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Hairy and Enhancer of Split 6 (Drosophila) Proteins (HES6)

HES6 encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Additionally we are shipping Hairy and Enhancer of Split 6 (Drosophila) Antibodies (58) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HES6 55927 Q9JHE6
HES6 55502 Q96HZ4
Rat HES6 HES6 316626  
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Top Hairy and Enhancer of Split 6 (Drosophila) Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
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HES6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Hairy and Enhancer of Split 6 (Drosophila) (HES6) Interaction Partners

Zebrafish Hairy and Enhancer of Split 6 (Drosophila) (HES6) interaction partners

  1. the PT enhancer with the 3'UTR of hes6 responded to the inhibition of retinoic acid synthesis and fibroblast growth factor signaling in a manner similar to endogenous hes6.

  2. hes6, the clock gene that does not oscillate, responds to negative feedback

  3. Data define a network of Her/Hes (show ATCAY Proteins) dimers underlying transcriptional negative feedback within the zebrafish segmentation clock, where Her7 acts directly within the delayed negative feedback as a DNA-binding heterodimer with Hes6.

  4. Forms specific heterodimers with her1 (show EGFR Proteins), which may directly be required for regulating further target genes.

Mouse (Murine) Hairy and Enhancer of Split 6 (Drosophila) (HES6) interaction partners

  1. Hes6 is involved in the regulation of neuroblast differentiation during adult neurogenesis, but does not influence integration into mature neurons.

  2. Hes6 physically and functionally interacts with RelA (show NFkBP65 Proteins)-containing NF-kappaB (show NFKB1 Proteins) complexes in cortical progenitor cells to control cortical neurogenesis.

  3. Hes6 regulates myogenic differentiation.

  4. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity.

  5. Hes6 is a regulator of the neurogenic phase of cortical development by promoting neuronal fate while suppressing astrocyte differentiation.

  6. ATOH1 (show ATOH1 Proteins) activates HES6 transcription through binding to three clustered E boxes of its promoter

  7. Data reveal a role for Ascl1 (show ASCL1 Proteins) in the regulation of Hes6, a proneurogenic factor that inhibits Notch (show NOTCH1 Proteins) signaling to promote neural rather than glial differentiation

Human Hairy and Enhancer of Split 6 (Drosophila) (HES6) interaction partners

  1. prostate cancer-specific up-regulation of NOTCH3 (show NOTCH3 Proteins) and HES6, is reported.

  2. HES6 mutations are associated with castration resistant and androgen independent tumors in prostate cancer.

  3. HES6 is up-regulated in aggressive human prostate cancer and drives tumour growth by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1 (show E2F1 Proteins).

  4. HES6 contributes to the pathogenesis of alveolar rhabdomyosarcoma by enhancing both proliferation and cell motility.

  5. HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation.

  6. Data suggest that Hes-6 is a potential oncogene (show RAB1A Proteins) overexpressed in breast cancer, with a tumor-promoting and proliferative function. Hes-6 is a novel estrogen-regulated gene in breast cancer cells.

  7. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity.

  8. Here, we show that WRPW motif deletion mutant Hes6 protein is substantially stabilized in comparison to the full length protein and that the enhanced stability is due to its resistance to proteasomal degradation.

  9. Hes6 overexpression using a retroviral vector led to a decrease in Hes1 levels, an increase in beta-cell transcription factors and partial restoration of insulin (show INS Proteins) expression

  10. Increased expression of Notch3 (show NOTCH3 Proteins), Jagged1 (show JAG1 Proteins), Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells.

Hairy and Enhancer of Split 6 (Drosophila) (HES6) Protein Profile

Protein Summary

This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with HES6

  • hairy and enhancer of split 6 (Drosophila) (hes6)
  • hairy and enhancer of split 6 (Hes6)
  • hairy and enhancer of split 6 (Drosophila) (HES6)
  • hairy and enhancer of split 6 (Drosophila) (Hes6)
  • AI326893 protein
  • bHLHb41 protein
  • bHLHc23 protein
  • her13.2 protein
  • HES-6 protein
  • YF-30 protein

Protein level used designations for HES6

hairy and enhancer of split 6 , transcription cofactor HES-6 , C-HAIRY1 , class B basic helix-loop-helix protein 41

GENE ID SPECIES
373116 Danio rerio
55927 Mus musculus
55502 Homo sapiens
316626 Rattus norvegicus
531384 Bos taurus
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