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HRK encodes a member of the BCL-2 protein family. Additionally we are shipping HRK Kits (3) and and many more products for this protein.
Showing 10 out of 45 products:
Human Polyclonal HRK Primary Antibody for WB - ABIN2474088
Giroud, Bernard, Guignier, Gras, Bonaiti, Dumas: [Lack of genetic link between the HLA system and idiopathic generalized epilepsy]. in Presse médicale (Paris, France : 1983) 1991
Show all 4 references for ABIN2474088
Human Polyclonal HRK Primary Antibody for ELISA, WB - ABIN1002403
Lockshin, Osborne, Zakeri: Cell death in the third millennium. in Cell death and differentiation 2000
Show all 3 references for ABIN1002403
Human Polyclonal HRK Primary Antibody for WB - ABIN318751
Nakamura, Ishida, Shimada, Nakase, Sakaki, Konishi: Frequent HRK inactivation associated with low apoptotic index in secondary glioblastomas. in Acta neuropathologica 2005
miR (show MLXIP Antibodies)-23a-3p, miR (show MLXIP Antibodies)-23b-3p, and miR (show MLXIP Antibodies)-149-5p, were downregulated by cytokines and selected for further studies. These miRNAs were found to regulate the expression of the proapoptotic Bcl-2 (show BCL2 Antibodies) proteins DP5 and PUMA (show BBC3 Antibodies) and consequent human beta-cell apoptosis.
our findings suggest that induction of the BH3-only (show BBC3 Antibodies) protein Hrk is a critical step in 2-ME activation of the JNK (show MAPK8 Antibodies)-induced apoptotic pathway, targeting mitochondria by liberating proapoptotic protein Bak (show BAK1 Antibodies).
SUZ12 (show SUZ12 Antibodies) promotes the proliferation of human EOC cells by inhibiting apoptosis and HRK is a novel SUZ12 (show SUZ12 Antibodies) target gene whose upregulation contributes to apoptosis induced by SUZ12 (show SUZ12 Antibodies) knockdown.
Diva (show BCL2L10 Antibodies) binds peptides derived from the BH3 domain of several other proapoptotic Bcl-2 (show BCL2 Antibodies) proteins, including mouse Harakiri, Bid (show BID Antibodies), Bak (show BAK1 Antibodies) and Bmf (show BMF Antibodies).
The BH3-only (show BBC3 Antibodies) protein harakiri (HRK) is transactivated by ATF4 (show ATF4 Antibodies) in severe hypoxia through direct binding of ATF4 (show ATF4 Antibodies) to the promoter region.
Data suggest that DP5 and PUMA/BBC3 (p53 up-regulated modulator of apoptosis (show BBC3 Antibodies)/bcl-2-binding component 3 (show BBC3 Antibodies)) contribute to palmitate-induced apoptosis of pancreatic beta-cells via lipotoxic endoplasmic reticulum stress.
These results are used to propose a tentative structural model of how Harakiri works.
analysis of a novel interaction between Bcl-2 (show BCL2 Antibodies) members Diva (show BCL2L10 Antibodies) and Harakiri
Hrk is involved in the induction of apoptosis in RGCs after optic nerve transection.
apoptosis inducers as diverse as oncoprotein inhibitors and cell death receptor activators trigger Hrk expression via blockade of DREAM in leukemia cells
Hrk deficiency does not significantly attenuate the widespread apoptosis seen in the Bcl-x (show BCL2L1 Antibodies) (-/-) embryonic nervous system, indicating that other BH3-only (show BBC3 Antibodies) molecules, alone or in combination, may regulate BAX (show BAX Antibodies) activation in immature neurons.
DP5 plays an important role in neuronal cell death induced by axotomy and NGF (show NGFB Antibodies) deprivation through the regulation of mitochondrial function and caspase-3 (show CASP3 Antibodies) activation
These results demonstrate that HRK contributes to apoptosis signalling elicited by trophic factor withdrawal in certain neuronal populations but is dispensable for apoptosis of haematopoietic cells.
in response to PAHs, Ahr (show AHR Antibodies)-mediated activation of the harakiri, BCL2 interacting protein (contains only BH3 domain), was necessary for execution of cell death.
The effect of antisense oligonucleoties specific to the harakiri mRNA on spontaneous and induced defects of mouse preimplantation embryo development
This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants.
, BH3-interacting domain-containing protein 3
, activator of apoptosis Hrk
, activator of apoptosis harakiri
, death protein 5
, neuronal death protein DP5
, BH3 interacting (with BCL2 family) domain, apoptosis agonist
, BH3 interacting domain 3