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anti-Hemochromatosis Type 2 (Juvenile) (HFE2) Antibodies

The product of HFE2 is involved in iron metabolism. Additionally we are shipping HFE2 Kits (41) and HFE2 Proteins (13) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HFE2 148738 Q6ZVN8
HFE2 310681  
HFE2 69585 Q7TQ32
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Top anti-HFE2 Antibodies at antibodies-online.com

Showing 10 out of 97 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of HFE2 Antibody (C-term) (ABIN653652) in HepG2 cell line lysates (35 µg/lane). HFE2 (arrow) was detected using the purified polyclonal antibody. HFE2 Antibody (C-term) (ABIN653652) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of HFE2 Antibody (Center) (ABIN653653) in mouse heart tissue lysates (35 µg/lane). HFE2 (arrow) was detected using the purified polyclonal antibody. HFE2 Antibody (Center) (ABIN653653) IHC analysis in formalin fixed and paraffin embedded skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow cytometric analysis of HepG2 cells using HFE2 / Hemojuvelin Antibody (C-term) Cat.-No AP52037PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of HFE2 / Hemojuvelin Antibody (C-term) in HepG2 cell line lysates (35ug/lane). HFE2 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded skeletal muscle reacted with HFE2 / Hemojuvelin Antibody (Center) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Western blot analysis of HFE2 / Hemojuvelin Antibody (Center) in mouse heart tissue lysates (35ug/lane). HFE2 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-HFE2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: HT1080 cell lysate WB Suggested Anti-HFE2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: HT1080 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB HFE2 polyclonal antibody (A01), Lot # 060519JCS1 Western Blot analysis of HFE2 expression in U-2 OS . Western Blot detection against Immunogen (35.02 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Anti-HFE2 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN961242 concentration 5 ug/ml. 50 μg Log in to see 8 to 10 Days
$511.50
Details
Human Rabbit APC IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details

HFE2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-HFE2 Antibodies

  1. Human Polyclonal HFE2 Primary Antibody for EIA, FACS - ABIN952726 : Zhang, Yang, Wang, Tsukamoto, Enns: Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression. in The Journal of biological chemistry 2009 (PubMed)
    Show all 3 references for ABIN952726

  2. Human Polyclonal HFE2 Primary Antibody for IHC (p), WB - ABIN952727 : Zhu, Feng, Li, Lu, Elston: Detecting rare variants for complex traits using family and unrelated data. in Genetic epidemiology 2010 (PubMed)
    Show all 3 references for ABIN952727

  3. Human Polyclonal HFE2 Primary Antibody for ELISA, WB - ABIN566853 : Lakhal, Schödel, Townsend, Pugh, Ratcliffe, Mole: Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis. in The Journal of biological chemistry 2011 (PubMed)

More Antibodies against HFE2 Interaction Partners

Human Hemochromatosis Type 2 (Juvenile) (HFE2) interaction partners

  1. HJV levels are low in NAFLD (show TSC2 Antibodies) and even lower in iron overloaded NAFLD (show TSC2 Antibodies).

  2. Data show that transmembrane serine protease (show F2 Antibodies) TMPRSS6 (show TMPRSS6 Antibodies) cleaves both the heterodimeric and the full-length mutant hemojuvelin (m-HJV).

  3. Hereditary haemochromatosis caused by homozygous HJV mutation evolved through paternal disomy.

  4. The study demonstrates that the two upstream open reading frames (with 28 and 19 codons) present in the 5' UTR (show UTS2R Antibodies) of the human HJV mRNA have the ability to significantly decrease translational efficiency under normal conditions.

  5. Case Reports: juvenile hemochromatosis (show HFE Antibodies) associated with simple heterozygosity for novel HJV mutations and unknown genetic factors.

  6. suggesting that the homozygous mutation p.C321X in HJV is causative in the patient with hemochromatosis (show HFE Antibodies)

  7. In dialysis patients, hemojuvelin levels are significantly increased but obesity does not have an additional impact.

  8. Membrane bound hemojuvelin (HJV) is associated with decreasing total kidney iron, secreting hepcidin (show HAMP Antibodies), and promoting the degradation of ferroportin (show SLC40A1 Antibodies) during acute kidney injury, whereas soluble HJV does the opposite.

