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The protein encoded by HAVCR2 belongs to the immunoglobulin superfamily, and TIM family of proteins. Additionally we are shipping Hepatitis A Virus Cellular Receptor 2 Antibodies (195) and Hepatitis A Virus Cellular Receptor 2 Kits (6) and many more products for this protein.
Showing 10 out of 35 products:
Human HAVCR2 Protein expressed in HEK-293 Cells - ABIN2181817
Monney, Sabatos, Gaglia, Ryu, Waldner, Chernova, Manning, Greenfield, Coyle, Sobel, Freeman, Kuchroo: Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. in Nature 2002
Show all 5 references for ABIN2181817
Human HAVCR2 Protein expressed in Human Cells - ABIN2002756
Sabatos, Chakravarti, Cha, Schubart, Sánchez-Fueyo, Zheng, Coyle, Strom, Freeman, Kuchroo: Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. in Nature immunology 2003
Show all 5 references for ABIN2002756
Mouse (Murine) HAVCR2 Protein expressed in Human Cells - ABIN2008706
Zhu, Anderson, Schubart, Xiong, Imitola, Khoury, Zheng, Strom, Kuchroo: The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. in Nature immunology 2005
Show all 5 references for ABIN2008706
Cynomolgus HAVCR2 Protein expressed in Human Cells - ABIN2010140
Koguchi, Anderson, Yang, OConnor, Kuchroo, Hafler: Dysregulated T cell expression of TIM3 in multiple sclerosis. in The Journal of experimental medicine 2006
Show all 5 references for ABIN2010140
Human HAVCR2 Protein expressed in Escherichia coli (E. coli) - ABIN1098725
Sánchez-Fueyo, Tian, Picarella, Domenig, Zheng, Sabatos, Manlongat, Bender, Kamradt, Kuchroo, Gutiérrez-Ramos, Coyle, Strom: Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. in Nature immunology 2003
Show all 2 references for ABIN1098725
The Tim-3/Gal-9 (show LGALS9 Proteins) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.
The results of our study showed that there is no significant association between TIM-1 (show ARHGEF5 Proteins) 5383-5397ins/del and Multiple sclerosis (MS) (P = 0.38); however, the frequency of CT genotype of TIM-3 -1541C>T in patient group was significantly higher than the control group, and there was a significant association between CT genotype and MS
this study shoes that Tim-3 level is significantly upregulated in monocytes from gastric cancer patients compared with those from healthy controls
these results suggest that TIM3 is a novel therapeutic target and prognostic biomarker for esophageal squamous cell carcinoma (ESCC) and promotes metastasis of ESCC by inducing epithelial-mesenchymal transition via, at least partially, the Akt (show AKT1 Proteins)/GSK-3beta/Snail (show SNAI1 Proteins) signaling pathway.
Tim-3 facilitates osteosarcoma proliferation and metastasis through the NF-kappaB (show NFKB1 Proteins) pathway and epithelial-mesenchymal transition.
Studied the associations of T-cell immunoglobulin and mucin (show SLC13A2 Proteins) domain-3 (Tim-3) polymorphisms and the alternate reading frame protein (F protein (show HPD Proteins)) with the outcomes of HCV infection; findings suggest that the rs12186731 CT and rs13170556 TC/CC genotypes of Tim-3 provide potential protective effects with the F protein (show HPD Proteins) in the outcomes of HCV infection and that these effects are related to sex and age.
this study shows that the levels of expression of TIM-3 on CD4 (show CD4 Proteins)+ T cells, CD8 (show CD8A Proteins)+ T cells, CD56 (show NCAM1 Proteins)+ T cells and in serum in patients with systemic lupus erythematosus are significantly higher than those of healthy controls
ovarian tumor-infiltrating Treg cells were more immunosuppressive than their peripheral blood counterparts in a TIM3-dependent fashion.
T cell immunoglobulin and mucin (show SLC13A2 Proteins) domain-containing molecule 3 might participate in the progression of type 2 diabetes by its negative regulation on immune cells, and Tim-3 on CD14 (show NDUFA2 Proteins)(+) monocytes serves as a novel biological marker for diabetes duration in type 2 diabetes patients.
Increased Tim3 expression is associated with renal cell carcinoma (show MOK Proteins).
Hepatitis B virus surface antigen stimulation of human, monocyte-derived dendritic cells increases expression of Tim-3.
Methylation level of the TIM-3 promoter gradually decreased after each round of T-cell polarization, and this decrease was inversely correlated with TIM-3 expression.
in mice, TIM-3 is not essential for development of HDM (show HDAC3 Proteins)-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM (show HDAC3 Proteins)-induced chronic allergic airway inflammation.
Authors found that a CD8 (show CD8A Proteins)(+) T-cell population with age-associated exhaustion was distinguishable by its expression of Tim-3.
TIM4 (show TIMD4 Proteins) binds TIM3 on the surface of polarized Th1 (show HAND1 Proteins) cells to induce Th1 (show HAND1 Proteins) cell apoptosis, which may contribute to the development of Th2-dominant immune disorders.
The Gal-9 (show LGALS9 Proteins)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.
TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.
Tim-3 acts at a receptor-proximal point to enhance Lyn (show LYN Proteins) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (show FCER1A Proteins) ligation.
Our data indicate that Tim-3 expression on NK cells is regulated by T-bet, and that Tim-3 levels correlate with advanced stages of gastric cancer
TIM-3 plays a role in regulating the uterine natural killer cells and contributes to the maintenance of tolerance at the feto-maternal interface.
TIM-3 is highly expressed in hypoxic brain regions of a mouse cerebral hypoxia-ischaemia (H/I) model. TIM-3 is distinctively upregulated in activated microglia and astrocytes in a HIF-1 (show HIF1A Proteins)-dependent manner.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
hepatitis A virus cellular receptor 2
, T cell immunoglobulin mucin 3
, T cell immunoglobulin mucin-3
, T-cell immunoglobulin and mucin domain-containing protein 3
, T-cell membrane protein 3
, kidney injury molecule-3
, T-cell immunoglobulin and mucin domain containing 3
, hepatitis A virus cellular receptor 2 homolog