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The product of HSF1 is a heat-shock transcription factor. Additionally we are shipping HSF1 Kits (47) and HSF1 Proteins (16) and many more products for this protein.
Showing 10 out of 458 products:
Cow (Bovine) Monoclonal HSF1 Primary Antibody for ELISA, GS - ABIN361704
Monechi, Fiumalbi, De Monte, Della Scala, Citroni, Paolini, Giannelli, Melanil, Barchielli, Pistolesi, Bernetti, Paghi, Valerio, Sagramoni, Guerri, Cannarozzo, Canocchi: [Investigation on health status of silica exposed workers in 'cotto Fiorentino' companies] in Giornale italiano di medicina del lavoro ed ergonomia 2008
Show all 12 references for 361704
Human Polyclonal HSF1 Primary Antibody for EIA, WB - ABIN357730
He, Soncin, Grammatikakis, Li, Siganou, Gong, Brown, Kingston, Calderwood: Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. in The Journal of biological chemistry 2003
Show all 4 references for 357730
Cow (Bovine) Monoclonal HSF1 Primary Antibody for ELISA, GS - ABIN1741570
Cotto, Fox, Morimoto: HSF1 granules: a novel stress-induced nuclear compartment of human cells. in Journal of cell science 1998
Show all 2 references for 1741570
Human Polyclonal HSF1 Primary Antibody for IF, WB - ABIN389069
Wang, Grammatikakis, Siganou, Calderwood: Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. in Molecular and cellular biology 2003
Human Monoclonal HSF1 Primary Antibody for EIA, IHC (p) - ABIN263933
Allan, Tyrrell, Rothwell: Interleukin-1 and neuronal injury. in Nature reviews. Immunology 2005
Cow (Bovine) Polyclonal HSF1 Primary Antibody for WB - ABIN2779857
Shamovsky, Ivannikov, Kandel, Gershon, Nudler: RNA-mediated response to heat shock in mammalian cells. in Nature 2006
Human Polyclonal HSF1 Primary Antibody for IHC (p), WB - ABIN658110
Hayashida, Fujimoto, Tan, Prakasam, Shinkawa, Li, Ichikawa, Takii, Nakai: Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT. in The EMBO journal 2010
Cow (Bovine) Polyclonal HSF1 Primary Antibody for WB - ABIN2792576
Wang, He, Yu, Xia, Lin, Gu, Li, Zou, An, Jiang, Kung, Wong: HSF1 down-regulates XAF1 through transcriptional regulation. in The Journal of biological chemistry 2006
Human Polyclonal HSF1 Primary Antibody for IHC, ELISA - ABIN1532015
Tamaru, Hattori, Ninomiya, Kawamura, Varès, Honda, Mishra, Wang, Benjamin, Sassone-Corsi, Ozawa, Takamatsu: ROS Stress Resets Circadian Clocks to Coordinate Pro-Survival Signals. in PLoS ONE 2013
We demonstrate that while DAF-16/FOXO is dispensable, the age-dependent suppression of cilia phenotypes in IFT mutants requires cell-autonomous functions of the HSF1 heat shock factor and the Hsp90 chaperone
HSF-1 is a codeterminant of both alcohol and nicotine sensitivity in C. elegans and that this phenotype requires the small HSP, HSP-16.48. HSP-16.48 function in drug sensitivity is unrelated to a chaperone action during the heat shock stress response.
Heat-stress-enhanced ascaroside production appears to be mediated at least in part by HSF-1, which seems to be important in adaptation strategies for coping with heat stress in this nematode.
FUdR treatment can modulate the HSR and proteostasis, and should be used with caution when used to inhibit reproduction.
Excitation of the AFD thermosensory neurons is sufficient to activate HSF1 in another cell, even in the absence of temperature increase. Excitation of the AFD thermosensory neurons enhances serotonin release.
hsf-1 RNAi suppressed the restoration of thrashing reduced by heat stress. In contrast, hsf-1 knockdown cancelled prevention of movement reduction in a daf-2 mutant, but didn't suppress thrashing restoration in daf-2 mutant.
we engaged C. elegans mutants and identified that the p38 MAPK (show MAPK14 Antibodies) signaling, insulin (show INS Antibodies)/IGF-1 (show IGF1 Antibodies) signaling (IIS), and HSF-1 play pivotal roles in the WCESP-mediated host immune response
HSF-1 has a prominent role in cytoskeletal integrity, ensuring cellular function during stress and aging. Overexpression of pat-10 increased actin filament stability, thermotolerance, and longevity, indicating that in addition to chaperone regulation, HSF-1 has a prominent role in cytoskeletal integrity, ensuring cellular function during stress and aging.
HSF-1 represses the expression of daf-7 encoding a TGF-beta (show TGFB1 Antibodies) ligand, to induce young larvae to enter the dauer stage, a developmentally arrested, non-feeding, highly stress-resistant, long-lived larval form triggered by crowding and starvation.
required for daf-2-insulin (show INS Antibodies)/IGF-1 (show IGF1 Antibodies) receptor mutations to extend life-span
Upregulating HSF1 relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP (show DDIT3 Antibodies) and increasing HSP70 (show HSP70 Antibodies) a5 (BiP/GRP78 (show HSPA5 Antibodies)). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 being one likely key player in both systems.
HSF1 translationally augments the proteotoxic stress response.
