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HERC2 belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains.
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Human Monoclonal HERC2 Primary Antibody for WB - ABIN968838
Ji, Rebert, Joslin, Higgins, Schultz, Nicholls: Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human. in Genome research 2000
Show all 2 references for ABIN968838
identified HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33 (show USP33 Antibodies).
HERC2 acts as a regulator of E6AP (show ube3a Antibodies).
SNP rs12913832 in HERC2 was found to be strongly associated with blue eye colour. SNP associations with hair and skin colour were weaker and genotypes less predictive.
Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.
Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal.
Results identify HERC2 as a regulator of p53 (show TP53 Antibodies) signaling.
results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism
ATR (show ANTXR1 Antibodies)-mediated phosphorylation induces XPA (show XPA Antibodies) stabilization by antagonizing HERC2-catalyzed XPA (show XPA Antibodies) ubiquitination.
given a particular HERC2/OCA2 genotype, males are more prone to have lighter eye colors than predicted by their genotypes, while females tend to have darker eye colors than predicted
Studied an autosomal-recessive neurodevelopmental disorder with some phenotypic similarities to Angelman syndrome (show ube3a Antibodies), found among the Old Order Amish. Our molecular investigation identified a mutation in HERC2 associated with the disease phenotype.
Pathogenic changes in HERC2 are associated with nonsyndromic intellectual disability, autism, and gait disturbance.
This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16.
, E3 ubiquitin-protein ligase HERC2
, HECT domain and RCC1-like domain-containing protein 2
, probable E3 ubiquitin-protein ligase HERC2
, hect domain and RCC1-like domain-containing protein 2
, hect domain and RLD 2