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The protein encoded by HS6ST1 is a member of the heparan sulfate biosynthetic enzyme family. Additionally we are shipping Heparan-Sulfate 6-O-Sulfotransferase 1 Kits (16) and Heparan-Sulfate 6-O-Sulfotransferase 1 Antibodies (14) and many more products for this protein.
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Distinct expression patterns of Sulf1 (show SULF1 Proteins) and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development.
both HS6ST-1 and HS6ST-2 (show HS6ST2 Proteins) are involved in 6-O-sulfation of heparin and that the proper packaging and storage of tryptase (show TPSAB1 Proteins)
6OST1 is predominantly transcribed in epithelial and neural-derived tissues during development
Data show that high expression of 6-O-sulfotransferase (6-OST)-1, 2, or 3 resulted in increased 6-O-sulfation of N-sulfated (show SULF1 Proteins) and N-acetylated glucosamine units, and in altered heparan sulfate domain structure.
Hs2st and/or Hs6st1 expression coincides with Slit expression domains at locations where retinal ganglion cell(RGC) axons make navigation errors in Hs2st-/- and Hs6st1-/- mutants, and Hs6st1-/-RGC axons are less sensitive to Slit2 repulsion.
there is a critical role for HS 6-O sulfation by Hs6st1 in postnatal processes
HS6ST-1 and HS6ST-2 (show HS6ST2 Proteins) have roles in regulating the angiogenic program in ovarian cancer cells affecting HB-EGF (show HBEGF Proteins) signaling and subsequent expression of angiogenic cytokines by cancer cells
Hs6st1 and Hs2st (show HS2ST1 Proteins) generate conditions conducive to corpus callosum development.
idiopathic hypogonadotrophic hypogonadism--associated HS6ST1 mutations display reduced activity in vitro and in vivo, suggesting that HS6ST1 and the complex modifications of extracellular sugars are critical for normal development
we have characterized HS6ST-2 (show HS6ST2 Proteins) and HS6ST-1 human isologues, including their chromosomal localizations,HS6STs could also transfer sulphate to N -sulphoglucosamine residues located at the non-reducing terminal of HS with high affinity.
The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene.
, heparan-sulfate 6-O-sulfotransferase 1
, heparan-sulfate 6-sulfotransferase
, Heparan-sulfate 6-O-sulfotransferase 1
, heparan sulfate 6-sulfotransferase