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The protein encoded by HSPA12B contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. Additionally we are shipping HSPA12B Antibodies (24) and HSPA12B Kits (6) and many more products for this protein.
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HSPA12B plays a protective role in vascular endothelial barrier dysfunction by preserving the endothelial permeability during sepsis.
The HSPA12B might regulate the expression and activity of SSeCKS to promote astrocyte inflammatory activation and release of inflammatory mediators, such as TNF-alpha (show TNF Proteins) and IL-1beta (show IL1B Proteins) in spinal cord primary astroglial cultures exposed to LPS (show IRF6 Proteins) treatment.
Results indicate that HSPA12B stimulates lung tumor growth via a Cox-2-dependent mechanism. The present study identified HSPA12B as a novel facilitator of lung tumor growth.
HSPA12B attenuates lipopolysaccharide-induced inflammatory responses in human umbilical vein endothelial cells via activation of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signalling pathway.
Plasma extracellular HSPA12B is elevated in both septic mice and patients.
inhibition of eNOS (show NOS3 Proteins) abrogated the protection of HSPA12B against cardiac dysfunction and remodelling after myocardial infarction
Overexpression of HSPA12B protects against cerebral ischemia/reperfusion injury via a PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)-dependent mechanism.
These results demonstrate a pulmonary protective effect of HSPA12B against endotoxin challenge, which indicates management of HSPA12B expression could serve as a potential therapeutic target for ALI during sepsis/septic shock.
Results suggest that miR (show MLXIP Proteins)-134 might influence neuronal cell survival against ischemic injury in primary cultured neuronal cells and mouse brain with ischemic stroke by negatively modulating HSPA12B protein expression in a posttranscriptional manner
Results show that downregulation of miR (show MLXIP Proteins)-134 could induce neuroprotection against ischemic injury by upregulation of HSPA12B protein expression in vivo and in vitro models
HSPA12A and HSPA12B may play roles in genetic susceptibility to atherosclerosis
The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants.
heat shock 70 kDa protein 12B