HSF1 as a central regulator of cellular bioenergetics.
have demonstrated that the levels of HSF1 and heat shock proteins are significantly reduced in affected neuronal tissues from a TDP-43 (show TARDBP Antibodies) transgenic mouse model of amyotrophic lateral sclerosis and patients with sporadic amyotrophic lateral sclerosis.
HSF-1 ablation not only eliminates heat shock response, but it also transcriptionally up-regulates CYP7A1 (show CYP7A1 Antibodies) and MDR1/P-gp (show ABCB4 Antibodies) axis in WD-diet fed HSF-1(-/-)/LDLr (show LDLR Antibodies)(-/-) mice to reduce atherosclerosis.
Role of HSF1 in heart failure.HSF1 up-regulation of AC6 (show ADCY6 Antibodies).
Findings suggest that PGC1alpha protects against hyperthermia by cooperating with HSF1 in the induction of a transcriptional program devoted to the cellular protection from thermal insults.
Heat stress-associated increase in skeletal muscle mass may be induced by heat shock transcription factor 1 (HSF1) and/or HSF1-mediated stress response that activates muscle satellite cells and Akt (show AKT1 Antibodies)/p70S6K (show RPS6KB1 Antibodies) signalling pathway
Defective Hsf1 inhibits the growth of fibrosarcoma derived from simian virus 40/T antigentransformed mouse embryonic fibroblasts.
Suggest that the early activation of Hsf1 dependent cell stress pathway by mono-allelic mutations in APC (show APC Antibodies) can affect cell programming in a way that contributes to cancer onset.
Studies indicate correlations between heat shock transcription factor 1 (HSF1) activity and the incidence of several cancer types.
These findings suggest that HSF1 is important in the ovarian cancer TGFbeta (show TGFB1 Antibodies) response and in Epithelial-Mesenchymal Transition.
BRD4 (show BRD4 Antibodies) regulates splicing during heat shock by interacting with HSF1 such that under heat stress BRD4 (show BRD4 Antibodies) is recruited to nuclear stress bodies, and non-coding SatIII RNA transcripts are up-regulated.
Results demonstrate that p38 MAPK (show MAPK14 Antibodies) not only causes phosphorylation of HSF1 at S326 but also at S303/307 , and transcriptionally activates HSF1.
Heat Shock Factor 1 Depletion Sensitizes A172 Glioblastoma Cells to Temozolomide via Suppression of Cancer Stem Cell-Like Properties.
By showing transcription factor HSF1 activation, we demonstrated that HCA induces the expression of BAG3 (show BAG3 Antibodies) through HSF1 activation. More importantly, knockdown of BAG3 (show BAG3 Antibodies) expression using siRNA largely inhibited HCA-induced apoptosis, suggesting that BAG3 (show BAG3 Antibodies) is actively involved in HCA-induced cancer cell death
miR (show MLXIP Antibodies)-34b suppressed AML (show RUNX1 Antibodies) cell proliferation and survival by targeting HSF1, in turn leading to the inactivation of Wnt (show WNT2 Antibodies)-beta-catenin (show CTNNB1 Antibodies) pathway, which may highlight a new therapeutic approach for AML (show RUNX1 Antibodies).
The evidence of genetic associations has been found for the multivariate response phenotype that involves trans effects modulating expression of genes following heat shock, including HSF1 and UBQLN1 (show UBQLN1 Antibodies).
M3-mAChR (show CHRM3 Antibodies) activation leads to enhancement of hsp expression via PKC (show PRRT2 Antibodies)-dependent phosphorylation of HSF1, thereby stabilizing the mutant hERG (show KCNH2 Antibodies)-FLAG protein. Thus, M3-mAChR (show CHRM3 Antibodies) activators may have a therapeutic value for patients with LQT2 (show KCNH2 Antibodies).
As the 4693-T mutation caused the disruption of microRNA target binding (resulting in the relief of the transcriptional repression), the HSF1 gene is useful in dairy cattle thermal tolerant breeding.
HSF1 is a key trans-acting factor for counteracting transgene promoter silencing in Chlamydomonas.
Data show that activated HSF1 and CRR1 transcription factors mediate the acetylation of histones H3/4, nucleosome eviction, remodeling of the H3K4 mono- and dimethylation marks, and transcription initiation/elongation.
data suggest that HSF1 is a key regulator of the stress response in Chlamydomonas
Data suggest that myocardial HSF1 and HSP70 (show HSP70 Antibodies) (70 kDa heat-shock protein (show HSPA9 Antibodies)) can be up-regulated by dietary factors (here, antioxidant taurine as a dietary supplement administered to counteract effects of atherogenic diet).
The results indicate that Heat shock protein 70 (Hsp70) mediates distinct stress-related functions in different tissues during transportation. Heat shock factor-1 (HSF-1) levels were reduced at 1 and 4 h only in the hearts of transported pigs.
The transcriptional up-regulation of unc45b, hsp90aa1.1 and smyd1b is specific to zebrafish mutants with myosin folding defects, and is not triggered in other zebrafish myopathy models
data suggest that HSF1 is involved in regulating constitutive lens specific expression of hsp70 (show HSPA1A Antibodies) in the embryonic zebrafish
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene.
heat shock factor protein
, heat shock transcription factor
, Heat Shock Factor family member (hsf-1)
, HSF 1
, HSTF 1
, heat shock factor protein 1
, heat shock transcription factor 1