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HHEX encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Additionally we are shipping Hematopoietically Expressed Homeobox Antibodies (120) and Hematopoietically Expressed Homeobox Proteins (9) and many more products for this protein.
Data show that knockdown of hematopoietically expressed homeobox (hhex) resulted in a down-regulation of ventral pancreatic precursor 1 (vpp1 (show ATP6V0A1 ELISA Kits)) expression and a specific loss of the ventral pancreas.
A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer.
Vascular smooth muscle protein kinase CK2 (show CSNK2A1 ELISA Kits) inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.
HHEX over expression induced by human cytomegalovirus infection closely associated with vascular proliferative diseases.
The multivariate logistic regression analysis with reference to both alleles and genotypes of CDKAL1 (show CDKAL1 ELISA Kits) SNPs showed significant association, suggesting an important role for this gene in the T2DM pathophysiology. INTERPRETATION & CONCLUSIONS: A significant association was seen of all the three SNPs of CDKAL1 (show CDKAL1 ELISA Kits) and CDKN2A/B genes with T2DM but none of the two SNPs of HHEX.
These studies identify uPA (show PRAP1 ELISA Kits)-dependent de-repression of vegfr1 (show FLT1 ELISA Kits) and vegfr2 (show KDR ELISA Kits) gene transcription through binding to HHEX/PRH as a novel mechanism by which uPA (show PRAP1 ELISA Kits) mediates the pro-angiogenic effects of VEGF (show VEGFA ELISA Kits) and identifies a potential new target for control of pathologic angiogenesis.
Low HHEX mutation is associated with Thyroid Dysgenesis.
Data suggest that hematopoietically expressed homeobox protein (HHEX) downmodulation by promyelocytic leukemia (show PML ELISA Kits)-retinoic acid receptor alpha (show RARA ELISA Kits) fusion oncoprotein (PML (show PML ELISA Kits)-RARalpha (show RARA ELISA Kits)) is a key event during acute promyelocytic leukemia (show PML ELISA Kits) (APL (show FASL ELISA Kits)) pathogenesis.
Hhex binds to the Cdkn2a locus and directly interacts with the Polycomb (show CBX2 ELISA Kits)-repressive complex 2 (PRC2) to enable H3K27me3-mediated epigenetic repression
Data suggest that Hhex is a novel regulator of c-Myc (show MYC ELISA Kits) function that limits c-Myc (show MYC ELISA Kits) activity in transformed cells.
PRH controls the migration of multiple epithelial cell lineages in part at least through the direct transcriptional regulation of Endoglin (show ENG ELISA Kits)
HHEX promotes hepatic specification by repressing EOMES (show EOMES ELISA Kits) expression.
The Hhex evolutionarily conserved non-coding region appears to be a core node for the convergence of the transcription factor network that governs the emergence of Hematopoietic stem cells.
Hhex(-/-) mESCs fail to differentiate from definitive endoderm to hepatic endoderm.
results implicate Hhex in the maintenance of LT-HSCs and in lineage allocation from multipotent progenitors especially in stress hematopoiesis.
Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2 (show LMO2 ELISA Kits)-transgenic mice.
Hhex is a key regulator of early lymphoid development, functioning, at least in part, via regulation of the cell cycle.
Hhex and Cer1 (show CER1 ELISA Kits) are indispensable components of the Sox17 (show SOX17 ELISA Kits) pathway for cardiopoiesis.
Hhex as the first transcriptional regulator specifically required for islet delta cells and suggest compromised paracrine control as a contributor to T2DM
Data suggest that GPC3 (show GPC3 ELISA Kits) down-regulates hepatocyte proliferation by binding to hedgehog (show SHH ELISA Kits) (HH) and down-regulating the HH signaling pathway and binding with CD81 (show CD81 ELISA Kits), thus making it unavailable to bind to Hhex and causing its nuclear translocation.
Hex expression and subcellular localization are associated with chondrocyte maturation
hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors.
Data suggest that zebrafish hhex appears to be activated by Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) in the dorsal yolk syncytial layer, where bozozok acts in a permissive way to limit repression of hhex by Vega1 and Vega2.
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.
Homeobox protein PRH
, hematopoietically-expressed homeobox protein hhex
, homeobox protein hex
, homeodomain transcription factor
, hematopoietically expressed homeobox
, hematopoietically-expressed homeobox protein HHEX
, homeobox protein HEX
, homeobox protein PRH
, homeobox, hematopoietically expressed
, proline-rich homeodomain-containing transcription factor
, hematopoietically expressed homeobox protein
, hematopoietically expressed homeobox, related sequence 2
, hematopoietically-expressed homeobox protein Hhex