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anti-Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2) Antibodies

HEY2 encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. Additionally we are shipping HEY2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HEY2 23493 Q9UBP5
HEY2 15214 Q9QUS4
HEY2 155430  
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Top anti-HEY2 Antibodies at antibodies-online.com

Showing 10 out of 70 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-HEY2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: NCI-H226 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB HEY2 Antibody (N-term) (ABIN652095) western blot analysis in mouse heart tissue lysates (15 µg/lane). This demonstrates the HEY2 antibody detected HEY2 protein (arrow). HEY2 antibody (N-term) (ABIN652095) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Zebrafish Rabbit Un-conjugated WB DANRE hey2 Antibody (C-term) (ABIN1881411) western blot analysis in zebra fish brain tissue lysates (35 µg/lane). This demonstrates the DANRE hey2 antibody detected the DANRE hey2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from K562 cells, using HEY2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit PE IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated ELISA, WB HEY2 monoclonal antibody (M02), clone 2B10. Western Blot analysis of HEY2 expression in human pancreas. Detection limit for recombinant GST tagged HEY2 is 3 ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details

HEY2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-HEY2 Antibodies

  1. Zebrafish (Danio rerio) Polyclonal HEY2 Primary Antibody for WB - ABIN1881411 : Winkler, Elmasri, Klamt, Volff, Gessler: Characterization of hey bHLH genes in teleost fish. in Development genes and evolution 2003 (PubMed)
    Show all 3 references for ABIN1881411

  2. Chicken Polyclonal HEY2 Primary Antibody for WB - ABIN2780874 : Tang, Urs, Liaw: Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. in Circulation research 2008 (PubMed)

More Antibodies against HEY2 Interaction Partners

Human Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2) interaction partners

  1. Individuals with HEY2 duplications should be screened for congenital heart defects.

  2. HEY2 CC genotype may be a favorable prognostic marker for BrS, protectively acting to prevent ventricular fibrillation presumably by regulating the repolarization current.

  3. Overexpression of HEY1 (show HEY1 Antibodies) and HEY2 in esophageal squamous cell carcinoma (ESCC) is correlated to different indices of poor prognosis, and it is extrapolated that such overexpression is important in progression and development of ESCC tumorigenesis.

  4. bone morphogenic proteins within the serum of cell culture medium are potent inducers of endothelial Hey1 (show HEY1 Antibodies) and Hey2 gene expression within the first few hours after medium change

  5. a new HRD1 (show SYVN1 Antibodies)-associated membrane protein named HERP2 (show HEY1 Antibodies), which is homologous to the previously identified HRD1 (show SYVN1 Antibodies) partner HERP1. Despite sequence homology, HERP2 (show HEY1 Antibodies) is constitutively expressed in cells, whereas HERP1 is highly induced by ER stress.

  6. Data indicate that culture abrogated differential gene expression in part due to gradual loss of canonical Notch (show NOTCH1 Antibodies) activity and HEY2 expression.

  7. Common variants at SCN5A (show SCN5A Antibodies)-SCN10A (show SCN10A Antibodies) and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

  8. Hey2 and COUP-TFII (show NR2F2 Antibodies) have an important role in arteriovenous differentiation of human endothelial cells.

  9. Report down-regulation of Notch (show NOTCH1 Antibodies) signaling components NOTCH3 (show NOTCH3 Antibodies) and HEY2 in abdominal aortic aneurysms.

  10. Through activating the Dll4 (show DLL4 Antibodies)-Notch (show NOTCH1 Antibodies)-Hey2 signaling pathway, HGF (show HGF Antibodies) indirectly promotes the proliferation and migration ability of cells, so that offspring artery branches are formed.

Mouse (Murine) Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2) interaction partners

  1. Hey proteins mechanistically repress target genes via histone deacetylase (show HDAC1 Antibodies) recruitment and histone deacetylation.

  2. Results suggest that bone morphogenetic protein signaling plays pivotal roles in retinal progenitor cell differentiation into late differentiating retinal cell types and in Muller glia maturation; these effects were mediated, at least in part, by Hey2

  3. Hey1 (show HEY1 Antibodies) and Hey2 in endothelial cells play important roles in vascular development.

  4. findings indicate that Hey1 (show HEY1 Antibodies) and Hey2 control the spatial and temporal pattern of auditory HC differentiation.

  5. CHF1/Hey2 may contribute to Brugada syndrome.

  6. Common variants at SCN5A (show SCN5A Antibodies)-SCN10A (show SCN10A Antibodies) and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.

  7. Data indicate that Hairy and Enhancer of Split-related with YRPW motif (HEY)2 decreases skeletal mass and regulates bone remodeling in male mice.

  8. Data indicate that Notch1 (show NOTCH1 Antibodies) and Notch2 (show NOTCH2 Antibodies) are expressed and localized in the nuclei of the label-retaining cells (LRCs), and the expression of Notch (show NOTCH1 Antibodies)-inducible genes, Hes1 and Hey2, was elevated in LRCs.

  9. Survivor mice lacking the Hesr2 gene exhibit fibrosis in the aortic valve and ventricle in adulthood, thus suggesting that Hesr2 plays an important role in maintaining the homeostasis of the aortic valve and ventricle.

  10. Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6 (show FKBP1B Antibodies).

Zebrafish Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2) interaction partners

  1. essential role for Hey2 upstream of Notch in hematopoietic stem cell formation

  2. Forms a complex with Gata5 through the carboxyl region and can repress Gata5-mediated transcription.

  3. The snrk (show SNRK Antibodies)-1 gene acts downstream or parallel to notch (show NOTCH1 Antibodies) and upstream of gridlock during artery-vein specification

HEY2 Antigen Profile

Protein Summary

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

Gene names and symbols associated with HEY2

  • hairy/enhancer-of-split related with YRPW motif 2 (HEY2) antibody
  • hairy/enhancer-of-split related with YRPW motif 2 (Hey2) antibody
  • hairy/enhancer-of-split related with YRPW motif 2 (hey2) antibody
  • bHLHb32 antibody
  • CHF1 antibody
  • GRIDLOCK antibody
  • grl antibody
  • Herp1 antibody
  • hesr2 antibody
  • Hrt2 antibody
  • zgc:136746 antibody

Protein level used designations for HEY2

hairy/enhancer-of-split related with YRPW motif protein 2 , HES-related repressor protein 1 , HES-related repressor protein 2 , HESR-2 , HRT-2 , cardiovascular basic helix-loop-helix factor 1 , cardiovascular helix-loop-helix factor 1 , class B basic helix-loop-helix protein 32 , hCHF1 , hHRT2 , hairy and enhancer of split-related protein 2 , hairy-related transcription factor 2 , protein gridlock homolog , Hairy-E(spl)-related with YRPW motif 2 , hairy and enhancer of split related 2 , mHRT2 , Herp2 , gridlock , protein gridlock

GENE ID SPECIES
100152404 Sus scrofa
23493 Homo sapiens
15214 Mus musculus
58146 Danio rerio
484115 Canis lupus familiaris
538619 Bos taurus
155430 Rattus norvegicus
421718 Gallus gallus
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