Hepatic Leukemia Factor Proteins (HLF)

HLF encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. Additionally we are shipping HLF Antibodies (43) and HLF Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HLF 29452 Q9JHS1
HLF 13819 P97481
HLF 3131 Q16534
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Top HLF Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 15 to 19 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 2 to 3 Days

HLF Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine)

Human , ,

Top referenced HLF Proteins

  1. Human HLF Protein expressed in Escherichia coli (E. coli) - ABIN667523 : Falvey, Fleury-Olela, Schibler: The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences. in The EMBO journal 1995 (PubMed)
    Show all 2 references for 667523

More Proteins for Hepatic Leukemia Factor (HLF) Interaction Partners

Mouse (Murine) Hepatic Leukemia Factor (HLF) interaction partners

  1. this study shows that HIF-2alpha (show EPAS1 Proteins) acts in resting macrophages as a phagocytosis suppressor implying an important relationship between the levels of HIF-2alpha (show EPAS1 Proteins) and susceptibility to infection

  2. in neurons HIF-1 (show HIF1A Proteins) and HIF-2 have redundant functions for cellular survival under ischemic conditions. By contrast, lack of anti-survival factors in Hif1a (show HIF1A Proteins)/Hif2a (show EPAS1 Proteins)-deficient mice might protect from early acute neuronal cell death and neurological impairment, indicating a benefit of HIF-pathway inhibition in neurons in the very acute phase after ischemic stroke

  3. HIF-2alpha (show EPAS1 Proteins) is a novel regulator of neutrophil recruitment to colon tumors.

  4. AQP1 (show AQP1 Proteins) deficiency delays long-term ischemia-reperfusion resolution, partly through repressing angiogenesis mediated by destabilizing HIF-2alpha (show EPAS1 Proteins).

  5. HIF1alpha (show HIF1A Proteins) and HIF2alpha (show EPAS1 Proteins) are dispensable for muscle stem cell function under normoxia but are required for maintaining satellite cell self-renewal in hypoxic environments.

  6. eIF3e (show EIF3E Proteins) is an angiogenesis suppressor. Silencing of eIF3e (show EIF3E Proteins) promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2alpha activity.

  7. The regulatory connection between HIF-2alpha (show EPAS1 Proteins) and VEGFR-1 (show FLT1 Proteins), VEGFR-2 (show KDR Proteins) and MMP2 (show MMP2 Proteins).

  8. HIF2alpha (show EPAS1 Proteins) is essential for the acute postprandial regulation of hepatic glucagon (show GCG Proteins) signaling.

  9. demonstrate that HIF-2alpha (show EPAS1 Proteins) is clearly implicated in the TSP1 (show GZMA Proteins) pulmonary regulation and provide new insights on its contribution to pulmonary arterial hypertension-driven vascular remodelling and vasoconstriction

  10. Results demonstrate that Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations and that modulation of the pyridoxine pathway can also influence phenotype severity

Human Hepatic Leukemia Factor (HLF) interaction partners

  1. Poly (ADP-ribose) polymerase (show PARP1 Proteins) inhibitors selectively induce cytotoxicity in TCF3 (show TCF3 Proteins)-HLF (show EPAS1 Proteins)-positive leukemic cells.

  2. HLF-mediated miR-132 directly suppresses TTK expression, thus exerting inhibitory effects on cancer cell proliferation, metastasis and radioresistance.

  3. Drug response profiling of matched patient-derived xenografts revealed a distinct profile for TCF3 (show TCF3 Proteins)-HLF (show EPAS1 Proteins) ALL with resistance to conventional chemotherapeutics but sensitivity to glucocorticoids.

  4. ectopic expression of HLF (show EPAS1 Proteins), an established transcription factor that cycles with circadian rhythms, can recapitulate many features associated with circadian-dependent physiological variation.

  5. both Lmo2 (show LMO2 Proteins) and Bcl-2 (show BCL2 Proteins) are required for the action of E2A (show TCF3 Proteins)-HLF (show EPAS1 Proteins) in leukemogenesis

  6. E2A (show TCF3 Proteins)-HLF (show EPAS1 Proteins) promotes cell survival of t(17;19)- acute lymphoblastic leukemia cells by aberrantly up-regulating LMO2 (show LMO2 Proteins) expression

  7. Evidence pertaining to leukemogenesis by the well-characterized oncogenic fusion protein E2A (show TCF3 Proteins)-HLF (show EPAS1 Proteins) is reviewed and its mechanistic implications are considered.

  8. E2A-HLF induces annexin II by substituting for cytokines that activate downstream pathways of Ras

  9. The E2A (show TCF3 Proteins)-HLF (show EPAS1 Proteins)-mediated over-expression of ABCB1 (show ABCB1 Proteins) may play a role in the clinical phenotype of ALLs with a t(17;19), suggesting pharmacologic modulation of ABCB1 (show ABCB1 Proteins) activity as a rational therapeutic strategy for this chemotherapy resistant subtype of ALL.

  10. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: E2A (show TCF3 Proteins)/PBX1 (show PBX1 Proteins) and E2A (show TCF3 Proteins)/HLF (show EPAS1 Proteins).

HLF Protein Profile

Protein Summary

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Gene names and symbols associated with Hepatic Leukemia Factor Proteins (HLF)

  • hepatic leukemia factor (HLF)
  • hepatic leukemia factor (Hlf)
  • hepatic leukemia factor a (hlfa)
  • Hepatic leukemia factor (Bm1_18395)
  • Hepatic leukemia factor (hlf)
  • endothelial PAS domain protein 1 (Epas1)
  • bHLHe73 protein
  • DKFZp469P0721 protein
  • E230015K02Rik protein
  • HIF-2alpha protein
  • HIF2A protein
  • Hlf protein
  • HLF1 protein
  • HRF protein
  • MOP2 protein
  • zgc:153035 protein

Protein level used designations for Hepatic Leukemia Factor Proteins (HLF)

hepatic leukemia factor , hepatic leukemia factor 1 , zhlf1 , Hepatic leukemia factor , EPAS-1 , HIF-2 alpha , HIF-2-alpha , HIF2 alpha , HIF2-alpha , endothelial PAS domain-containing protein 1 , hypoxia inducible factor 2, alpha subunit , hypoxia inducible factor 2a , hypoxia-inducible factor 2 alpha , hypoxia-inducible factor 2-alpha , HIF-1-alpha-like factor , HIF-related factor , HIF1 alpha-like factor , HIF1alpha-like factor , HLF (HIF1alpha-like factor) , Hif like protein , hypoxia inducible transcription factor 2alpha , mHLF

706623 Macaca mulatta
516069 Bos taurus
100192429 Ovis aries
100171535 Pongo abelii
593063 Strongylocentrotus purpuratus
417395 Gallus gallus
455140 Pan troglodytes
768192 Danio rerio
6098588 Brugia malayi
100380463 Salmo salar
29452 Rattus norvegicus
13819 Mus musculus
3131 Homo sapiens
217082 Mus musculus
363667 Rattus norvegicus
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