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The protein encoded by HAVCR2 belongs to the immunoglobulin superfamily, and TIM family of proteins. Additionally we are shipping Hepatitis A Virus Cellular Receptor 2 Antibodies (194) and Hepatitis A Virus Cellular Receptor 2 Kits (6) and many more products for this protein.
Showing 10 out of 34 products:
Human HAVCR2 Protein expressed in HEK-293 Cells - ABIN2181817
Monney, Sabatos, Gaglia, Ryu, Waldner, Chernova, Manning, Greenfield, Coyle, Sobel, Freeman, Kuchroo: Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. in Nature 2002
Show all 5 references for ABIN2181817
Mouse (Murine) HAVCR2 Protein expressed in Human Cells - ABIN2008706
Sabatos, Chakravarti, Cha, Schubart, Sánchez-Fueyo, Zheng, Coyle, Strom, Freeman, Kuchroo: Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. in Nature immunology 2003
Show all 5 references for ABIN2008706
Cynomolgus HAVCR2 Protein expressed in Human Cells - ABIN2010140
Zhu, Anderson, Schubart, Xiong, Imitola, Khoury, Zheng, Strom, Kuchroo: The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. in Nature immunology 2005
Show all 5 references for ABIN2010140
Human HAVCR2 Protein expressed in Human Cells - ABIN2002756
Koguchi, Anderson, Yang, OConnor, Kuchroo, Hafler: Dysregulated T cell expression of TIM3 in multiple sclerosis. in The Journal of experimental medicine 2006
Show all 5 references for ABIN2002756
Human HAVCR2 Protein expressed in Escherichia coli (E. coli) - ABIN1098725
Sánchez-Fueyo, Tian, Picarella, Domenig, Zheng, Sabatos, Manlongat, Bender, Kamradt, Kuchroo, Gutiérrez-Ramos, Coyle, Strom: Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. in Nature immunology 2003
Show all 2 references for ABIN1098725
The Tim-3/Gal-9 (show LGALS9 Proteins) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.
Hepatitis B virus surface antigen stimulation of human, monocyte-derived dendritic cells increases expression of Tim-3.
miR (show MLXIP Proteins)-330-5p has a strong inhibitory effect on TIM-3 expression in acute myeloma leukaemia cell line
Data show there was a negative correlation between soluble T cell immunoglobulin mucin (show SLC13A2 Proteins) molecule 3 (sTim-3) and interferon-gamma (IFN-gamma (show IFNG Proteins)) as well as between IFN-gamma (show IFNG Proteins) and interleukin-4 (IL-4 (show IL4 Proteins)), while sTim-3 and IL-4 (show IL4 Proteins) were positively correlated.
Data suggest that PD-1/PDCD1 (programmed cell death protein 1 (show PDCD1 Proteins)) and Tim-3/HAVCR2 (hepatitis A virus cellular receptor 2) operate within the functional immune-modulatory network to promote Th2-(type-2 helper T cell-)mediated immunity at the maternal-fetal interface.
Reduction of Tim-3(+) Treg cells (Tregs) in osteoarthritis patients resulted in less IL-10 (show IL10 Proteins)-producing Tregs.
findings support the use of Tim-3-Tim-3L blockade together with PD-1 (show PDCD1 Proteins)-PD-L1 (show CD274 Proteins) blockade to reverse tumor-induced T-cell exhaustion/dysfunction in patients with colorectal cancer.
Tim-3 may be used as a novel target for increasing immune responses in RCC (show XRCC1 Proteins) tumor microenvironment.
Diffuse large B-cell lymphoma patients have high expression level of PD-1 (show PDCD1 Proteins) and TIM-3, which are related to DLBCL staging. PD-1 (show PDCD1 Proteins) and TIM-3 expression levels are also related to the efficiency of chemotherapy.
The Gal-9 (show LGALS9 Proteins)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.
These data indicate that Tim-3 expression in NK cells can function as a prognostic biomarker in human lung adenocarcinoma and support that Tim-3 could be a new target for an immunotherapeutic strategy.
in mice, TIM-3 is not essential for development of HDM (show HDAC3 Proteins)-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM (show HDAC3 Proteins)-induced chronic allergic airway inflammation.
Authors found that a CD8 (show CD8A Proteins)(+) T-cell population with age-associated exhaustion was distinguishable by its expression of Tim-3.
TIM4 (show TIMD4 Proteins) binds TIM3 on the surface of polarized Th1 (show HAND1 Proteins) cells to induce Th1 (show HAND1 Proteins) cell apoptosis, which may contribute to the development of Th2-dominant immune disorders.
TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.
Tim-3 acts at a receptor-proximal point to enhance Lyn (show LYN Proteins) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (show FCER1A Proteins) ligation.
Our data indicate that Tim-3 expression on NK cells is regulated by T-bet, and that Tim-3 levels correlate with advanced stages of gastric cancer
TIM-3 plays a role in regulating the uterine natural killer cells and contributes to the maintenance of tolerance at the feto-maternal interface.
TIM-3 is highly expressed in hypoxic brain regions of a mouse cerebral hypoxia-ischaemia (H/I) model. TIM-3 is distinctively upregulated in activated microglia and astrocytes in a HIF-1 (show HIF1A Proteins)-dependent manner.
These data identify an IL-27 (show IL27 Proteins)/NFIL3 (show NFIL3 Proteins) signalling axis as a key regulator of effector T-cell responses via induction of Tim-3, IL-10 (show IL10 Proteins) and T-cell dysfunction.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
hepatitis A virus cellular receptor 2
, T cell immunoglobulin mucin 3
, T cell immunoglobulin mucin-3
, T-cell immunoglobulin and mucin domain-containing protein 3
, T-cell membrane protein 3
, kidney injury molecule-3
, T-cell immunoglobulin and mucin domain containing 3
, hepatitis A virus cellular receptor 2 homolog