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HSP encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. Additionally we are shipping Heat Shock Protein Proteins (9) and Heat Shock Protein Kits (1) and many more products for this protein.
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Human Polyclonal HSP Primary Antibody for WB - ABIN657518
Fredericks, Hoffmann, Rose, Osterheld, Hess, Mercier, Hoffmann: Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. in Proceedings of the National Academy of Sciences of the United States of America 2014
miR (show MLXIP Antibodies)-544a expression was found to be modulated by selenium treatment, suggesting a possible role in SELK induction by selenium.
These results hereby imply SelK may regulate the release of Ca(2+) by CHERP and play an important role in the proliferation and differentiation of T cell by TCR stimulation.
SELK has the dynamic structural features to be defined as a HUB protein able to interact with multiple members.
overexpression of SelK can inhibit human cancer cell Matrigel adhesion and migration
IP3R palmitoylation is a critical regulator of Ca(2+) flux in immune cells and define a previously unidentified DHHC/Selk complex responsible for this process.
SelK reduces hydrophobic substrates, such as phospholipid hydroperoxides, which are known to damage cell membranes.
Polymorphisms in thioredoxin reductase (show PRDX5 Antibodies) and selenoprotein K genes and selenium status modulate risk of prostate cancer
Data suggest that SelK is involved in the Derlin-dependent ERAD of glycosylated misfolded proteins and that the function defined by the prototypic SelK is the widespread function of selenium in eukaryotes.
Human lymphocyte SelK colocalizes with endoplasmic reticulum (show CCR1 PLURAL_@9242@) biomarker KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum receptor.
SelK is a novel antioxidant in cardiomyocytes and is related to the regulation of cellular redox balance.
these findings identify ASAP2 (show ASAP2 Antibodies) as a new target of Selk-dependent palmitoylation and reveal a new mechanism regulating the efficiency of FcgammaR-mediated phagocytosis.
interaction between SelK and p97(VCP (show vcp Antibodies)) is SelS (show SELS Antibodies)-dependent, and the resulting ERAD complex (SelS (show SELS Antibodies)-p97(VCP (show vcp Antibodies))-SelK) plays an important role in ERAD and ER stress
Selk deficiency through genetic deletion or low selenium in culture media leads to low expression of the IP3R due to a defect in IP3R palmitoylation. DHHC6/Selk interactions in the ER membrane depend on SH3/SH3 binding domain interactions.
Selk is important for stable, localized expression of CD36 (show CD36 Antibodies) in macrophages during inflammation, thereby contributing to foam cell formation and atherogenesis.
Selenoprotein K is a novel target of m-calpain (show CAPN2 Antibodies), and cleavage is regulated by Toll (show TLR4 Antibodies)-like receptor 2,3,4 and 9-induced calpastatin (show CAST Antibodies) in macrophages
Sel K-deficient T cells exhibit decreased chemokine receptor (show CCR1 PLURAL_@9242@)-mediated calcium flux.
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant.
Heat Shock Protein family member (hsp-25)
, heat shock protein
, heat shock protein, 30 kDa