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The protein encoded by HAND1 belongs to the basic helix-loop-helix family of transcription factors. Additionally we are shipping HAND1 Proteins (11) and HAND1 Kits (6) and many more products for this protein.
Showing 10 out of 88 products:
Human Polyclonal HAND1 Primary Antibody for WB - ABIN658328
Reamon-Buettner, Ciribilli, Traverso, Kuhls, Inga, Borlak: A functional genetic study identifies HAND1 mutations in septation defects of the human heart. in Human molecular genetics 2009
Show all 4 references for ABIN658328
Human Monoclonal HAND1 Primary Antibody for ELISA, WB - ABIN2869339
Dai, Cserjesi: The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer. in The Journal of biological chemistry 2002
Show all 2 references for ABIN2869339
Human Monoclonal HAND1 Primary Antibody for ELISA, WB - ABIN969184
Lexer, Welch, Durphy, Rieseberg: Natural selection for salt tolerance quantitative trait loci (QTLs) in wild sunflower hybrids: implications for the origin of Helianthus paradoxus, a diploid hybrid species. in Molecular ecology 2003
Show all 2 references for ABIN969184
Human Polyclonal HAND1 Primary Antibody for IHC, ELISA - ABIN1532673
Knöfler, Meinhardt, Vasicek, Husslein, Egarter: Molecular cloning of the human Hand1 gene/cDNA and its tissue-restricted expression in cytotrophoblastic cells and heart. in Gene 1999
Combined expression of NKX2-5 (show NKX2-5 Antibodies), HAND1, and NOTCH1 (show NOTCH1 Antibodies) coordinately contribute to cardiac malformations in Hhypoplastic left heart syndrome.
These data show that miR (show MLXIP Antibodies)-363 negatively regulates the expression of HAND1
Nuclear translocation of Hand-1 acts as a molecular switch to regulate vascular radiosensitivity in medulloblastoma tumors.
DNA methylation (show HELLS Antibodies) status of NKX2-5 (show NKX2-5 Antibodies), GATA4 (show GATA4 Antibodies) and HAND1 in patients with tetralogy of fallot
Increased methylation levels of HAND1 is associated with highly active Helicobacter pylori-related gastritis.
This is the first report of mutations in the HAND1 gene in Chinese patients with VSD and provides new insight into the etiology of VSD
Hand1 is dispensable for normal tyrosine hydroxylase (show TH Antibodies) and dopamine beta-hydroxylase (show DBH Antibodies) expression in sympathetic neurons, even when Hand2 (show HAND2 Antibodies) gene dosage is concurrently reduced by half.
Somatic mutations in NKX2-5 (show NKX2-5 Antibodies), GATA4 (show GATA4 Antibodies), and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart.
Mutations or sequence variations in HAND1 or NKX2-5 (show NKX2-5 Antibodies) genes may play role in etiology or pathogenesis of atrial isomerism.
Our study shows no evidence of somatic NKX2-5 (show NKX2-5 Antibodies), GATA4 (show GATA4 Antibodies) and HAND1 mutations playing a role in the pathogenesis of Tetralogy of Fallot . Findings suggest that the GATA4 (show GATA4 Antibodies) and HAND1 germline mutations are associated with non-syndromic congenital heart disease.
increased vascular endothelial growth factor(170) levels disturb Hand-1 expression in the region required for normal heart morphogenesis
Hand1 is involved in proper osteogenesis of the bone collar via its control of Ihh (show IHH Antibodies). Hand1 overexpression in the osteochondral progenitors caused defective prenatal diaphysis ossification. Hand1 inhibited Runx2 (show RUNX2 Antibodies) transactivation of the Ihh (show IHH Antibodies) proximal promoter.
Re-expression of HAND1 in colon cancer cells induces terminal differentiation.
Hand1 phosphoregulation in the distal arch neural crest has a critical role in craniofacial morphogenesis
Suggest that prenatal alcohol exposure causes the over-expression of DHAND (show HAND2 Antibodies) and EHAND by increasing H3K14ac in the fetal heart.
Hand1 is part of a novel regulatory pathway linking cardiac oxygen levels with oxygen consumption.
that Hand1 homodimer plays a dominant role during development and its expression dosage is critical for survival, whereas Hand1 heterodimers can be either dispensable or play a regulatory role to modulate the activity of Hand1 homodimer in vivo.
Data suggest that stress-induced MAPK8/9 and PRKAA1/2 regulate transcription factors Eomes/HAND1 and ID2, respectively. Together this network mediates induction of CSH1 by stress.
Hand1-mediated activation of Tbeta4 is essential for yolk sac (show ADCY10 Antibodies) vasculogenesis and embryonic survival, and administration of synthetic TB4 partially rescues yolk sac (show ADCY10 Antibodies) capillary plexus formation in Hand1-null embryos.
Data define a critical threshold of Hand1 expression that is necessary for embryonic survival.
Results show that Hand1 regulates development of lateral mesoderm derivatives and its loss in extraembryonic mesoderm is the primary cause of lethality in Hand1-null embryos.
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.
heart- and neural crest derivatives-expressed protein 1
, heart and neural crest derivatives expressed 1
, basic helix-loop-helix transcription factor HAND1
, eHAND basic helix-loop-helix transcription factor
, Heart- and neural crest derivatives-expressed protein 1
, class A basic helix-loop-helix protein 27
, extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1
, heart and neural crest derivatives expressed transcript 1
, heart and neural crest derivatives-expressed protein 1
, helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast