Hairless Proteins (HR)

May act as a transcription factor that could act on to regulate one of the phases of hair growth.. Additionally we are shipping Hairless Antibodies (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HR 55806 O43593
Rat HR HR 60563 P97609
HR 15460 Q61645
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Top Hairless Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

HR Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Hairless (HR) Interaction Partners

Human Hairless (HR) interaction partners

  1. We have identified two recurrent missense mutations in U2HR c.1A>T (p. Met1?) and c.104A>G (p.*35Wext1263*) in two Chinese Han families with Marie Unna Hereditary Hypotrichosis.

  2. study reports two cases of Marie Unna hereditary hypotrichosis; a novel nonsense mutation of U2HR was identified in the second case, but no causative mutation in U2HR or EPS8L3 (show EPS8L3 Proteins) was found in the first case

  3. we have identified a mutation, c.74C>T, in a Chinese family with MUHH, which has been previously described in a family from Hungary. Our findings therefore indicate the prevalence of this mutation in diverse populations.

  4. Findings indicate that hairless (HR) is a H3K9 demethylase (show MBD2 Proteins) that regulates epidermal homeostasis via direct control of its target genes.

  5. Unliganded VDR (show CYP27B1 Proteins) upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1 (show SOSTDC1 Proteins).

  6. deletion mutants of hairless indicate that the JmjC domain contributes to the co-repressor activity

  7. Mutations in the gene HR coding for the hairless protein are associated with an autosomal recessive form of alopecia universalis

  8. Marie Unna hereditary hypotrichosis is caused by a novel mutation (U2HR) in the human hairless transcript.

  9. study reports a family with Marie Unna hereditary hypotrichosis (MUHH) from Turkey; identified the mutation c.2T > C (M1T) in all affected family members; concluded that there may be considerable clinical variations in MUHH

  10. Hr and VDR (show CYP27B1 Proteins) interact via multiple protein-protein interfaces, catalyzing histone demethylation to effect chromatin remodeling and repress the transcription of VDR (show CYP27B1 Proteins) target genes that control the hair cycle.

Mouse (Murine) Hairless (HR) interaction partners

  1. This study examinedthe uncommon phenotype and using microarray analyses and functional studies, we found that beta-catenin was mediated by Hr. Progenitor keratinocytes from the bulge region differentiate into both epidermis and sebaceous glands, and fail to adopt the hair keratinocytes fate in the mutant scalp, due to the decreased Wnt/beta-catenin signaling in the absence of the hairless protein.

  2. HR regulates expression of genes in the MSX2 regulatory pathway, which explains abnormal hair follicle formation in Hr(Hp)/Hr(Hp) skin.

  3. Hairless is required for adipocyte differentiation.

  4. Hr loss results in a state of uncontrolled epidermal proliferation that promotes tumor development, and Hr mutant mice should no longer be considered merely hairless 'wild-type' mice

  5. regulation of Dlx3 (show DLX3 Proteins) by HR affects the IRS (show IARS Proteins) keratin expression, thus modulating the formation of IRS (show IARS Proteins) of hair follicle.

  6. Foxe1 (show FOXE1 Proteins) mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes.

  7. Hr evokes an anti-apoptotic response by disrupting a p53 (show TP53 Proteins) dependent pathway involving Bcl2 (show BCL2 Proteins) family members.

  8. hairless phenotype in CR rats is not allelic with mouse hairless

  9. This thyroid hormone (show PTH Proteins)-regulated corepressor associates with histone deacetylases in neonatal rat brain.

  10. HR regulates the precise timing of Wnt (show WNT2 Proteins) signaling required for hair follicle regeneration.

Hairless (HR) Protein Profile

Protein Summary

This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by multiple regulatory ORFs that exist upstream of the primary ORF. Mutations in one of these upstream ORFs, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Hairless Proteins (HR)

  • hair growth associated (HR)
  • hairless homolog (mouse) (HR)
  • hair growth associated (Hr)
  • hairless (Hr)
  • ALUNC protein
  • AU protein
  • ba protein
  • bldy protein
  • hr protein
  • HSA277165 protein
  • MUHH protein
  • MUHH1 protein
  • N protein
  • rh protein
  • rh-bmh protein
  • rhino protein

Protein level used designations for Hairless Proteins (HR)

hairless homolog , protein hairless , hairless homolog (mouse) , hairless protein , protein hairless-like

GENE ID SPECIES
55806 Homo sapiens
100053727 Equus caballus
486130 Canis lupus familiaris
785815 Bos taurus
464040 Pan troglodytes
60563 Rattus norvegicus
397617 Sus scrofa
443241 Ovis aries
574164 Macaca mulatta
100033094 Monodelphis domestica
100357019 Oryctolagus cuniculus
100451474 Pongo abelii
100478044 Ailuropoda melanoleuca
15460 Mus musculus
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