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HES7 encodes a member of the hairy and enhancer of split family of bHLH transcription factors. Additionally we are shipping HES7 Antibodies (49) and HES7 Proteins (4) and many more products for this protein.
an Indian family links Coats plus syndrome and dextrocardia with a homozygous novel CTC1 (show CTC1 ELISA Kits) and a rare HES7 variation
mutation of HES7 is uniquely associated with defects in vertebral, heart and neural tube formation, and this observation will help provide a discriminatory diagnostic guide in patients with SCD (show SCD ELISA Kits), as well as inform molecular genetic testing.
MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.
Two new missense mutations in HES7 in a family with spondylocostal dysostosis.
R25W missense mutation of HES7 is causative of Spondylocostal dysostosis.
Lengthening the third Hes7 intron by 10 or 20 kb disrupts accurate RNA splicing and inactivates the gene.
Fgf signaling was found to be a primary target for hypoxia, which causes phenotypic variations of heterozygous mutations in Hes7 or Mesp2 (show Mesp2 ELISA Kits), suggesting gene-environment interaction through this signaling.
Hes7 is a key regulator of the pace of the segmentation clock.
Tbx6 (show TBX6 ELISA Kits) and the Wnt (show WNT2 ELISA Kits) pathway cooperatively regulate proper Hes7 expression.
introns lead to an approximately 19-min delay in the Hes7 gene expression, and mathematical modeling suggested that without such a delay, Hes7 oscillations would be abolished
there are differential axial requirements for lunatic fringe (show LFNG ELISA Kits) and Hes7 transcription during mouse somitogenesis
periodic repression by Hes7 protein is critical for the cyclic transcription of Hes7 and Lfng (show LFNG ELISA Kits), and this negative feedback represents a molecular basis for the segmentation clock
instability of Hes7 is essential for sustained oscillation and for its function as a segmentation clock
Lunatic fringe (show LFNG ELISA Kits) and Hes7 controls their oscillatory expression during somitogenesis by forming negative feedback loop
Hes7 oscillation is initiated by Fgf signaling and propagated/maintained anteriorly by Notch (show NOTCH1 ELISA Kits) signaling.
This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.
bHLH factor Hes7
, class B basic helix-loop-helix protein 37
, transcription factor HES-7