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The product of HSF1 is a heat-shock transcription factor. Additionally we are shipping HSF1 Kits (44) and HSF1 Proteins (17) and many more products for this protein.
Showing 10 out of 473 products:
Cow (Bovine) Monoclonal HSF1 Primary Antibody for ELISA, GS - ABIN361704
Monechi, Fiumalbi, De Monte, Della Scala, Citroni, Paolini, Giannelli, Melanil, Barchielli, Pistolesi, Bernetti, Paghi, Valerio, Sagramoni, Guerri, Cannarozzo, Canocchi: [Investigation on health status of silica exposed workers in 'cotto Fiorentino' companies] in Giornale italiano di medicina del lavoro ed ergonomia 2008
Show all 12 references for ABIN361704
Human Polyclonal HSF1 Primary Antibody for EIA, WB - ABIN357730
He, Soncin, Grammatikakis, Li, Siganou, Gong, Brown, Kingston, Calderwood: Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. in The Journal of biological chemistry 2003
Show all 4 references for ABIN357730
Cow (Bovine) Monoclonal HSF1 Primary Antibody for ELISA, GS - ABIN1741569
Cotto, Fox, Morimoto: HSF1 granules: a novel stress-induced nuclear compartment of human cells. in Journal of cell science 1998
Show all 2 references for ABIN1741569
Cow (Bovine) Monoclonal HSF1 Primary Antibody for ELISA, GS - ABIN1741570
McMillan, Xiao, Shao, Graves, Benjamin: Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis. in The Journal of biological chemistry 1998
Show all 2 references for ABIN1741570
Human Polyclonal HSF1 Primary Antibody for IF, WB - ABIN389069
Wang, Grammatikakis, Siganou, Calderwood: Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. in Molecular and cellular biology 2003
Human Monoclonal HSF1 Primary Antibody for EIA, IHC (p) - ABIN263933
Allan, Tyrrell, Rothwell: Interleukin-1 and neuronal injury. in Nature reviews. Immunology 2005
Human Polyclonal HSF1 Primary Antibody for IHC, ELISA - ABIN1532015
Tamaru, Hattori, Ninomiya, Kawamura, Varès, Honda, Mishra, Wang, Benjamin, Sassone-Corsi, Ozawa, Takamatsu: ROS Stress Resets Circadian Clocks to Coordinate Pro-Survival Signals. in PLoS ONE 2013
Human Polyclonal HSF1 Primary Antibody for IHC (p), WB - ABIN658110
Hayashida, Fujimoto, Tan, Prakasam, Shinkawa, Li, Ichikawa, Takii, Nakai: Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT. in The EMBO journal 2010
Cow (Bovine) Polyclonal HSF1 Primary Antibody for WB - ABIN2792576
Wang, He, Yu, Xia, Lin, Gu, Li, Zou, An, Jiang, Kung, Wong: HSF1 down-regulates XAF1 through transcriptional regulation. in The Journal of biological chemistry 2006
Cow (Bovine) Polyclonal HSF1 Primary Antibody for WB - ABIN2779856
Shamovsky, Ivannikov, Kandel, Gershon, Nudler: RNA-mediated response to heat shock in mammalian cells. in Nature 2006
HSF-1 is a codeterminant of both alcohol and nicotine sensitivity in C. elegans and that this phenotype requires the small HSP, HSP-16.48. HSP-16.48 function in drug sensitivity is unrelated to a chaperone action during the heat shock stress response.
Heat-stress-enhanced ascaroside production appears to be mediated at least in part by HSF-1, which seems to be important in adaptation strategies for coping with heat stress in this nematode.
FUdR treatment can modulate the HSR and proteostasis, and should be used with caution when used to inhibit reproduction.
Excitation of the AFD thermosensory neurons is sufficient to activate HSF1 in another cell, even in the absence of temperature increase. Excitation of the AFD thermosensory neurons enhances serotonin release.
hsf-1 RNAi suppressed the restoration of thrashing reduced by heat stress. In contrast, hsf-1 knockdown cancelled prevention of movement reduction in a daf-2 mutant, but didn't suppress thrashing restoration in daf-2 mutant.
we engaged C. elegans mutants and identified that the p38 MAPK (show MAPK14 Antibodies) signaling, insulin (show INS Antibodies)/IGF-1 (show IGF1 Antibodies) signaling (IIS), and HSF-1 play pivotal roles in the WCESP-mediated host immune response
HSF-1 has a prominent role in cytoskeletal integrity, ensuring cellular function during stress and aging. Overexpression of pat-10 increased actin filament stability, thermotolerance, and longevity, indicating that in addition to chaperone regulation, HSF-1 has a prominent role in cytoskeletal integrity, ensuring cellular function during stress and aging.
HSF-1 represses the expression of daf-7 encoding a TGF-beta (show TGFB1 Antibodies) ligand, to induce young larvae to enter the dauer stage, a developmentally arrested, non-feeding, highly stress-resistant, long-lived larval form triggered by crowding and starvation.
required for daf-2-insulin (show INS Antibodies)/IGF-1 (show IGF1 Antibodies) receptor mutations to extend life-span
downstream transcription factors, heat shock factor 1, and DAF-16 regulate opposing disaggregation and aggregation activities to promote cellular survival in response to constitutive toxic Abeta (show APP Antibodies)(1-42) aggregation
HSF-1 ablation not only eliminates heat shock response, but it also transcriptionally up-regulates CYP7A1 (show CYP7A1 Antibodies) and MDR1/P-gp (show ABCB4 Antibodies) axis in WD-diet fed HSF-1(-/-)/LDLr (show LDLR Antibodies)(-/-) mice to reduce atherosclerosis.
