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The protein encoded by HEPACAM is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. Additionally we are shipping Hepatic and Glial Cell Adhesion Molecule Antibodies (48) and Hepatic and Glial Cell Adhesion Molecule Kits (4) and many more products for this protein.
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HepaCAM proteins were significantly decreased in bladder carcinoma. Low hepaCAM was not statistically associated with clinicopathological characteristics of the patients. HepaCAM overexpression activated caspase 3 (show CASP3 Proteins)/8/9, downregulated poly-ADP ribose polymerase (show PARP1 Proteins) and p-SMAD2 (show SMAD2 Proteins)/3, and decreased apoptosis.
The suppressive roles of HEPACAM in NSCLC.
Due to the ability to reactivate expression of hepaCAM and inhibit growth of bladder cancer cells, AZAC may represent an effective treatment for bladder cancer.
The extracellular domain of GlialCAM is necessary for cell junction targeting and for mediating interactions with itself or with MLC1 and ClC-2 (show CLCN2 Proteins).
HepaCAM may prevent the translocation of PKCepsilon (show PRKCE Proteins) from cytosolic to particulate fractions, resulting in the inhibition of 786-0 cell proliferation.
GlialCAM is able to interact with all CLC (show CLC Proteins) channels tested in this study, targeting them to cell junctions and activating them by stabilizing the open configuration of the common gate
Results allow classifying the effect of HEPACAM gene mutations in different subtypes and authors indicate different cellular mechanisms that lead to megalencephalic leukoencephalopathy pathogenesis.
we demonstrate an evolutionary conserved role for MLC1 in regulating glial surface levels of GLIALCAM, and this interrelationship explains why patients with mutations in either gene (MLC1 or GLIALCAM) share the same clinical phenotype.
High expression of hepaCAM is associated with renal carcinoma.
analysis of mutations in GLIALCAM in patients with megalencephalic leukoencephalopathy with subcortical cysts [case report]
Data indicate that membrane protein MLC1 is crucial for proper localization of adhesion molecule (show NCAM1 Proteins) GlialCAM and chloride channel (show CLCA1 Proteins) ClC-2 (show CLCN2 Proteins), and for changing ClC-2 (show CLCN2 Proteins) currents.
GlialCAM, an immunoglobulin-like cell adhesion molecule (show MCAM Proteins) is expressed in glial cells of the central nervous system.
The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.
hepatocyte cell adhesion molecule
, protein hepaCAM