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Hepatitis A Virus Cellular Receptor 2 Proteins (HAVCR2)

The protein encoded by HAVCR2 belongs to the immunoglobulin superfamily, and TIM family of proteins. Additionally we are shipping Hepatitis A Virus Cellular Receptor 2 Antibodies (194) and Hepatitis A Virus Cellular Receptor 2 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HAVCR2 84868 Q8TDQ0
HAVCR2 171285 Q8VIM0
HAVCR2 363578  
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Top Hepatitis A Virus Cellular Receptor 2 Proteins at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$319.00
Details
HOST_Human Cells Human His tag,Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Cynomolgus Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_HEK-293 Cells Human Fc Tag 100 μg Log in to see 2 to 3 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details

HAVCR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
, , , , , ,
Mouse (Murine) , , , ,
, ,
Rat (Rattus)

Top referenced Hepatitis A Virus Cellular Receptor 2 Proteins

  1. Human HAVCR2 Protein expressed in HEK-293 Cells - ABIN2181817 : Monney, Sabatos, Gaglia, Ryu, Waldner, Chernova, Manning, Greenfield, Coyle, Sobel, Freeman, Kuchroo: Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. in Nature 2002 (PubMed)
    Show all 5 references for ABIN2181817

  2. Mouse (Murine) HAVCR2 Protein expressed in Human Cells - ABIN2008706 : Sabatos, Chakravarti, Cha, Schubart, Sánchez-Fueyo, Zheng, Coyle, Strom, Freeman, Kuchroo: Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. in Nature immunology 2003 (PubMed)
    Show all 5 references for ABIN2008706

  3. Cynomolgus HAVCR2 Protein expressed in Human Cells - ABIN2010140 : Zhu, Anderson, Schubart, Xiong, Imitola, Khoury, Zheng, Strom, Kuchroo: The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. in Nature immunology 2005 (PubMed)
    Show all 5 references for ABIN2010140

  4. Human HAVCR2 Protein expressed in Human Cells - ABIN2002756 : Koguchi, Anderson, Yang, OConnor, Kuchroo, Hafler: Dysregulated T cell expression of TIM3 in multiple sclerosis. in The Journal of experimental medicine 2006 (PubMed)
    Show all 5 references for ABIN2002756

  5. Human HAVCR2 Protein expressed in Escherichia coli (E. coli) - ABIN1098725 : Sánchez-Fueyo, Tian, Picarella, Domenig, Zheng, Sabatos, Manlongat, Bender, Kamradt, Kuchroo, Gutiérrez-Ramos, Coyle, Strom: Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. in Nature immunology 2003 (PubMed)
    Show all 2 references for ABIN1098725

More Proteins for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Interaction Partners

Cow (Bovine) Hepatitis A Virus Cellular Receptor 2 (HAVCR2) interaction partners

  1. The Tim-3/Gal-9 (show LGALS9 Proteins) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.

Human Hepatitis A Virus Cellular Receptor 2 (HAVCR2) interaction partners

  1. Hepatitis B virus surface antigen stimulation of human, monocyte-derived dendritic cells increases expression of Tim-3.

  2. miR (show MLXIP Proteins)-330-5p has a strong inhibitory effect on TIM-3 expression in acute myeloma leukaemia cell line

  3. Data show there was a negative correlation between soluble T cell immunoglobulin mucin (show SLC13A2 Proteins) molecule 3 (sTim-3) and interferon-gamma (IFN-gamma (show IFNG Proteins)) as well as between IFN-gamma (show IFNG Proteins) and interleukin-4 (IL-4 (show IL4 Proteins)), while sTim-3 and IL-4 (show IL4 Proteins) were positively correlated.

  4. Data suggest that PD-1/PDCD1 (programmed cell death protein 1 (show PDCD1 Proteins)) and Tim-3/HAVCR2 (hepatitis A virus cellular receptor 2) operate within the functional immune-modulatory network to promote Th2-(type-2 helper T cell-)mediated immunity at the maternal-fetal interface.

