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Hepatitis A Virus Cellular Receptor 2 Proteins (HAVCR2)

The protein encoded by HAVCR2 belongs to the immunoglobulin superfamily, and TIM family of proteins. Additionally we are shipping Hepatitis A Virus Cellular Receptor 2 Antibodies (191) and Hepatitis A Virus Cellular Receptor 2 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HAVCR2 84868 Q8TDQ0
HAVCR2 171285 Q8VIM0
HAVCR2 363578  
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Top Hepatitis A Virus Cellular Receptor 2 Proteins at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$319.00
Details
HOST_Human Cells Human His tag,Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Cynomolgus Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_HEK-293 Cells Human Fc Tag 100 μg Log in to see 2 to 3 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details

HAVCR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
, , , , ,
Mouse (Murine) , , ,
, ,
Rat (Rattus)

Top referenced Hepatitis A Virus Cellular Receptor 2 Proteins

  1. Human HAVCR2 Protein expressed in HEK-293 Cells - ABIN2181817 : Monney, Sabatos, Gaglia, Ryu, Waldner, Chernova, Manning, Greenfield, Coyle, Sobel, Freeman, Kuchroo: Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. in Nature 2002 (PubMed)
    Show all 5 references for ABIN2181817

  2. Cynomolgus HAVCR2 Protein expressed in Human Cells - ABIN2010140 : Sabatos, Chakravarti, Cha, Schubart, Sánchez-Fueyo, Zheng, Coyle, Strom, Freeman, Kuchroo: Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. in Nature immunology 2003 (PubMed)
    Show all 5 references for ABIN2010140

  3. Mouse (Murine) HAVCR2 Protein expressed in Human Cells - ABIN2008706 : Zhu, Anderson, Schubart, Xiong, Imitola, Khoury, Zheng, Strom, Kuchroo: The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. in Nature immunology 2005 (PubMed)
    Show all 5 references for ABIN2008706

  4. Human HAVCR2 Protein expressed in Human Cells - ABIN2002756 : Koguchi, Anderson, Yang, OConnor, Kuchroo, Hafler: Dysregulated T cell expression of TIM3 in multiple sclerosis. in The Journal of experimental medicine 2006 (PubMed)
    Show all 5 references for ABIN2002756

  5. Human HAVCR2 Protein expressed in Escherichia coli (E. coli) - ABIN1098725 : Sánchez-Fueyo, Tian, Picarella, Domenig, Zheng, Sabatos, Manlongat, Bender, Kamradt, Kuchroo, Gutiérrez-Ramos, Coyle, Strom: Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. in Nature immunology 2003 (PubMed)
    Show all 2 references for ABIN1098725

More Proteins for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Interaction Partners

Cow (Bovine) Hepatitis A Virus Cellular Receptor 2 (HAVCR2) interaction partners

  1. The Tim-3/Gal-9 (show LGALS9 Proteins) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.

Human Hepatitis A Virus Cellular Receptor 2 (HAVCR2) interaction partners

  1. The Gal-9 (show LGALS9 Proteins)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.

  2. These data indicate that Tim-3 expression in NK cells can function as a prognostic biomarker in human lung adenocarcinoma and support that Tim-3 could be a new target for an immunotherapeutic strategy.

  3. Tim-3 in primary leukocytes, both healthy and malignant AML cells, displays moderate properties of an inflammatory receptor with additional growth factor (mTOR activation) and pro-angiogenic (VEGF release) activities

  4. Tim-3 played an important role in the development and progression of gastric cancer, and it could be used as an independent prognostic factor for gastric cancer patients.

  5. an abnormal Tim-3/Gal-9 (show LGALS9 Proteins) pathway was able to facilitate the development of preeclampsia.

  6. sTim-3 was involved in the development of sepsis. The homeostasis-promoting role of the Tim-3 on the monocytes was disrupted, while the inhibitory role of sTim-3 emerged during sepsis-induced immunosuppression.

  7. decreased serum TIM-1 (show ARHGEF5 Proteins) and TIM-3 levels and association of TIM-3 with nephritis suggest their possible role in the development and pathogenesis of systemic lupus erythematosus.

  8. Results indicate that upregulation of the inhibitory receptor Tim-3 may restrict T cell responses in CRC (show CALR Proteins) patients.

  9. TIM-3 is a negative regulator of TCR-function by attenuating activation signals mediated by CD3 (show CD3 Proteins)/CD28 (show CD28 Proteins) co-stimulation.

  10. Tim-3 might participate in the tumorgenesis of colon cancer and Tim-3 expression might be a potential independent prognostic factor for patients with colorectal cancer.

Mouse (Murine) Hepatitis A Virus Cellular Receptor 2 (HAVCR2) interaction partners

  1. The Gal-9 (show LGALS9 Proteins)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.

  2. TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.

  3. Tim-3 acts at a receptor-proximal point to enhance Lyn (show LYN Proteins) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (show FCER1A Proteins) ligation.

  4. Our data indicate that Tim-3 expression on NK cells is regulated by T-bet, and that Tim-3 levels correlate with advanced stages of gastric cancer

  5. TIM-3 plays a role in regulating the uterine natural killer cells and contributes to the maintenance of tolerance at the feto-maternal interface.

  6. TIM-3 is highly expressed in hypoxic brain regions of a mouse cerebral hypoxia-ischaemia (H/I) model. TIM-3 is distinctively upregulated in activated microglia and astrocytes in a HIF-1 (show HIF1A Proteins)-dependent manner.

  7. These data identify an IL-27 (show IL27 Proteins)/NFIL3 (show NFIL3 Proteins) signalling axis as a key regulator of effector T-cell responses via induction of Tim-3, IL-10 (show IL10 Proteins) and T-cell dysfunction.

  8. CD4 (show CD4 Proteins)+ T cell-dependent "negative" TIM-3 costimulation is essential for hepatic homeostasis and resistance against IR stress in OLTs

  9. In DSS (show PMP22 Proteins) colitis, Tim-3 inhibited the polarization of pathogenic pro-inflammatory M1 macrophages, while Tim-3 downregulation or blockade resulted in an increased M1 response. Tim-3 effect on macrophage response may be TLR4 (show TLR4 Proteins) dependent.

  10. These data suggest that Tim-3 and IFN-gamma (show IFNG Proteins) may play a regulatory role in T. gondii-infected pregnant mouse model.

Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.

Gene names and symbols associated with HAVCR2

  • hepatitis A virus cellular receptor 2 (HAVCR2)
  • hepatitis A virus cellular receptor 2 (Havcr2)
  • HAVcr-2 protein
  • HAVCR2 protein
  • KIM-3 protein
  • MGC140131 protein
  • TIM-3 protein
  • tim3 protein
  • TIMD-3 protein
  • Timd3 protein

Protein level used designations for HAVCR2

hepatitis A virus cellular receptor 2 , T cell immunoglobulin mucin 3 , T cell immunoglobulin mucin-3 , T-cell immunoglobulin and mucin domain-containing protein 3 , T-cell membrane protein 3 , kidney injury molecule-3 , HAVcr-2 , T-cell immunoglobulin and mucin domain containing 3 , TIMD-3 , hepatitis A virus cellular receptor 2 homolog , TIM-3

GENE ID SPECIES
462219 Pan troglodytes
768047 Bos taurus
84868 Homo sapiens
171285 Mus musculus
363578 Rattus norvegicus
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