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HSP encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. Additionally we are shipping Heat Shock Protein Antibodies (28) and Heat Shock Protein Kits (1) and many more products for this protein.
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overexpression of SelK can inhibit human cancer cell Matrigel adhesion and migration
IP3R palmitoylation is a critical regulator of Ca(2+) flux in immune cells and define a previously unidentified DHHC/Selk complex responsible for this process.
SelK reduces hydrophobic substrates, such as phospholipid hydroperoxides, which are known to damage cell membranes.
Polymorphisms in thioredoxin reductase (show PRDX5 Proteins) and selenoprotein K genes and selenium status modulate risk of prostate cancer
Data suggest that SelK is involved in the Derlin-dependent ERAD of glycosylated misfolded proteins and that the function defined by the prototypic SelK is the widespread function of selenium in eukaryotes.
Human lymphocyte SelK colocalizes with endoplasmic reticulum (show CCR1 Proteins) biomarker KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum receptor.
SelK is a novel antioxidant in cardiomyocytes and is related to the regulation of cellular redox balance.
interaction between SelK and p97(VCP (show vcp Proteins)) is SelS (show SELS Proteins)-dependent, and the resulting ERAD complex (SelS (show SELS Proteins)-p97(VCP (show vcp Proteins))-SelK) plays an important role in ERAD and ER stress
Selk deficiency through genetic deletion or low selenium in culture media leads to low expression of the IP3R due to a defect in IP3R palmitoylation. DHHC6/Selk interactions in the ER membrane depend on SH3/SH3 binding domain interactions.
Selk is important for stable, localized expression of CD36 (show CD36 Proteins) in macrophages during inflammation, thereby contributing to foam cell formation and atherogenesis.
Selenoprotein K is a novel target of m-calpain (show CAPN2 Proteins), and cleavage is regulated by Toll (show TLR4 Proteins)-like receptor 2,3,4 and 9-induced calpastatin (show CAST Proteins) in macrophages
Sel K-deficient T cells exhibit decreased chemokine receptor (show CCR1 Proteins)-mediated calcium flux.
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant.
Heat Shock Protein family member (hsp-25)
, heat shock protein
, heat shock protein, 30 kDa