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anti-Hect Domain and RLD 2 (HERC2) Antibodies

HERC2 belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains.

list all antibodies Gene Name GeneID UniProt
HERC2 15204 Q4U2R1
HERC2 8924 O95714
HERC2    
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Top anti-HERC2 Antibodies at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB Western blot analysis of HERC2 on mouse cerebellum. Lane 1: 250, lane 2:5000, land 3: 1:1000 dilution of HERC2. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated WB Western Blot: HERC2 Antibody [NBP1-05970] - Detection of Mouse HERC2- Whole cell lysate (50 ug) from NIH3T3, TCMK-1, Renca, 4T1, and CT26.WT cells. Affinity purified rabbit anti-HERC2 antibody used for WB at 0.5 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. 100 μL Log in to see 5 to 7 Days
$486.94
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry: HERC2 Antibody [NBP2-37922] - Staining of human tonsil shows distinct cytoplasmic positivity in subsets of cells. Immunocytochemistry/Immunofluorescence: HERC2 Antibody [NBP2-37922] - Immunofluorescent staining of human cell line U-2 OS shows positivity in vesicles. 0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Human Rabbit HRP IHC (p), WB   100 μL Log in to see 14 to 21 Days
$379.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Biotin IHC (p), WB   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

HERC2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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,
Human , ,
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Rat (Rattus)


Top referenced anti-HERC2 Antibodies

  1. Human Monoclonal HERC2 Primary Antibody for WB - ABIN968838 : Ji, Rebert, Joslin, Higgins, Schultz, Nicholls: Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human. in Genome research 2000 (PubMed)
    Show all 2 references for ABIN968838

More Antibodies against HERC2 Interaction Partners

Mouse (Murine) Hect Domain and RLD 2 (HERC2) interaction partners

  1. identified HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33 (show USP33 Antibodies).

  2. HERC2 acts as a regulator of E6AP (show ube3a Antibodies).

Human Hect Domain and RLD 2 (HERC2) interaction partners

  1. SNP rs12913832 in HERC2 was found to be strongly associated with blue eye colour. SNP associations with hair and skin colour were weaker and genotypes less predictive.

  2. Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.

  3. Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal.

  4. Results identify HERC2 as a regulator of p53 (show TP53 Antibodies) signaling.

  5. results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism

  6. identified HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33 (show USP33 Antibodies).

  7. ATR (show ANTXR1 Antibodies)-mediated phosphorylation induces XPA (show XPA Antibodies) stabilization by antagonizing HERC2-catalyzed XPA (show XPA Antibodies) ubiquitination.

  8. given a particular HERC2/OCA2 genotype, males are more prone to have lighter eye colors than predicted by their genotypes, while females tend to have darker eye colors than predicted

  9. Studied an autosomal-recessive neurodevelopmental disorder with some phenotypic similarities to Angelman syndrome (show ube3a Antibodies), found among the Old Order Amish. Our molecular investigation identified a mutation in HERC2 associated with the disease phenotype.

  10. Pathogenic changes in HERC2 are associated with nonsyndromic intellectual disability, autism, and gait disturbance.

HERC2 Antigen Profile

Protein Summary

This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16.

Gene names and symbols associated with HERC2

  • CG11734 gene product from transcript CG11734-RC (HERC2) antibody
  • hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2 (Herc2) antibody
  • HECT and RLD domain containing E3 ubiquitin protein ligase 2 (HERC2) antibody
  • CG11734 antibody
  • D7H15F32S1 antibody
  • D7H15F37S1 antibody
  • D15F32S1h antibody
  • D15F37S1 antibody
  • Dmel\\CG11734 antibody
  • jdf2 antibody
  • mKIAA0393 antibody
  • p528 antibody
  • rjs antibody
  • SHEP1 antibody

Protein level used designations for HERC2

CG11734-PC , HERC2-PC , E3 ubiquitin-protein ligase HERC2 , HECT domain and RCC1-like domain-containing protein 2 , probable E3 ubiquitin-protein ligase HERC2 , hect domain and RCC1-like domain-containing protein 2 , hect domain and RLD 2

GENE ID SPECIES
33035 Drosophila melanogaster
15204 Mus musculus
8924 Homo sapiens
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