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HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). Additionally we are shipping HERC4 Antibodies (51) and HERC4 Proteins (4) and many more products for this protein.
High HERC4 expression is associated with lung cancer.
HERC4 ancestor emerged in nematodes and that the family expanded throughout evolution. The mRNA expression pattern of the HERC4 was found to be diverse in selected tissues and cells
HERC4 plays an important role in Multiple myeloma progression.
The E3 ubiquitin ligase Herc4, though ubiquitously expressed in all tissues, is most highly expressed in the testis, specifically during spermiogenesis
HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005
hect domain and RLD 4
, probable E3 ubiquitin-protein ligase HERC4
, putative E3 ubiquitin-protein ligase HERC4
, probable E3 ubiquitin-protein ligase HERC4-like
, HECT domain and RCC1-like domain-containing protein 4