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The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. Additionally we are shipping Hemoglobin Alpha, Adult Chain 1 Proteins (122) and Hemoglobin Alpha, Adult Chain 1 Antibodies (15) and many more products for this protein.
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identify a novel sequence on Hb alpha that is important for Hb alpha/eNOS (show NOS3 ELISA Kits) complex formation and is critical for nitric oxide signaling at myoendothelial junctions
The human locus establishes prominent sites of Polycomb (show CBX2 ELISA Kits) complex recruitment in pluripotent stem cells, whereas the corresponding mouse locus does not.
The objective of this study was to test whether amino acid differences among triplicated alpha-globin paralogs are attributable to a relaxation of purifying selection or to a history of positive selection.
It is suggested that the higher expression of hemoglobin (show HBB ELISA Kits) alpha1 in the brain may be associated with ECM (show MMRN1 ELISA Kits) and could be a source of excess heme, a molecule that is considered to trigger the pathogenesis of cerebral malaria.
These data suggest that CP2b (show CYP27B1 ELISA Kits) potentiate erythroid cell-specific alpha-globin expression by recruiting CP2c into the nucleus.
Seven novel nondeletional alpha-thalassemia mutations localized on the alpha2-globin gene in the heterozygous state were identified
Gene frequency for HBA2 (show HBa2 ELISA Kits):c.301-24delGinsCTCGGCCC carriers among the Chinese population in Guangxi.
Hemoglobin Constant Spring mutation in Southeast Asians with thalassemia.
We report herein for the first time the description of HbA2 (show HBa2 ELISA Kits)' in the Tunisian population.
In maturing RBC (show CACNA1C ELISA Kits) progenitors AHSP (show aHSP ELISA Kits) bind to free alpha-globin (show HBA1 ELISA Kits) chains to increase the HbA (show SCN2A ELISA Kits) production. (Review)
Two mutations detected the -a(3,7) single gene deletion found in 75% of cases and the nongene deletion a2 IVS1 [-5nt (show ACPP ELISA Kits)] in the remaining samples
Copy number variations in alpha-globin (show HBA1 ELISA Kits) 2 gene is associated with increased levels of HbF with beta thalassemia.
Described is a previously unreported HBA2 gene variant predicted to lead to an in-frame deletion of codons 13 and 14 of the a-globin chain.
Hemoglobin A2 variants are associated with beta-thalassemia.
study presents clinical and experimental data for 3 novel HBA2 (show HBa2 ELISA Kits) gene core and proximal promoter mutations; the 3 [HBA2 (show HBa2 ELISA Kits):c.-59C>T] [HBA2 (show HBa2 ELISA Kits):c.-81C>A] and [HBA2 (show HBa2 ELISA Kits):c.-91G>A] promoter mutations were analysed for HBA2 (show HBa2 ELISA Kits) gene transcriptional and translational activities
Data indicate that on incubating hemoglobin with glyoxal for 0-20 days, advanced glycation end products (AGEs) were detected on day 20.
Residues 33-61a of hemoglobin alpha-chain from cattle tick gut (show GUSB ELISA Kits) exhibit nonconventional conformation for an antimicrobial peptide (show cAMP ELISA Kits), bound to sodium dodecyl sulfate micelles. The peptide is able to disrupt the bacterial membrane of Micrococcus luteus A270.
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin\; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1\; some nondeletion alpha thalassemias have also been reported.
alpha 1 globin
, alpha globin 1
, haemaglobin alpha 1
, hemoglobin alpha chain
, hemoglobin subunit alpha
, Hemoglobin alpha chain
, globin, alpha 1
, alpha globin
, alpha-2 globin