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HERC2 belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains.
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Human Monoclonal HERC2 Primary Antibody for WB - ABIN968838
Ji, Rebert, Joslin, Higgins, Schultz, Nicholls: Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human. in Genome research 2000
Show all 2 references for ABIN968838
identified HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33 (show USP33 Antibodies).
HERC2 acts as a regulator of E6AP (show ube3a Antibodies).
Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.
Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal.
Results identify HERC2 as a regulator of p53 (show TP53 Antibodies) signaling.
results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism
ATR (show ANTXR1 Antibodies)-mediated phosphorylation induces XPA (show XPA Antibodies) stabilization by antagonizing HERC2-catalyzed XPA (show XPA Antibodies) ubiquitination.
given a particular HERC2/OCA2 genotype, males are more prone to have lighter eye colors than predicted by their genotypes, while females tend to have darker eye colors than predicted
Studied an autosomal-recessive neurodevelopmental disorder with some phenotypic similarities to Angelman syndrome (show ube3a Antibodies), found among the Old Order Amish. Our molecular investigation identified a mutation in HERC2 associated with the disease phenotype.
Pathogenic changes in HERC2 are associated with nonsyndromic intellectual disability, autism, and gait disturbance.
the NEURL4-HERC2 complex participates in the ubiquitin-dependent regulation of centrosome architecture
This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16.
, E3 ubiquitin-protein ligase HERC2
, HECT domain and RCC1-like domain-containing protein 2
, probable E3 ubiquitin-protein ligase HERC2
, hect domain and RCC1-like domain-containing protein 2
, hect domain and RLD 2