notch/Hey1-induced repression of the PML deubiquitinase USP11 involved in brain tumour pathogenesis

  5. MMP9 (show MMP9 Proteins) was a downstream effector of HEY1 that promotes the invasion of osteosarcoma cells. Knockdown of HEY1 decreased the expression of MMP9 (show MMP9 Proteins).

  6. In prostate tumors, the overexpression of PTOV1 was associated with decreased expression of HEY1 and HES1, and this correlation was significant in metastatic lesions.

  7. a new HRD1 (show SYVN1 Proteins)-associated membrane protein named HERP2, which is homologous to the previously identified HRD1 (show SYVN1 Proteins) partner HERP1 (show HEY2 Proteins). Despite sequence homology, HERP2 is constitutively expressed in cells, whereas HERP1 (show HEY2 Proteins) is highly induced by ER stress.

  8. The identification of HEY1-NCOA2 (show NCOA2 Proteins) can be used as an auxiliary diagnostic tool to differentiate meningeal hemangiopericytoma from mesenchymal chondrosarcoma.

  9. HEY1 was overexpressed in colorectal cancer, and correlated with perineural and vascular invasion and lymph node metastasis as well as poorer prognosis.

  10. Data show that the periodontal ligament-derived mesenchymal stem cells (hPDLSCs) on a Jagged-1 (show JAG1 Proteins)-modified surface had increased expression of Notch (show NOTCH1 Proteins) signaling target genes, Hes-1 and Hey-1, suggesting the involvement of Notch (show NOTCH1 Proteins) signaling in hPDLSCs.

Mouse (Murine) Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1) interaction partners

  1. Cyclic stretch enhanced the BMP-2induced osteoblastic differentiation through the inhibition of Hey1.

  2. Hes (show ATCAY Proteins)/Hey signaling at the Atoh1 (show ATOH1 Proteins) promoter has a role in selection of cell fate in the organ of Corti

  3. These in vitro and in vivo data support an anti-adipogenic role of COUP-TFII (show NR2F2 Proteins) via downregulating the Notch (show NOTCH1 Proteins) signaling target gene Hey1.

  4. Hey proteins mechanistically repress target genes via histone deacetylase (show HDAC1 Proteins) recruitment and histone deacetylation.

  5. Hey1 and Hey2 (show HEY2 Proteins) in endothelial cells play important roles in vascular development.

  6. findings indicate that Hey1 and Hey2 (show HEY2 Proteins) control the spatial and temporal pattern of auditory HC differentiation.

  7. This study demonistrated that demonstrates that the lack of Hesr1 leads to an alteration in sensitivity to dopamine accompanied by enhanced prepulse inhibition.

  8. A muscle-specific (show EIF3K Proteins) regulatory element of p57(kip2 (show CDKN1C Proteins)) directly activated by muscle regulatory factors in myoblasts but repressed by the Notch (show NOTCH1 Proteins) targets Hes1/Hey1 in progenitor cells, is identified.

  9. Notch (show NOTCH1 Proteins)-RBPjk (show RBPJ Proteins) signaling functions in part through Hey1-mediated inhibition of NFATc1 (show NFATC1 Proteins) to suppress osteoblastogenesis, contributing to bone homeostasis in vivo

  10. These results indicate that Hesr1 and Hesr3 (show HEYL Proteins) are essential for the generation of adult satellite cells and for the maintenance of skeletal muscle homeostasis.

Zebrafish Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1) interaction partners

  1. Expression of seven hairy/E(spl (show SGPL1 Proteins)) (her) genes is reported in three neurogenic areas of the adult zebrafish brain (telencephalon, hypothalamus, and midbrain) in relation to radial glia, proliferation, and neurogenesis.

  2. hey1 represents a target of Delta-Notch (show NOTCH1 Proteins) signaling dynamically expressed during somite formation in zebrafish

Xenopus laevis Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1) interaction partners

  1. Results suggest that the negative regulatory loops between BMP/Tbx2 (show TBX2 Proteins) and Gremlin (show GREM1 Proteins) or Hey1 are responsible for defining the territory of the pronephric nephron.

  2. HRT1 encodes a bhlh domain motif, a transcription repressor, which acts as an extended dimerization domain that contributes to the selection of partners.

  3. XHRT1 plays an important role in glomerular development and early proximodistal patterning. [Xenopus HRT1]

HEY1 Protein Profile

Protein Summary

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with HEY1

  • hairy/enhancer-of-split related with YRPW motif 1 (HEY1)
  • hairy/enhancer-of-split related with YRPW motif 1 (Hey1)
  • hairy/enhancer-of-split related with YRPW motif 1 (hey1)
  • AI316788 protein
  • AI414254 protein
  • bc8 protein
  • bHLHb31 protein
  • chf2 protein
  • herp2 protein
  • hesr-1 protein
  • hesr1 protein
  • HRT-1 protein
  • hrt1 protein
  • id:ibd1292 protein
  • oaf1 protein
  • xbc8 protein
  • zgc:110572 protein

Protein level used designations for HEY1

HES-related repressor protein 1 , HES-related repressor protein 2 , basic helix-loop-helix protein OAF1 , cardiovascular helix-loop-helix factor 2 , class B basic helix-loop-helix protein 31 , hHRT1 , hairy and enhancer of split-related protein 1 , hairy-related transcription factor 1 , hairy/enhancer-of-split related with YRPW motif protein 1 , HESR-1 , bHLH protein Hesr-1/Hey1 , cardiovascular basic helix-loop-helix factor 2 , HRT-1 , Hairy/E(spl)-related with YRPW motif 1 , mHRT1 , IBD1292 , basic helix-loop-helix transcription factor , XHRT1 , XHey-1 , hesr-1 , protein xbc8 , xHRT-1

GENE ID SPECIES
23462 Homo sapiens
403420 Canis lupus familiaris
408005 Bos taurus
15213 Mus musculus
155437 Rattus norvegicus
58008 Danio rerio
399195 Xenopus laevis
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