  9. Data show that Patients with iron-refractory iron-deficiency anemia with a mutation in the TMPRSS6 (show TMPRSS6 Antibodies) gene were found to have lower levels of circulating hemojuvelin than those in healthy patients.

  10. Hemojuvelin and hepcidin (show HAMP Antibodies) affect iron metabolism and are elevated in kidney and heart allograft recipients

Mouse (Murine) Hemochromatosis Type 2 (Juvenile) (HFE2) interaction partners

  1. Single Hjv(-)/(-) and double Hfe (show HFE Antibodies)(-)/(-)Hjv(-)/(-) mice exhibit comparable iron overload. Hfe (show HFE Antibodies) and Hjv regulate hepcidin (show HAMP Antibodies) via the same pathway.

  2. Results show that HFE (show HFE Antibodies) may depend on HJV for hepcidin (show HAMP Antibodies) regulation. Residual hepcidin (show HAMP Antibodies) in the absence of HFE (show HFE Antibodies) suggests either the presence of an unknown regulator synergistic with HJV or that HJV is sufficient to maintain basal levels of hepcidin (show HAMP Antibodies).

  3. Parenchymal hepatic iron overload does not suffice to trigger progression of liver steatosis to steatohepatitis or fibrosis in Hjv knockout C57BL/6 mice.

  4. Hjv is not required for sensing of body iron levels and merely functions as an enhancer for iron signaling to hepcidin (show HAMP Antibodies).

  5. Deletion of Hjv in mice leads to abnormal retinal angiogenesis/vasculogenesis, with proliferation of new, leaky blood vessels in the vitreous.

  6. Loss of matriptase-2 (show TMPRSS6 Antibodies) increases bone morphogenetic protein-dependent signaling, while paradoxically decreasing liver hemojuvelin protein content.

  7. Use of proteomic analysis enables identification of four disulfide linkages in hemojuvelin/repulsive guidance molecule C. This molecule is a single-chain HJV/RGMc isoform.

  8. we conclude that TNF-alpha (show TNF Antibodies) suppresses Hemojuvelin(HJV) transcription possibly via a novel TNFRE within the HJV promoter

  9. high levels of serum s-HJV in CDA I patients, suggesting that it may contribute to iron loading pathology in CDA I and eventually in other anemias with ineffective erythropoiesis.

  10. Hemojuvelin is essential for transferrin (show Tf Antibodies)-dependent and transferrin (show Tf Antibodies)-independent hepcidin (show HAMP Antibodies) expression in conditions of iron overload.

HFE2 Antigen Profile

Protein Summary

The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Gene names and symbols associated with HFE2

  • hemochromatosis type 2 (juvenile) (HFE2) antibody
  • hemochromatosis type 2 (juvenile) (Hfe2) antibody
  • hemochromatosis type 2 (juvenile) (human homolog) (Hfe2) antibody
  • hemojuvelin (LOC100355707) antibody
  • 2310035L15Rik antibody
  • 5230400G09Rik antibody
  • AI414844 antibody
  • AI789733 antibody
  • DKFZp468F2322 antibody
  • DL-M antibody
  • hemojuvelin antibody
  • HFE2 antibody
  • HFE2A antibody
  • HJV antibody
  • JH antibody
  • Rgmc antibody

Protein level used designations for HFE2

hemochromatosis type 2 (juvenile) , RGM domain family member C , haemojuvelin , hemochromatosis type 2 protein , hemojuvelin , repulsive guidance molecule c , hemochromatosis type 2 (juvenile) (human homolog) , hemochromatosis type 2 protein homolog , repulsive guidance molecule C

GENE ID SPECIES
475830 Canis lupus familiaris
698805 Macaca mulatta
743630 Pan troglodytes
746490 Pan troglodytes
100174250 Pongo abelii
100594831 Nomascus leucogenys
148738 Homo sapiens
310681 Rattus norvegicus
100733082 Cavia porcellus
100155778 Sus scrofa
100335368 Bos taurus
101114997 Ovis aries
69585 Mus musculus
100355707 Oryctolagus cuniculus
Selected quality suppliers for anti-HFE2 (HFE2) Antibodies
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