anti-Heat Shock Protein 90, Beta, Member 1 (HSP90B1) Antibodies

HSP90B1 encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family.

list all antibodies Gene Name GeneID UniProt
Anti-Human HSP90B1 HSP90B1 8295 Q9Y4A5
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More Antibodies against Heat Shock Protein 90, Beta, Member 1 Interaction Partners

Human Heat Shock Protein 90, Beta, Member 1 (HSP90B1) interaction partners

  1. Data suggest that ubiquitin thioesterase 7 (HAUSP (show USP7 Antibodies)) may act as an oncogenic protein that can modulate c-MYC (show MYC Antibodies) protein expression via transformation-transcription domain-associated protein (TRRAP (show TRRAP Antibodies)).

  2. study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP (show CREBBP Antibodies), CBFA2T3 (show CBFA2T3 Antibodies), AMOTL1 (show AMOTL1 Antibodies), FAT4 (show FAT4 Antibodies), FBXO11 (show FBXO11 Antibodies), PLA2G4D, TRRAP (show TRRAP Antibodies) and USH2A (show USH2A Antibodies).

  3. MYC associates with STAGA through extended interactions of the TAD with both TRRAP and GCN5.

  4. Findings establish Trrap (show TRRAP Antibodies) as a critical part of the mechanism that restricts differentiation and promotes the maintenance of key features of ESCs (show NR2E3 Antibodies).

  5. TRRAP (show TRRAP Antibodies) is targeted for destruction in a cell cycle-dependent fashion.

  6. The over-expression of TRA1 in hepatocirrhosis and hepatocellular carcinoma is correlated with the formation and development of HCC (show FAM126A Antibodies).

  7. TRRAP (show TRRAP Antibodies) harbors a recurrent mutation that clustered in one position (p. Ser722Phe) in 6 out of 167 melanoma samples (approx. 4%). The nature, pattern and functional evaluation of the TRRAP (show TRRAP Antibodies) recurrent mutation suggest that TRRAP (show TRRAP Antibodies) functions as an oncogene (show RAB1A Antibodies).

  8. knockdown of the adaptor protein TRRAP (show TRRAP Antibodies) significantly increased differentiation of cultured brain tumor-initiating cells, sensitized the cells to apoptotic stimuli, and negatively affected cell cycle progression.

  9. TRRAP (show TRRAP Antibodies) binding and the recruitment of histone H3 (show HIST3H3 Antibodies) and H4 acetyltransferase activities are required for the transactivation of a silent TERT (show TERT Antibodies) gene in exponentially growing human fibroblasts by c-Myc (show MYC Antibodies) or N-Myc protein (show MYCN Antibodies).

  10. Data suggest a model in which p53 (show TP53 Antibodies) directly recruits a TRRAP (show TRRAP Antibodies)/acetyltransferase complex to the mdm2 (show MDM2 Antibodies) gene to activate transcription. In addition, this study defines a novel mechanism utilized by the p53 tumor suppressor (show TP53 Antibodies) to regulate gene expression.

Heat Shock Protein 90, Beta, Member 1 (HSP90B1) Antigen Profile

Protein Summary

This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with HSP90B1

  • transformation/transcription domain-associated protein (TRRAP) antibody
  • PAF350/400 antibody
  • PAF400 antibody
  • STAF40 antibody
  • TR-AP antibody
  • Tra1 antibody

Protein level used designations for HSP90B1

350/400 kDa PCAF-associated factor , tra1 homolog

8295 Homo sapiens
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