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Heat Shock 70kDa Protein 8 Proteins (HSPA8)

HSPA8 encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. Additionally we are shipping HSPA8 Antibodies (227) and HSPA8 Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HSPA8 3312 P11142
HSPA8 24468 P63018
HSPA8 15481 P63017
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Top HSPA8 Proteins at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 3 to 4 Days
$335.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$583.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$715.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$528.00
Details
HOST_Escherichia coli (E. coli) Cow His tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Chicken His tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,868.33
Details

HSPA8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus) ,

Mouse (Murine)

Top referenced HSPA8 Proteins

  1. Human HSPA8 Protein expressed in Escherichia coli (E. coli) - ABIN1686679 : DeLuca-Flaherty, McKay, Parham, Hill: Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis. in Cell 1990 (PubMed)
    Show all 10 references for ABIN1686679

  2. Human HSPA8 Protein expressed in Escherichia coli (E. coli) - ABIN668046 : Dworniczak, Mirault: Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein. in Nucleic acids research 1987 (PubMed)
    Show all 2 references for ABIN668046

  3. Human HSPA8 Protein expressed in Wheat germ - ABIN1307208 : Chow, Mok, Xiao, Khalouei, Brown: Heteromeric complexes of heat shock protein 70 (HSP70) family members, including Hsp70B', in differentiated human neuronal cells. in Cell stress & chaperones 2010 (PubMed)

More Proteins for Heat Shock 70kDa Protein 8 (HSPA8) Interaction Partners

Xenopus laevis Heat Shock 70kDa Protein 8 (HSPA8) interaction partners

  1. hsp72 (show HSPA1A Proteins) was more potent than hsc73 in generating protective immune responses against the class Ia-negative 15/0 tumors.

Human Heat Shock 70kDa Protein 8 (HSPA8) interaction partners

  1. HSPA8 maintains pluripotency of human pluripotent stem cells by binding to the master pluripotency regulator OCT4 (show POU5F1 Proteins) and facilitating its DNA-binding activity.

  2. heat shock cognate 70 (HSC70) is an essential component of Aes (show AES Proteins) foci in colorectal cancer cells.

  3. Cx43 (show GJA1 Proteins)-Hsc70 interaction regulates cell cycle G1/S progression through a novel mechanism by which Cx43 (show GJA1 Proteins)-Hsc70 interaction prevents the nuclear accumulation of p27 (show PAK2 Proteins) through controlling the nuclear translocation of cyclin D1 (show CCND1 Proteins)-CDK4 (show CDK4 Proteins)-p27 (show PAK2 Proteins) complex.

  4. serum HSC71 was identified as a novel serum biomarker of renal cell carcinoma (show MOK Proteins), particularly useful in early diagnosis of clear-cell type.

  5. These findings provide further evidence that histatin 3 may be involved in the regulation of cell proliferation, particularly during G1/S transition, via the ubiquitin-proteasome system of p27(Kip1 (show CDKN1B Proteins)) and HSC70.

  6. constitutive heat shock protein HSC70 forms granule-like structures in the cytoplasm of human cells several days after the exposure to heat stress

  7. These results indicate that CHIP decreases the Kv1.5 (show KCNA5 Proteins) protein level and functional channel by facilitating its degradation in concert with chaperone Hsc70

  8. Active Hsc70 requires active tau to regulate microtubule assembly in vivo, suggesting that tau acts in some ways as a co-chaperone for Hsc70 to coordinate microtubule assembly.

  9. detailed and systematic investigation to characterize if there are significant differences in the CHIP in vitro ubiquitination of human Hsp70 (show HSP70 Proteins) and Hsc70.

  10. HSP70 (show HSP70 Proteins) binds CD91 (show LRP1 Proteins) and TLR4 (show TLR4 Proteins) on decidual CD1a (show CD1A Proteins)(+) dendritic cells, causes their maturation, and increases IL-15 (show IL15 Proteins) in the context of Th1 (show TH1L Proteins) cytokine/chemokine (show CCL1 Proteins) domination, which could support immune response harmful for ongoing pregnancy.

Cow (Bovine) Heat Shock 70kDa Protein 8 (HSPA8) interaction partners

  1. Single-particle fluorescence imaging tracks the dynamics of Hsc70 and its clathrin substrate in real time.

  2. The interaction of the molecular chaperone (show HSP90AA1 Proteins) Hsc70 (HSPA8) with recombinant PrP (show PRNP Proteins) was investigated.

