Hect Domain and RLD 2 (HERC2) ELISA Kits

HERC2 belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. Additionally we are shipping HERC2 Antibodies (19) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse HERC2 HERC2 15204 Q4U2R1
Anti-Human HERC2 HERC2 8924 O95714
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More ELISA Kits for HERC2 Interaction Partners

Mouse (Murine) Hect Domain and RLD 2 (HERC2) interaction partners

  1. identified HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33 (show USP33 ELISA Kits).

  2. HERC2 acts as a regulator of E6AP (show ube3a ELISA Kits).

Human Hect Domain and RLD 2 (HERC2) interaction partners

  1. Evaluated the association of seven OCA2-HERC2 SNPs and haplotypes with pigmentation characteristics (eye, skin, hair and freckles) in the highly admixed and phenotypically heterogeneous Brazilian population. Such SNPs and haplotypes could be deemed as good predictors for the presence of freckles and for skin, eye and hair pigmentation in the Brazilian population.

  2. We showed that loss of HERC2 function leads to the accumulation of XPA and BRCA1 in the patient's fibroblasts and generates decreased sensitivity to apoptosis and increased level of DNA repair

  3. SNP rs12913832 in HERC2 was found to be strongly associated with blue eye colour. SNP associations with hair and skin colour were weaker and genotypes less predictive.

  4. Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.

  5. Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal.

  6. Results identify HERC2 as a regulator of p53 (show TP53 ELISA Kits) signaling.

  7. results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism

  8. identified HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33 (show USP33 ELISA Kits).

  9. ATR (show ANTXR1 ELISA Kits)-mediated phosphorylation induces XPA (show XPA ELISA Kits) stabilization by antagonizing HERC2-catalyzed XPA (show XPA ELISA Kits) ubiquitination.

  10. given a particular HERC2/OCA2 genotype, males are more prone to have lighter eye colors than predicted by their genotypes, while females tend to have darker eye colors than predicted

HERC2 Antigen Profile

Antigen Summary

This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16.

Gene names and symbols associated with HERC2

  • CG11734 gene product from transcript CG11734-RC (HERC2) antibody
  • hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2 (Herc2) antibody
  • HECT and RLD domain containing E3 ubiquitin protein ligase 2 (HERC2) antibody
  • CG11734 antibody
  • D7H15F32S1 antibody
  • D7H15F37S1 antibody
  • D15F32S1h antibody
  • D15F37S1 antibody
  • Dmel\\CG11734 antibody
  • jdf2 antibody
  • mKIAA0393 antibody
  • p528 antibody
  • rjs antibody
  • SHEP1 antibody

Protein level used designations for HERC2

CG11734-PC , HERC2-PC , E3 ubiquitin-protein ligase HERC2 , HECT domain and RCC1-like domain-containing protein 2 , probable E3 ubiquitin-protein ligase HERC2 , hect domain and RCC1-like domain-containing protein 2 , hect domain and RLD 2

GENE ID SPECIES
33035 Drosophila melanogaster
15204 Mus musculus
8924 Homo sapiens
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