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anti-Hect Domain and RLD 2 (HERC2) Antibodies

HERC2 belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains.

list all antibodies Gene Name GeneID UniProt
HERC2 15204 Q4U2R1
HERC2 8924 O95714
HERC2    
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Top anti-HERC2 Antibodies at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB Western blot analysis of HERC2 on mouse cerebellum. Lane 1: 250, lane 2:5000, land 3: 1:1000 dilution of HERC2. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 5 to 7 Days
$477.75
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Biotin IHC (p), WB   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit HRP IHC (p), WB   100 μL Log in to see 14 to 21 Days
$379.50
Details

HERC2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


Human , ,
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Rat (Rattus)


Top referenced anti-HERC2 Antibodies

  1. Human Monoclonal HERC2 Primary Antibody for WB - ABIN968838 : Ji, Rebert, Joslin, Higgins, Schultz, Nicholls: Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human. in Genome research 2000 (PubMed)
    Show all 2 references for ABIN968838

More Antibodies against HERC2 Interaction Partners

Mouse (Murine) Hect Domain and RLD 2 (HERC2) interaction partners

  1. identified HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33 (show USP33 Antibodies).

  2. HERC2 acts as a regulator of E6AP (show ube3a Antibodies).

Human Hect Domain and RLD 2 (HERC2) interaction partners

  1. Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.

  2. Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal.

  3. Results identify HERC2 as a regulator of p53 (show TP53 Antibodies) signaling.

  4. results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism

  5. identified HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33 (show USP33 Antibodies).

  6. ATR (show ANTXR1 Antibodies)-mediated phosphorylation induces XPA (show XPA Antibodies) stabilization by antagonizing HERC2-catalyzed XPA (show XPA Antibodies) ubiquitination.

  7. given a particular HERC2/OCA2 genotype, males are more prone to have lighter eye colors than predicted by their genotypes, while females tend to have darker eye colors than predicted

  8. Studied an autosomal-recessive neurodevelopmental disorder with some phenotypic similarities to Angelman syndrome (show ube3a Antibodies), found among the Old Order Amish. Our molecular investigation identified a mutation in HERC2 associated with the disease phenotype.

  9. Pathogenic changes in HERC2 are associated with nonsyndromic intellectual disability, autism, and gait disturbance.

  10. the NEURL4-HERC2 complex participates in the ubiquitin-dependent regulation of centrosome architecture

HERC2 Antigen Profile

Protein Summary

This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16.

Gene names and symbols associated with HERC2

  • CG11734 gene product from transcript CG11734-RC (HERC2) antibody
  • hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2 (Herc2) antibody
  • HECT and RLD domain containing E3 ubiquitin protein ligase 2 (HERC2) antibody
  • CG11734 antibody
  • D7H15F32S1 antibody
  • D7H15F37S1 antibody
  • D15F32S1h antibody
  • D15F37S1 antibody
  • Dmel\\CG11734 antibody
  • jdf2 antibody
  • mKIAA0393 antibody
  • p528 antibody
  • rjs antibody
  • SHEP1 antibody

Protein level used designations for HERC2

CG11734-PC , HERC2-PC , E3 ubiquitin-protein ligase HERC2 , HECT domain and RCC1-like domain-containing protein 2 , probable E3 ubiquitin-protein ligase HERC2 , hect domain and RCC1-like domain-containing protein 2 , hect domain and RLD 2

GENE ID SPECIES
33035 Drosophila melanogaster
15204 Mus musculus
8924 Homo sapiens
Selected quality suppliers for anti-HERC2 (HERC2) Antibodies
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