  3. Structure of clathrin coat with bound Hsc70 and auxilin (show DNAJC6 Proteins).

  4. specific association between HSP73 and gentamicin may reduce the chaperone activity of HSP73 in vitro and/or in vivo

  5. report role of HSC70 in the regulation of NMT

  6. studied the process of disassembly by using cryo-electron microscopy to identify the initial binding site of Hsc70 on clathrin-C58J baskets at pH 6, under which conditions disassembly does not proceed further. Hsc70 interactions involve two sites

  7. Coats assembled from recombinant clathrin are good substrates for ATP- and auxilin (show DNAJC6 Proteins)-dependent, Hsc70-catalyzed uncoating.

  8. The structure of an Hsp110 (show HSPH1 Proteins):Hsc70 nucleotide exchange complex, is reported.

  9. analysis of the formation of a stable complex between chaperonin-containing TCP-1 (show CCT6A Proteins) (CCT (show TCP1 Proteins)) and Hsc70

  10. Elevated expression of bovine heat shock cognate (hsc)70 protein increases diabetes and inflammation following islet beta cell damage in a transgenic mouse model.

Mouse (Murine) Heat Shock 70kDa Protein 8 (HSPA8) interaction partners

  1. Hspa8 plays a vital role in genetic differences in responses to stress and ethanol and their interactions

  2. PTEN-like domains of GAK and auxilin are not essential for Hsc70-dependent chaperoning and uncoating of clathrin, but depending on the tissue, these domains appear to increase the efficiency of these co-chaperones.

  3. mass spectrometry-based proteomic analysis identified heat shock cognate 70 (HSC70) as a novel binding protein of FSP27 (show CIDEC Proteins)

  4. These findings indicate that wild type ILK and the non-oncogenic ILK(R211A) mutation comprise a cardioprotective module with Hsp/c70.

  5. these data provide evidence for Hsc70 as a novel neuronal interactor of NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins).

  6. In heat stress conditions, Hsp73 is mobilized to prevent apoptosis in the testes and epididymis, and assists Hsp72 (show HSPA1A Proteins) in the repair of stress-altered protein conformations.

  7. 70-kDa heat shock cognate protein hsc70 mediates calmodulin (show Calm2 Proteins)-dependent nuclear import of the sex-determining factor SRY (show SRY Proteins).

  8. Hsc70, Hdj1 and Hdj2 interact with soluble and fibrillar alpha-synuclein

  9. BAG3 (show BAG3 Proteins) and Hsc70 interact with actin capping protein (show TMOD4 Proteins) CapZ (show CAPZA1 Proteins) to maintain myofibrillar integrity under mechanical stress.

  10. In this study, we report an identification of Hsc70 (Heat shock cognate protein 70) as a critical mediator of RGS9-2 expression that is specifically recruited to the intrinsically disordered C-terminal domain of RGS9-2 following dissociation from R7BP.

HSPA8 Protein Profile

Protein Summary

This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with HSPA8

  • heat shock 70kDa protein 8 (hspa8)
  • heat shock 70kDa protein 8 (HSPA8)
  • heat shock 70kDa protein 8 (Hspa8)
  • heat shock protein 8 (Hspa8)
  • heat shock protein 8 (hspa8)
  • 2410008N15Rik protein
  • HSC54 protein
  • Hsc70 protein
  • Hsc71 protein
  • Hsc73 protein
  • HSP71 protein
  • Hsp73 protein
  • Hspa10 protein
  • LAP1 protein
  • NIP71 protein
  • wu:fb01g06 protein
  • wu:fi48b06 protein

Protein level used designations for HSPA8

LPS-associated protein 1 , N-myristoyltransferase inhibitor protein 71 , constitutive heat shock protein 70 , heat shock 70kd protein 10 , heat shock cognate 71 kDa protein , heat shock cognate protein 54 , lipopolysaccharide-associated protein 1 , Hsc70 ATPase , heat shock 70 kDa protein 8 , heat shock 70kd protein 10 (HSC71) , heat shock cognate 71 kD protein , Heat shock cognate protein 70 , heat shock 70kD protein 8 , heat shock protein 8 , heat shock protein A8 , heat shock cognate 70 , heat shock cognate 71 kDa protein-like protein , heat shock protein 70 cognate , heat shock cognate hsc73 , heat shock protein cognate 70 , heat shock 70kDa protein 8 , heat shock cognate 71-kd protein

GENE ID SPECIES
379319 Xenopus laevis
3312 Homo sapiens
281831 Bos taurus
24468 Rattus norvegicus
395853 Gallus gallus
479406 Canis lupus familiaris
100009679 Equus caballus
100172711 Pongo abelii
15481 Mus musculus
573376 Danio rerio
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