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anti-Hepsin (HPN) Antibodies

HPN encodes a type II transmembrane serine protease that may function in diverse processes, including regulation of cell growth. Additionally we are shipping Hepsin Proteins (7) and Hepsin Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HPN 3249 P05981
HPN 15451 O35453
HPN 29135 Q05511
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Top anti-Hepsin Antibodies at antibodies-online.com

Showing 10 out of 45 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Anti-Hepsin antibody, Western blotting Lane 1: 293T Cell Lysate Lane 2... 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-HPN / Hepsin antibody IHC staining of human liver. Immunohistoche... 100 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat kidney labeled with Rabbit An... Formalin-fixed and paraffin embedded human liver carcinoma labeled wit... 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated WB   100 μg Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit Un-conjugated IHC (p), WB 100 μL Log in to see 11 to 13 Days
$541.80
Details
Human Rabbit Biotin IHC (p), WB   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

HPN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
, , ,
Mouse (Murine) , , , ,

Rat (Rattus) , , ,

More Antibodies against Hepsin Interaction Partners

Zebrafish Hepsin (HPN) interaction partners

  1. Hepsin plays a physiologically important role in factor VII (show TH Antibodies) activation and hemostasis in zebrafish.

Human Hepsin (HPN) interaction partners

  1. The findings suggest that the oncogenic activity of hepsin arises not only from elevated expression level but also from depletion of HAI-1 (show SPINT1 Antibodies), events which together trigger gain-of-function activity impacting HGF (show HGF Antibodies)/MET signalling and epithelial cohesion

  2. The Hepsin pathway acts in concert with Wnt (show WNT2 Antibodies) pathway to promote prostate cancer progression.

  3. Low expression levels of hepsin and TMPRSS3 (show TMPRSS4 Antibodies) are associated with poor breast cancer survival

  4. Hepsin suppressed CDK11p58 internal ribosome entry site activity in prostate cancer cells by modulating UNR (show P2RY4 Antibodies) expression and eIF-2alpha (show EIF2S1 Antibodies) phosphorylation.

  5. The results of this study suggest that, in Korean men, some polymorphisms in the HPN gene might be associated with the risk of developing prostate cancer.

  6. hepsin expression is frequently up-regulated in breast cancer tissues, which is associated with tumor growth and progression

  7. These findings suggest that the MSP (show MSMB Antibodies)/RON (show MST1R Antibodies) signaling pathway may be regulated by hepsin in tissue homeostasis and in disease pathologies, such as in cancer and immune disorders.

  8. Elevated levels of hepsin interfere with cell adhesion and viability in the background of prostate cancer as well as other tissue types, the details of which depend on the microenvironment provided.

  9. Hepsin activity was inhibited by anthralin and increased by resveratrol.

  10. Germline genetic variation of HPN does not seem to contribute to risk of prostate cancer or prognosis.

Mouse (Murine) Hepsin (HPN) interaction partners

  1. crystal structure of human hepsin, confirming cleavage and association of the two chains

  2. Hepsin cooperates with MYC (show MYC Antibodies) in the progression of adenocarcinoma in a prostate cancer mouse model.

  3. Results suggest that upregulation of the cell surface serine protease hepsin in a primary tumor promotes cancer progression and metastasis.

  4. the ability of hepsin to efficiently activate pro-uPA (show PLAU Antibodies) suggests that it may initiate plasmin (show PLG Antibodies)-mediated proteolytic pathways at the tumor/stroma interface that lead to basement membrane disruption and tumor progression

  5. Hearing impairment present in hepsin/Tmprss1-null mice is characterized by a combination of various structural, cellular, and molecular abnormalities that are likely to affect different cochlear processes.

  6. The ability of ectopic hepsin to induce tumor growth in mice is abrogated by the mutation of 3 critical residues in the catalytic domain, thus implicating the enzymatic activity of hepsin in promoting tumor progression.

  7. Ln-332 may be one mechanism by which hepsin promotes prostate tumor progression and metastasis, possibly by up-regulating prostate cancer cell motility.

Hepsin (HPN) Antigen Profile

Protein Summary

This gene encodes a type II transmembrane serine protease that may function in diverse processes, including regulation of cell growth. Deficiency in this gene results in hearing loss. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with anti-Hepsin (HPN) Antibodies

  • hepsin (HPN) antibody
  • si:dkey-33i11.3 (si:dkey-33i11.3) antibody
  • hepsin (LOC100345382) antibody
  • hepsin (Hpn) antibody
  • Hlb320 antibody
  • TMPRSS1 antibody

Protein level used designations for anti-Hepsin (HPN) Antibodies

hepsin (transmembrane protease, serine 1) , serine protease hepsin , Serine protease hepsin , transmembrane protease serine 1 , transmembrane protease, serine 1 , hepsin

GENE ID SPECIES
455944 Pan troglodytes
569259 Danio rerio
707242 Macaca mulatta
484583 Canis lupus familiaris
100173788 Pongo abelii
100345382 Oryctolagus cuniculus
100591395 Nomascus leucogenys
3249 Homo sapiens
15451 Mus musculus
29135 Rattus norvegicus
508148 Bos taurus
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