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Hairy/enhancer-of-Split Related with YRPW Motif 2 Proteins (HEY2)

HEY2 encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. Additionally we are shipping HEY2 Antibodies (70) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HEY2 23493 Q9UBP5
HEY2 15214 Q9QUS4
Rat HEY2 HEY2 155430  
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Top HEY2 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,871.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

HEY2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2) Interaction Partners

Human Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2) interaction partners

  1. Individuals with HEY2 duplications should be screened for congenital heart defects.

  2. HEY2 CC genotype may be a favorable prognostic marker for BrS, protectively acting to prevent ventricular fibrillation presumably by regulating the repolarization current.

  3. Overexpression of HEY1 (show HEY1 Proteins) and HEY2 in esophageal squamous cell carcinoma (ESCC) is correlated to different indices of poor prognosis, and it is extrapolated that such overexpression is important in progression and development of ESCC tumorigenesis.

  4. bone morphogenic proteins within the serum of cell culture medium are potent inducers of endothelial Hey1 (show HEY1 Proteins) and Hey2 gene expression within the first few hours after medium change

  5. a new HRD1 (show SYVN1 Proteins)-associated membrane protein named HERP2 (show HEY1 Proteins), which is homologous to the previously identified HRD1 (show SYVN1 Proteins) partner HERP1. Despite sequence homology, HERP2 (show HEY1 Proteins) is constitutively expressed in cells, whereas HERP1 is highly induced by ER stress.

  6. Data indicate that culture abrogated differential gene expression in part due to gradual loss of canonical Notch (show NOTCH1 Proteins) activity and HEY2 expression.

  7. Common variants at SCN5A (show SCN5A Proteins)-SCN10A (show SCN10A Proteins) and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

  8. Hey2 and COUP-TFII (show NR2F2 Proteins) have an important role in arteriovenous differentiation of human endothelial cells.

  9. Report down-regulation of Notch (show NOTCH1 Proteins) signaling components NOTCH3 (show NOTCH3 Proteins) and HEY2 in abdominal aortic aneurysms.

  10. Through activating the Dll4 (show DLL4 Proteins)-Notch (show NOTCH1 Proteins)-Hey2 signaling pathway, HGF (show HGF Proteins) indirectly promotes the proliferation and migration ability of cells, so that offspring artery branches are formed.

Mouse (Murine) Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2) interaction partners

  1. Hey proteins mechanistically repress target genes via histone deacetylase (show HDAC1 Proteins) recruitment and histone deacetylation.

  2. Results suggest that bone morphogenetic protein signaling plays pivotal roles in retinal progenitor cell differentiation into late differentiating retinal cell types and in Muller glia maturation; these effects were mediated, at least in part, by Hey2

  3. Hey1 (show HEY1 Proteins) and Hey2 in endothelial cells play important roles in vascular development.

  4. findings indicate that Hey1 (show HEY1 Proteins) and Hey2 control the spatial and temporal pattern of auditory HC differentiation.

  5. CHF1/Hey2 may contribute to Brugada syndrome.

  6. Common variants at SCN5A (show SCN5A Proteins)-SCN10A (show SCN10A Proteins) and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.

  7. Data indicate that Hairy and Enhancer of Split-related with YRPW motif (HEY)2 decreases skeletal mass and regulates bone remodeling in male mice.

  8. Data indicate that Notch1 (show NOTCH1 Proteins) and Notch2 (show NOTCH2 Proteins) are expressed and localized in the nuclei of the label-retaining cells (LRCs), and the expression of Notch (show NOTCH1 Proteins)-inducible genes, Hes1 and Hey2, was elevated in LRCs.

  9. Survivor mice lacking the Hesr2 gene exhibit fibrosis in the aortic valve and ventricle in adulthood, thus suggesting that Hesr2 plays an important role in maintaining the homeostasis of the aortic valve and ventricle.

  10. Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6 (show FKBP1B Proteins).

Zebrafish Hairy/enhancer-of-Split Related with YRPW Motif 2 (HEY2) interaction partners

  1. essential role for Hey2 upstream of Notch in hematopoietic stem cell formation

  2. Forms a complex with Gata5 through the carboxyl region and can repress Gata5-mediated transcription.

  3. The snrk (show SNRK Proteins)-1 gene acts downstream or parallel to notch (show NOTCH1 Proteins) and upstream of gridlock during artery-vein specification

HEY2 Protein Profile

Protein Summary

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

Gene names and symbols associated with HEY2

  • hairy/enhancer-of-split related with YRPW motif 2 (HEY2)
  • hairy/enhancer-of-split related with YRPW motif 2 (Hey2)
  • hairy/enhancer-of-split related with YRPW motif 2 (hey2)
  • bHLHb32 protein
  • CHF1 protein
  • GRIDLOCK protein
  • grl protein
  • Herp1 protein
  • hesr2 protein
  • Hrt2 protein
  • zgc:136746 protein

Protein level used designations for HEY2

hairy/enhancer-of-split related with YRPW motif protein 2 , HES-related repressor protein 1 , HES-related repressor protein 2 , HESR-2 , HRT-2 , cardiovascular basic helix-loop-helix factor 1 , cardiovascular helix-loop-helix factor 1 , class B basic helix-loop-helix protein 32 , hCHF1 , hHRT2 , hairy and enhancer of split-related protein 2 , hairy-related transcription factor 2 , protein gridlock homolog , Hairy-E(spl)-related with YRPW motif 2 , hairy and enhancer of split related 2 , mHRT2 , Herp2 , gridlock , protein gridlock

GENE ID SPECIES
100152404 Sus scrofa
23493 Homo sapiens
15214 Mus musculus
58146 Danio rerio
484115 Canis lupus familiaris
538619 Bos taurus
155430 Rattus norvegicus
421718 Gallus gallus
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