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DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.
These findings provide insight into the role of HSF1 in Leydig cell steroidogenesis, suggesting that it maintains cholesterol transport by recovering StAR under chronic heat stress.
In mammalian cell lines, only heat shock-induced but not basal expression of chaperones is dependent on the mammalian Hsf1 homolog.
Upregulating HSF1 relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP (show DDIT3 ELISA Kits) and increasing HSP70 (show HSP70 ELISA Kits) a5 (BiP/GRP78 (show HSPA5 ELISA Kits)). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 being one likely key player in both systems.
HSF1 translationally augments the proteotoxic stress response.
HSF1 as a central regulator of cellular bioenergetics.
have demonstrated that the levels of HSF1 and heat shock proteins are significantly reduced in affected neuronal tissues from a TDP-43 (show TARDBP ELISA Kits) transgenic mouse model of amyotrophic lateral sclerosis and patients with sporadic amyotrophic lateral sclerosis.
HSF-1 ablation not only eliminates heat shock response, but it also transcriptionally up-regulates CYP7A1 (show CYP7A1 ELISA Kits) and MDR1/P-gp (show ABCB4 ELISA Kits) axis in WD-diet fed HSF-1(-/-)/LDLr (show LDLR ELISA Kits)(-/-) mice to reduce atherosclerosis.
Role of HSF1 in heart failure.HSF1 up-regulation of AC6 (show ADCY6 ELISA Kits).
Findings suggest that PGC1alpha protects against hyperthermia by cooperating with HSF1 in the induction of a transcriptional program devoted to the cellular protection from thermal insults.
Heat stress-associated increase in skeletal muscle mass may be induced by heat shock transcription factor 1 (HSF1) and/or HSF1-mediated stress response that activates muscle satellite cells and Akt (show AKT1 ELISA Kits)/p70S6K (show RPS6KB1 ELISA Kits) signalling pathway
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
, HSTF 1
, heat shock factor protein 1
, heat shock transcription factor 1