  5. Reduction of Tim-3(+) Treg cells (Tregs) in osteoarthritis patients resulted in less IL-10 (show IL10 Proteins)-producing Tregs.

  6. findings support the use of Tim-3-Tim-3L blockade together with PD-1 (show PDCD1 Proteins)-PD-L1 (show CD274 Proteins) blockade to reverse tumor-induced T-cell exhaustion/dysfunction in patients with colorectal cancer.

  7. Tim-3 may be used as a novel target for increasing immune responses in RCC (show XRCC1 Proteins) tumor microenvironment.

  8. Diffuse large B-cell lymphoma patients have high expression level of PD-1 (show PDCD1 Proteins) and TIM-3, which are related to DLBCL staging. PD-1 (show PDCD1 Proteins) and TIM-3 expression levels are also related to the efficiency of chemotherapy.

  9. The Gal-9 (show LGALS9 Proteins)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.

  10. These data indicate that Tim-3 expression in NK cells can function as a prognostic biomarker in human lung adenocarcinoma and support that Tim-3 could be a new target for an immunotherapeutic strategy.

Mouse (Murine) Hepatitis A Virus Cellular Receptor 2 (HAVCR2) interaction partners

  1. in mice, TIM-3 is not essential for development of HDM (show HDAC3 Proteins)-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM (show HDAC3 Proteins)-induced chronic allergic airway inflammation.

  2. Authors found that a CD8 (show CD8A Proteins)(+) T-cell population with age-associated exhaustion was distinguishable by its expression of Tim-3.

  3. TIM4 (show TIMD4 Proteins) binds TIM3 on the surface of polarized Th1 (show HAND1 Proteins) cells to induce Th1 (show HAND1 Proteins) cell apoptosis, which may contribute to the development of Th2-dominant immune disorders.

  4. The Gal-9 (show LGALS9 Proteins)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.

  5. TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.

  6. Tim-3 acts at a receptor-proximal point to enhance Lyn (show LYN Proteins) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (show FCER1A Proteins) ligation.

  7. Our data indicate that Tim-3 expression on NK cells is regulated by T-bet, and that Tim-3 levels correlate with advanced stages of gastric cancer

  8. TIM-3 plays a role in regulating the uterine natural killer cells and contributes to the maintenance of tolerance at the feto-maternal interface.

  9. TIM-3 is highly expressed in hypoxic brain regions of a mouse cerebral hypoxia-ischaemia (H/I) model. TIM-3 is distinctively upregulated in activated microglia and astrocytes in a HIF-1 (show HIF1A Proteins)-dependent manner.

  10. These data identify an IL-27 (show IL27 Proteins)/NFIL3 (show NFIL3 Proteins) signalling axis as a key regulator of effector T-cell responses via induction of Tim-3, IL-10 (show IL10 Proteins) and T-cell dysfunction.

Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.

Gene names and symbols associated with HAVCR2

  • hepatitis A virus cellular receptor 2 (HAVCR2)
  • hepatitis A virus cellular receptor 2 (Havcr2)
  • HAVcr-2 protein
  • HAVCR2 protein
  • KIM-3 protein
  • MGC140131 protein
  • TIM-3 protein
  • tim3 protein
  • TIMD-3 protein
  • Timd3 protein

Protein level used designations for HAVCR2

hepatitis A virus cellular receptor 2 , T cell immunoglobulin mucin 3 , T cell immunoglobulin mucin-3 , T-cell immunoglobulin and mucin domain-containing protein 3 , T-cell membrane protein 3 , kidney injury molecule-3 , HAVcr-2 , T-cell immunoglobulin and mucin domain containing 3 , TIMD-3 , hepatitis A virus cellular receptor 2 homolog , TIM-3

GENE ID SPECIES
462219 Pan troglodytes
768047 Bos taurus
84868 Homo sapiens
171285 Mus musculus
363578 Rattus norvegicus
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