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Hairy and Enhancer of Split 5 (Drosophila) Proteins (HES5)

HES5 encodes a member of a family of basic helix-loop-helix transcriptional repressors. Additionally we are shipping HES5 Antibodies (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HES5 388585 Q5TA89
HES5 15208 P70120
Rat HES5 HES5 79225 Q03062
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Top HES5 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

HES5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Hairy and Enhancer of Split 5 (Drosophila) (HES5) Interaction Partners

Zebrafish Hairy and Enhancer of Split 5 (Drosophila) (HES5) interaction partners

  1. Over-expression of her12, her15 or her7 disrupts cyclic gene expression and somite border formation, and structure function analysis of Her7 indicates that DNA binding, but not Groucho-recruitment seems to be important in this process.

Human Hairy and Enhancer of Split 5 (Drosophila) (HES5) interaction partners

  1. that suppression of the HES5 leading to inhibition of proliferation may be one of the mechanisms against Hepatocellular carcinoma

  2. HES5 silencing is an early and recurrent change in prostate tumourigenesis

  3. these data identify HES5 as a key mediator of the Wnt-3a (show WNT3A Proteins) proneurogenic effect occurring independently of the classical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling cascade thus further deciphering crosstalk mechanisms of Wnt (show WNT2 Proteins) and Notch (show NOTCH1 Proteins) signaling pathways regulating cell fate

  4. the downstream Notch (show NOTCH1 Proteins) signalling effector HES5 directly represses transcription of the E3 ligase Fbw7beta.

  5. Notch3 (show NOTCH3 Proteins) and Hes5 are hypermethylated in human B cell acute lymphoblastic leukemia (ALL).

  6. Hes5 overactivation is associated with cell differentiation, thereby resulting in uterine carcinogenesis.

  7. In this study, HES 5 transcription factor was detected in the lining epithelium of human periapical cysts with limited inflammation, showing Notch (show NOTCH1 Proteins) pathway activation in those cells.

  8. The expression of HES5 in adenocarcinoma was significantly higher than those in adenoma and normal control

  9. For marking and purifying neural stem cells to ascertain whether differences exist, we generated transgenic mice using promoters from Hes (show RRBP1 Proteins) genes (pHes1 or pHes5) to drive expression of destabilized enhanced green fluorescent protein.

  10. Notch protein binding to Hes5-GFP is extinguished fast and recovered slowly, whereas Hes1-GFP is inhibited late and recovered quickly

Mouse (Murine) Hairy and Enhancer of Split 5 (Drosophila) (HES5) interaction partners

  1. This study demonstrated that Hes1 and Hes5 modulate not only maintenance of progenitor cells but also pituicyte versus neuron fate specification during neurohypophysis development.

  2. delivery of siRNA to Hes1 and Hes5 using a transfection reagent or siRNA to Hes1 encapsulated within nanoparticles increased hair cell numbers in non-toxin treated organotypic cultures of cochleae and maculae

  3. The transcription and expression patterns of Notch (show NOTCH1 Proteins) pathway components (Notch 1 (show NOTCH1 Proteins)-3, Delta1 and 4, Jagged1 (show JAG1 Proteins)) and effectors (Hes1, Hes2 (show HES2 Proteins), Hes5 and Nrarp (show NRARP Proteins)) were evaluated in the mouse testis

  4. Hes1 and Hes5 regulate vascular remodeling and arterial fate specification of endothelial cells in the development of the brain; they are critical transducers of Notch (show NOTCH1 Proteins) signals in brain vascular development.

  5. the downstream Notch (show NOTCH1 Proteins) signalling effector HES5 directly represses transcription of the E3 ligase Fbw7beta.

  6. Data demonstrate that Hes5 levels in the utricle decreased after the application of siRNA and that the number of hair cells in these utricles was significantly larger than following control treatment.

  7. Epigenetic silencing of Hes5 leads to neuronal differentiation despite active Notch (show NOTCH1 Proteins) signaling.

  8. Simultaneous overexpression of Hes5 and Sox21 (show SOX21 Proteins) reveals Hes5 as a downstream effector of Sox21 (show SOX21 Proteins) in adult hippocampus neurogenesis.

  9. This study suggested that Hes5 expression is serially activated first by Gcms and later by the canonical Notch (show NOTCH1 Proteins) pathway

  10. Hes1, Hes5 and Hey1 (show HEY1 Proteins) cooperatively inhibit hair cell formation, and one allele of Hes1, Hes5 or Hey1 (show HEY1 Proteins) is sufficient for supporting cell (show PTPRJ Proteins) production probably by lateral inhibition in the sensory epithelium.

HES5 Protein Profile

Protein Summary

This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer.

Gene names and symbols associated with HES5

  • hairy and enhancer of split-related 15.1 (her15.1)
  • hairy and enhancer of split 5 (Drosophila) (HES5)
  • hairy and enhancer of split 5 (Drosophila) (hes5)
  • hairy and enhancer of split 5 (LOC100221262)
  • hairy and enhancer of split 5 (LOC100226434)
  • hairy and enhancer of split 5 (Drosophila) (Hes5)
  • bHLHb38 protein
  • fk51a02 protein
  • her15 protein
  • hes5 protein
  • wu:fk51a02 protein
  • zgc:136520 protein

Protein level used designations for HES5

hairy and enhancer of split 5 , her15a , transcription factor HES-5 , Transcription factor HES-5 , class B basic helix-loop-helix protein 38

GENE ID SPECIES
359836 Danio rerio
419392 Gallus gallus
787633 Bos taurus
100195635 Salmo salar
100221262 Taeniopygia guttata
100226434 Taeniopygia guttata
388585 Homo sapiens
15208 Mus musculus
79225 Rattus norvegicus
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