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The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Additionally we are shipping HBd Proteins (17) and HBd Kits (3) and many more products for this protein.
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The expression of the activated delta-globin gene in a beta (show SUCLA2 Antibodies)-thalassemia mice model greatly improves the phenotype, validating the delta-globin chain as a therapeutic target for beta-hemoglobinopathies.
Data indicate that a delta-globin mutation was suspected in both patients.
A functional promoter polymorphism of the delta-globin gene is a specific marker of the Arab-Indian haplotype
This report describes a novel missense mutation in delta-globin (HBD: c.323G>A, Gly > Asp (show ASIP Antibodies)) in an Indian family with heterozygous beta-thalassemia with normal HbA(2 (show HBa2 Antibodies)) levels.
Family study reporting normal Hemoglobin (show HBB Antibodies) A expression in a beta (show SUCLA2 Antibodies)-goblin (show FRMD4B Antibodies) carrier (beta(+) IVSI-5 (G to C) mutation) with microcytosis and hypochromiadue, due to co-inheritance of mutation in the delta-globin gene (delta codon 12 (AAT (show SERPINA1A Antibodies)-->AAA (show APP Antibodies)) HbA2 (show HBa2 Antibodies)-NYU).
Studies present five new hemoglobin (Hb) variants, Hb Canuts, Hb Ambroise Pare, Hb Beaujolais, Hb Monplaisir and Hb(A2)-North Africa.
Data report the study of 23 double heterozygotes for beta- and delta-thalassemia defects or variants. Eight delta-globin and seven beta-globin (show HBB Antibodies) alleles were detected. All the alleles were associated with RFLP haplotype background.
The 5' breakapoint of the (deltabeta)(0) thalassemia deletion in a compound heterozygote was located in the second intron of the delta globin gene.
Hb A2-Monreale [delta146(HC3 (show PSMA2 Antibodies))His-->Arg]is a novel delta chain variant.
The atomic coordinates of the delta-chain of hemoglobin A2 (R2 state) are used to model the structure of hemoglobin homotetramer delta 4, which occurs in rare hemoglobin H disease.
The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia.
, hemoglobin subunit delta
, delta globin
, delta-globin chain
, hemoglobin delta chain
, Hemoglobin delta chain
, Hemoglobin subunit delta
, hemoglobin, beta
, globin, beta I, larval
, hemoglobin beta-1 chain, larval
, hemoglobin larval subunit beta-1