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The protein encoded by HAND2 belongs to the basic helix-loop-helix family of transcription factors. Additionally we are shipping Heart and Neural Crest Derivatives Expressed 2 Proteins (9) and Heart and Neural Crest Derivatives Expressed 2 Kits (6) and many more products for this protein.
Showing 10 out of 96 products:
Human Monoclonal HAND2 Primary Antibody for WB - ABIN394260
Shen, Li, Shen, Wang, Liu, Guo, Song, Li: Transcription factor HAND2 mutations in sporadic Chinese patients with congenital heart disease. in Chinese medical journal 2010
Show all 5 references for ABIN394260
Human Polyclonal HAND2 Primary Antibody for EIA, IHC (p) - ABIN358596
McFadden, Charité, Richardson, Srivastava, Firulli, Olson: A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. in Development (Cambridge, England) 2001
Show all 5 references for ABIN358596
Human Polyclonal HAND2 Primary Antibody for IHC (p), WB - ABIN390065
Russell, Kemp, Wang, Brody, Izumo: Molecular cloning of the human HAND2 gene. in Biochimica et biophysica acta 1999
Human Monoclonal HAND2 Primary Antibody for RNAi, ELISA - ABIN522935
Cho, Okada, Tsuzuki, Nishigaki, Yasuda, Kanzaki: Progestin-induced heart and neural crest derivatives expressed transcript 2 is associated with fibulin-1 expression in human endometrial stromal cells. in Fertility and sterility 2012
this study is the first to report the association of a HAND2 loss-of-function mutation with an increased vulnerability to tetralogy of Fallot in humans, which provides novel insight into the molecular mechanism underpinning congenital heart disease
HAND2-mediated proteolysis negatively regulates the function of estrogen receptor alpha (show ESR1 Antibodies).
suggest that HAND2 plays a key role in the regulation of progestin-induced decidualization of human endometrial stromal cells.
Reduced protein expression of HAND2 in the myenteric plexus of the aganglionic segment would suggest that HAND2 was involved in the pathogenesis of Hirschsprung disease.
Increased HAND2 methylation was a feature of premalignant endometrial lesions and was seen to parallel a decrease in RNA and protein levels.
Overdosage of Hand2 causes limb and heart defects in the human chromosomal disorder partial trisomy distal 4q.
No evidence of linkage between HAND2 and CL/P was obtained. Levelss of exclusion were obtained with different inheritance models. results did not support HAND2 in CL/P
Expression analyses on both Hand2 conditionally null and hypomorphic backgrounds demonstrate that Hand2 is required for reporter activation in a gene dosage-dependent manner during sympathetic neurogenesis.
Data suggest Hand2 plays an important role in decidualization; expression of Hand2 is significantly increased in response to prostaglandin E2.
These data suggest that cytokines can inhibit norepinephrine transporter (show SLC6A2 Antibodies) expression through downregulation of Hand2 or Gata3 (show GATA3 Antibodies) in cultured sympathetic neurons, but axotomy in adult animals selectively suppresses Hand2 expression.
hand2 can drive cardiomyocyte production in multiple contexts and through multiple mechanisms
These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.
Data indicate that mouse and zebrafish hand2 enhancers both drive transgene expression in the pharyngeal arches.
reduction of fn1 (show FN1 Antibodies) function enables rescue of cardiac fusion in hand2 mutants
the expression and function of hand2 and dlx3b/4b/5a genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches
Our study reveals an unexpected role for Hand2, a key regulator of cell specification and differentiation, in modulating ECM (show MMRN1 Antibodies) remodeling during organogenesis
Hand2-endothelin 1 (show EDN1 Antibodies) effector, patterns ventral pharyngeal cartilage
Hand2 is uniquely required for myocardial polarization.
These results demonstrate in vivo an essential and selective function of hand2 for the noradrenergic differentiation of sympathetic neurons, and implicates tfap2a (show TFAP2A Antibodies) and gata2 as downstream effectors.
Han is required in surrounding tissue, and not in a cell-autonomous manner, for thyroid development.
endocardial Hand2 is an integral downstream component of a Notch (show NOTCH1 Antibodies) endocardium-to-myocardium signaling pathway and a direct transcriptional regulator of Neuregulin1.
analysis uncovers the transcriptional circuits that function in establishing distinct mesenchymal compartments downstream of HAND2 and upstream of SHH (show SHH Antibodies) signaling
Suggest that prenatal alcohol exposure causes the over-expression of DHAND and EHAND (show HAND1 Antibodies) by increasing H3K14ac in the fetal heart.
Hand2 loss-of-function dramatically reduces expression of Dopamine Beta Hydroxylase (Dbh (show DBH Antibodies)), a gene encoding a crucial catecholaminergic biosynthetic enzyme
in vivo inhibition of miR (show MLXIP Antibodies)-25 by a specific antagomir evoked spontaneous cardiac dysfunction and sensitized the murine myocardium to heart failure in a Hand2-dependent manner
overdosage of Hand2 is a major cause for the limb and heart defects phenotypes.
Hand2 and NFATC physically interact on the DEGS1 promoter in the hypoxic mouse heart.
Twist1 (show TWIST1 Antibodies), along with Hand2, is essential for the proximodistal patterning and development of the mandible and ossification.
Results suggest that Hand2 is essential for neurogenesis, neurotransmitter specification and neural network patterning in the developing enteric nervous system.
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.
heart and neural crest derivatives expressed 2
, basic helix-loop-helix transcription factor HAND2
, class A basic helix-loop-helix protein 26
, deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2
, heart- and neural crest derivatives-expressed protein 2
, dHand protein
, heart and neural crest derivatives expressed transcript 2
, hands off
, helix-loop-helix transcription factor expressed in embryo and deciduum