Role of HSF1 in heart failure.HSF1 up-regulation of AC6 (show ADCY6 Antibodies).
Findings suggest that PGC1alpha protects against hyperthermia by cooperating with HSF1 in the induction of a transcriptional program devoted to the cellular protection from thermal insults.
Heat stress-associated increase in skeletal muscle mass may be induced by heat shock transcription factor 1 (HSF1) and/or HSF1-mediated stress response that activates muscle satellite cells and Akt (show AKT1 Antibodies)/p70S6K (show RPS6KB1 Antibodies) signalling pathway
Defective Hsf1 inhibits the growth of fibrosarcoma derived from simian virus 40/T antigentransformed mouse embryonic fibroblasts.
Suggest that the early activation of Hsf1 dependent cell stress pathway by mono-allelic mutations in APC (show APC Antibodies) can affect cell programming in a way that contributes to cancer onset.
The pharmacological activation of HSF1 promotes thermogenic and mitochondrial gene programs in brown and beige (show LYST Antibodies) cells and in skeletal muscle, with profound impact on metabolic parameters.
HSF1 is required for myocardial fibrosis in ISO-treated mice, and the underlying molecular mechanism may involve the regulation of HSP47 (show SERPINH1 Antibodies).
Authors have concluded that at the physiological temperature HSF1 and HSF2 cooperate in spermatogenic cells. However, temperature elevation causes remodeling of chromatin binding and interactions between HSFs are disrupted.
A novel regulatory mechanism between Hsf1 and Hsf4b in modulating lens epithelial cell homeostasis.
Heat Shock Factor 1 Depletion Sensitizes A172 Glioblastoma Cells to Temozolomide via Suppression of Cancer Stem Cell-Like Properties.
By showing transcription factor HSF1 activation, we demonstrated that HCA induces the expression of BAG3 (show BAG3 Antibodies) through HSF1 activation. More importantly, knockdown of BAG3 (show BAG3 Antibodies) expression using siRNA largely inhibited HCA-induced apoptosis, suggesting that BAG3 (show BAG3 Antibodies) is actively involved in HCA-induced cancer cell death
miR (show MLXIP Antibodies)-34b suppressed AML (show RUNX1 Antibodies) cell proliferation and survival by targeting HSF1, in turn leading to the inactivation of Wnt (show WNT2 Antibodies)-beta-catenin (show CTNNB1 Antibodies) pathway, which may highlight a new therapeutic approach for AML (show RUNX1 Antibodies).
The evidence of genetic associations has been found for the multivariate response phenotype that involves trans effects modulating expression of genes following heat shock, including HSF1 and UBQLN1 (show UBQLN1 Antibodies).
M3-mAChR (show CHRM3 Antibodies) activation leads to enhancement of hsp expression via PKC (show PRRT2 Antibodies)-dependent phosphorylation of HSF1, thereby stabilizing the mutant hERG (show KCNH2 Antibodies)-FLAG protein. Thus, M3-mAChR (show CHRM3 Antibodies) activators may have a therapeutic value for patients with LQT2 (show KCNH2 Antibodies).
Oncogenic signaling mobilizes HSF1, cancer cells rely on HSF1 to avert proteomic instability and repress tumor-suppressive amyloidogenesis. [review]
These results reveal the existence of a novel IER5 (show IER5 Antibodies)-mediated cancer regulation pathway that is responsible for the activation of HSF1 observed in various cancers.
The authors found a temperature-dependent unfolding of Hsf1 in the regulatory region happening concomitant to tighter packing in the trimerization region.
Ginsenoside Rg3 induces FUT4 (show FUT4 Antibodies)-mediated apoptosis in H. pylori CagA (show S100A8 Antibodies)-treated gastric cancer cells by regulating SP1 (show PSG1 Antibodies) and HSF1 expressions
Aberrant HSF1 degradation is a key neurodegenerative mechanism underlying alpha-synucleinopathy. Elevated NEDD4 is implicated as the responsible ubiquitin E3 ligase for HSF1 degradation through ubiquitin-proteasome system.
As the 4693-T mutation caused the disruption of microRNA target binding (resulting in the relief of the transcriptional repression), the HSF1 gene is useful in dairy cattle thermal tolerant breeding.
HSF1 is a key trans-acting factor for counteracting transgene promoter silencing in Chlamydomonas.
Data show that activated HSF1 and CRR1 transcription factors mediate the acetylation of histones H3/4, nucleosome eviction, remodeling of the H3K4 mono- and dimethylation marks, and transcription initiation/elongation.
data suggest that HSF1 is a key regulator of the stress response in Chlamydomonas
Data suggest that myocardial HSF1 and HSP70 (show HSP70 Antibodies) (70 kDa heat-shock protein (show HSPA9 Antibodies)) can be up-regulated by dietary factors (here, antioxidant taurine as a dietary supplement administered to counteract effects of atherogenic diet).
The results indicate that Heat shock protein 70 (Hsp70) mediates distinct stress-related functions in different tissues during transportation. Heat shock factor-1 (HSF-1) levels were reduced at 1 and 4 h only in the hearts of transported pigs.
The transcriptional up-regulation of unc45b, hsp90aa1.1 and smyd1b is specific to zebrafish mutants with myosin folding defects, and is not triggered in other zebrafish myopathy models
data suggest that HSF1 is involved in regulating constitutive lens specific expression of hsp70 (show HSPA1A Antibodies) in the embryonic zebrafish
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene.
heat shock factor protein
, heat shock transcription factor
, Heat Shock Factor family member (hsf-1)
, HSF 1
, HSTF 1
, heat shock factor protein 1
, heat shock transcription factor 1