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DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.
HSF-1 ablation not only eliminates heat shock response, but it also transcriptionally up-regulates CYP7A1 (show CYP7A1 ELISA Kits) and MDR1/P-gp (show ABCB4 ELISA Kits) axis in WD-diet fed HSF-1(-/-)/LDLr (show LDLR ELISA Kits)(-/-) mice to reduce atherosclerosis.
Role of HSF1 in heart failure.HSF1 up-regulation of AC6 (show ADCY6 ELISA Kits).
Findings suggest that PGC1alpha protects against hyperthermia by cooperating with HSF1 in the induction of a transcriptional program devoted to the cellular protection from thermal insults.
Heat stress-associated increase in skeletal muscle mass may be induced by heat shock transcription factor 1 (HSF1) and/or HSF1-mediated stress response that activates muscle satellite cells and Akt (show AKT1 ELISA Kits)/p70S6K (show RPS6KB1 ELISA Kits) signalling pathway
Defective Hsf1 inhibits the growth of fibrosarcoma derived from simian virus 40/T antigentransformed mouse embryonic fibroblasts.
Suggest that the early activation of Hsf1 dependent cell stress pathway by mono-allelic mutations in APC (show APC ELISA Kits) can affect cell programming in a way that contributes to cancer onset.
The pharmacological activation of HSF1 promotes thermogenic and mitochondrial gene programs in brown and beige (show LYST ELISA Kits) cells and in skeletal muscle, with profound impact on metabolic parameters.
HSF1 is required for myocardial fibrosis in ISO-treated mice, and the underlying molecular mechanism may involve the regulation of HSP47 (show SERPINH1 ELISA Kits).
Authors have concluded that at the physiological temperature HSF1 and HSF2 cooperate in spermatogenic cells. However, temperature elevation causes remodeling of chromatin binding and interactions between HSFs are disrupted.
A novel regulatory mechanism between Hsf1 and Hsf4b in modulating lens epithelial cell homeostasis.
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
, HSTF 1
, heat shock factor protein 1
, heat shock transcription factor 1