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Hematopoietically Expressed Homeobox Proteins (HHEX)

HHEX encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Additionally we are shipping Hematopoietically Expressed Homeobox Antibodies (107) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HHEX 3087 Q03014
HHEX 15242 P43120
Rat HHEX HHEX 79237  
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Top Hematopoietically Expressed Homeobox Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,572.17
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,709.67
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,715.17
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,724.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

HHEX Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Hematopoietically Expressed Homeobox (HHEX) Interaction Partners

Xenopus laevis Hematopoietically Expressed Homeobox (HHEX) interaction partners

  1. Data show that knockdown of hematopoietically expressed homeobox (hhex) resulted in a down-regulation of ventral pancreatic precursor 1 (vpp1 (show ATP6V0A1 Proteins)) expression and a specific loss of the ventral pancreas.

  2. A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer.

Human Hematopoietically Expressed Homeobox (HHEX) interaction partners

  1. Data suggest that hematopoietically expressed homeobox protein (HHEX) downmodulation by promyelocytic leukemia (show PML Proteins)-retinoic acid receptor alpha (show RARA Proteins) fusion oncoprotein (PML (show PML Proteins)-RARalpha (show RARA Proteins)) is a key event during acute promyelocytic leukemia (show PML Proteins) (APL (show FASL Proteins)) pathogenesis.

  2. Hhex binds to the Cdkn2a locus and directly interacts with the Polycomb (show CBX2 Proteins)-repressive complex 2 (PRC2) to enable H3K27me3-mediated epigenetic repression

  3. Data suggest that Hhex is a novel regulator of c-Myc (show MYC Proteins) function that limits c-Myc (show MYC Proteins) activity in transformed cells.

  4. PRH controls the migration of multiple epithelial cell lineages in part at least through the direct transcriptional regulation of Endoglin (show ENG Proteins)

  5. HHEX promotes hepatic specification by repressing EOMES (show EOMES Proteins) expression.

  6. Data indicate the potential importance of CDKAL1 (show CDKAL1 Proteins) protein and homeobox protein HHEX in glucose homeostasis in this Alaska Native population with a low prevalence of type 2 diabetes (T2D).

  7. In all the CHD (show CHDH Proteins) patients, we did not find any causative mutations in the coding region of the HHEX gene.

  8. Tissue-specific knockdown of the HHEX ortholog dHHEX (CG7056) directed metabolic defects and enhanced lethality; for example, fat-body-specific loss of dHHEX led to increased hemolymph glucose and reduced insulin (show INS Proteins) sensitivity

  9. In conclusion, this epistatic interaction showed a high degree of consistency when stratifying by sex, the epsilon4 allele of apolipoprotein E (show APOE Proteins) genotype, and geographic region.

  10. Data indicate associations of SNPs in eight loci CXCR4, HHEX, FOXA2, NGN3, TCF7L2, FLJ39370 (C4orf32), LOC646279 (RPL21P7) and THADA with body mass index (BMI) and weight.

Mouse (Murine) Hematopoietically Expressed Homeobox (HHEX) interaction partners

  1. Hhex(-/-) mESCs fail to differentiate from definitive endoderm to hepatic endoderm.

  2. results implicate Hhex in the maintenance of LT-HSCs and in lineage allocation from multipotent progenitors especially in stress hematopoiesis.

  3. Data suggest that Hhex is a novel regulator of c-Myc (show MYC Proteins) function that limits c-Myc (show MYC Proteins) activity in transformed cells.

  4. Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2 (show LMO2 Proteins)-transgenic mice.

  5. Hhex is a key regulator of early lymphoid development, functioning, at least in part, via regulation of the cell cycle.

  6. Hhex and Cer1 (show CER1 Proteins) are indispensable components of the Sox17 (show SOX17 Proteins) pathway for cardiopoiesis.

  7. Hhex as the first transcriptional regulator specifically required for islet delta cells and suggest compromised paracrine control as a contributor to T2DM

  8. Data suggest that GPC3 (show GPC3 Proteins) down-regulates hepatocyte proliferation by binding to hedgehog (show SHH Proteins) (HH) and down-regulating the HH signaling pathway and binding with CD81 (show CD81 Proteins), thus making it unavailable to bind to Hhex and causing its nuclear translocation.

  9. Hex expression and subcellular localization are associated with chondrocyte maturation

  10. Loss of Hhex is associated with reduction in hematopoietic maturation accompanied by reduced proliferation.

Zebrafish Hematopoietically Expressed Homeobox (HHEX) interaction partners

  1. hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors.

  2. Data suggest that zebrafish hhex appears to be activated by Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) in the dorsal yolk syncytial layer, where bozozok acts in a permissive way to limit repression of hhex by Vega1 and Vega2.

Hematopoietically Expressed Homeobox (HHEX) Protein Profile

Protein Summary

This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.

Gene names and symbols associated with HHEX

  • Homeobox protein PRH (Bm1_31285)
  • Homeobox protein PRH (hhex)
  • hematopoietically expressed homeobox (hhex)
  • hematopoietically expressed homeobox (HHEX)
  • hematopoietically expressed homeobox (Hex1)
  • hematopoietically expressed homeobox (Hhex)
  • HEX protein
  • Hex1 protein
  • HHEX protein
  • hhex-A protein
  • Hhex-rs2 protein
  • HMPH protein
  • HOX11L-PEN protein
  • Prh protein
  • Prhx protein
  • PROBOX protein
  • tHex protein
  • XHex protein

Protein level used designations for HHEX

Homeobox protein PRH , hematopoietically-expressed homeobox protein hhex , homeobox protein hex , homeodomain transcription factor , hematopoietically expressed homeobox , hematopoietically-expressed homeobox protein HHEX , homeobox protein HEX , homeobox protein PRH , homeobox, hematopoietically expressed , proline-rich homeodomain-containing transcription factor , hematopoietically expressed homeobox protein , hematopoietically expressed homeobox, related sequence 2 , hematopoietically-expressed homeobox protein Hhex , mHex

GENE ID SPECIES
6101149 Brugia malayi
100305190 Oncorhynchus mykiss
395060 Xenopus (Silurana) tropicalis
450612 Pan troglodytes
7235725 Branchiostoma floridae
100303530 Saccoglossus kowalevskii
373590 Xenopus laevis
3087 Homo sapiens
608175 Canis lupus familiaris
397232 Sus scrofa
539542 Bos taurus
15242 Mus musculus
79237 Rattus norvegicus
396182 Gallus gallus
30098 Danio rerio
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