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Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. Additionally we are shipping Heparanase Kits (36) and Heparanase Proteins (29) and many more products for this protein.
Showing 10 out of 193 products:
Human Polyclonal HPSE Primary Antibody for IHC (fro), IHC (p) - ABIN1450178
Vlodavsky, Friedmann, Elkin, Aingorn, Atzmon, Ishai-Michaeli, Bitan, Pappo, Peretz, Michal, Spector, Pecker: Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. in Nature medicine 1999
Show all 8 references for ABIN1450178
Human Polyclonal HPSE Primary Antibody for EIA, IHC (fro) - ABIN1107505
Navarro, Fares, Sanchez, Nadam, Georges, Moulin, Morales, Pequignot, Bezin: Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats. in Journal of neurochemistry 2008
Heparanase up-regulated the expression of the blood coagulation initiator-tissue factor (show F3 Antibodies) (TF) and interacted with the tissue factor pathway inhibitor (TFPI (show TFPI Antibodies)) on the cell surface membrane of endothelial and tumor cells, leading to dissociation of TFPI (show TFPI Antibodies) and resulting in increased cell surface coagulation activity. [review]
Heparanase procoagulant activity predicts post-surgery necrosis.
Suggest heparanase is a promising, novel target for overcoming myeloma resistance to therapy and that targeting heparanase has the potential to prevent relapse in myeloma and possibly other cancers.
expression of BRMS1 (show BRMS1 Antibodies) and/or HPA might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma
in colorectal adenomas, the heparanase-1 does not participate in syndecan-1 (show SDC1 Antibodies) degradation; the heparanase-2 (show HPSE2 Antibodies) does not stimulate syndecan-1 (show SDC1 Antibodies) degradation by the action of heparanase-1, and the heparanase-2 (show HPSE2 Antibodies) may be involved in the modulation of the heparanase-1 activity.
higher heparanase expression in gastric cancer is associated with clinicopathologic features of depth of invasion, lymph node metastasis.
JAK-2 (show JAK2 Antibodies) V617F mutation results in heparanase up-regulation via the erythropoietin receptor (show EPOR Antibodies).
Studies indicate that heparanase (HPSE) has been a potential target of medical treatment.
our results suggest that HPSE contributes to the proliferation and metastasis of Ovarian cancer and HPSE might be a potent molecular target for Ovarian cancer treatment
Heparanase is over expressed in preeclamptic placentas compared to normal healthy controls, suggesting its role in the development of preeclampsia.
heparanase contributes to allergen-induced eosinophil recruitment to the lung.
Unfractionated heparin inhibits heparanase, and reverses the activation of NF-kappaB (show NFKB1 Antibodies) and MAPK P38 (show MAPK1 Antibodies) signaling pathways to attenuate inflammatory responses induced by sepsis. These results suggest that UFH
Results show a critical role for heparanase in regulating the branching and invasive behavior of normal mammary epithelia which could be the result of its mutually reciprocal feedback with MMP-14 (show MMP14 Antibodies).
Data suggest a potential mechanism of diabetic enteropathy, which is depending remarkably on syndecan-1 (Sdc1 (show SDC1 Antibodies)) and -beta-D-glucuronidase (show GUSB Antibodies) heparanase (HPSE).
Findings identify a dual function for HPSE in malignant melanoma with a protumorigenic extracellular activity and a tumor-suppressive nuclear action.
Studies in heparanase-deficient mice established its contributions to autophagy.
Heparanase is suggested to be a prognostic and diagnostic marker for oral premalignant lesions which could have a major impact on future prognosis and diagnosis of SCC (show CYP11A1 Antibodies) of the oral cavity.
Novel function of heparanase guides cancer-promoting action of TAM (show CCNA1 Antibodies) and heparanase expression status may be predictive of treatment potential, targeting TAM (show CCNA1 Antibodies)/IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies).
Under diabetic conditions, latent heparanase, overexpressed by glomerular cells and posttranslationally activated by cathepsin L (show CTSL1 Antibodies) of tubular origin creates chronic inflammatory conditions and fosters macrophage-mediated renal injury.
We found that heparanase induction is associated with decreased levels of CXCL10 (show CXCL10 Antibodies), suggesting that this chemokine (show CCL1 Antibodies) exerts tumor-suppressor properties in myeloma.
during late gestation, the mRNA and HPSE levels were higher in Meishan placentae than Yorkshire pigs
study of tissue expression profiles, polymorphisms of HPSE and HPSE2 (show HPSE2 Antibodies) genes and changes of their mRNA levels in porcine alveolar macrophages (PAMs) induced by PRRSV; upon stimulation in healthy piglets with PRRSV, HPSE mRNA was obviously upregulated, while HPSE2 (show HPSE2 Antibodies) mRNA did not induce a prominent change in PAMs
our results support a critical role for heparanase in the development of vulnerable atherosclerotic plaques
report molecular cloning and characterisation of heparanase mRNA in the porcine placenta throughout gestation.
Suggest that high glucose is a potent stimulator of endothelial heparanase secretion.
Lutropin (show LHB Antibodies) induces a transient increase in HPSE mRNA at specific times after its addition.
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.
, endoglycosidase heparanase