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HES6 encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Additionally we are shipping Hairy and Enhancer of Split 6 (Drosophila) Antibodies (59) and Hairy and Enhancer of Split 6 (Drosophila) Proteins (4) and many more products for this protein.
the PT enhancer with the 3'UTR (show UTS2R ELISA Kits) of hes6 responded to the inhibition of retinoic acid synthesis and fibroblast growth factor signaling in a manner similar to endogenous hes6.
hes6, the clock gene that does not oscillate, responds to negative feedback
Data define a network of Her/Hes (show ATCAY ELISA Kits) dimers underlying transcriptional negative feedback within the zebrafish segmentation clock, where Her7 acts directly within the delayed negative feedback as a DNA-binding heterodimer with Hes6.
Forms specific heterodimers with her1 (show EGFR ELISA Kits), which may directly be required for regulating further target genes.
Hes6 is involved in the regulation of neuroblast differentiation during adult neurogenesis, but does not influence integration into mature neurons.
Hes6 physically and functionally interacts with RelA (show NFkBP65 ELISA Kits)-containing NF-kappaB (show NFKB1 ELISA Kits) complexes in cortical progenitor cells to control cortical neurogenesis.
Hes6 regulates myogenic differentiation.
Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity.
Hes6 is a regulator of the neurogenic phase of cortical development by promoting neuronal fate while suppressing astrocyte differentiation.
ATOH1 (show ATOH1 ELISA Kits) activates HES6 transcription through binding to three clustered E boxes of its promoter
Data reveal a role for Ascl1 (show ASCL1 ELISA Kits) in the regulation of Hes6, a proneurogenic factor that inhibits Notch (show NOTCH1 ELISA Kits) signaling to promote neural rather than glial differentiation
prostate cancer-specific up-regulation of NOTCH3 (show NOTCH3 ELISA Kits) and HES6, is reported.
HES6 mutations are associated with castration resistant and androgen independent tumors in prostate cancer.
HES6 is up-regulated in aggressive human prostate cancer and drives tumour growth by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1 (show E2F1 ELISA Kits).
HES6 contributes to the pathogenesis of alveolar rhabdomyosarcoma by enhancing both proliferation and cell motility.
HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation.
Data suggest that Hes-6 is a potential oncogene (show RAB1A ELISA Kits) overexpressed in breast cancer, with a tumor-promoting and proliferative function. Hes-6 is a novel estrogen-regulated gene in breast cancer cells.
Here, we show that WRPW motif deletion mutant Hes6 protein is substantially stabilized in comparison to the full length protein and that the enhanced stability is due to its resistance to proteasomal degradation.
Hes6 overexpression using a retroviral vector led to a decrease in Hes1 levels, an increase in beta-cell transcription factors and partial restoration of insulin (show INS ELISA Kits) expression
Increased expression of Notch3 (show NOTCH3 ELISA Kits), Jagged1 (show JAG1 ELISA Kits), Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells.
This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.
hairy and enhancer of split 6
, transcription cofactor HES-6
, class B basic helix-loop-helix protein 41