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Hepsin Proteins (HPN)

HPN encodes a type II transmembrane serine protease that may function in diverse processes, including regulation of cell growth. Additionally we are shipping Hepsin Antibodies (47) and Hepsin Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HPN 3249 P05981
HPN 15451 O35453
Rat HPN HPN 29135 Q05511
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Top Hepsin Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

HPN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Hepsin (HPN) Interaction Partners

Zebrafish Hepsin (HPN) interaction partners

  1. Hepsin plays a physiologically important role in factor VII (show TH Proteins) activation and hemostasis in zebrafish.

Human Hepsin (HPN) interaction partners

  1. These data demonstrate that the membrane-bound serine protease hepsin is the enzyme responsible for the physiological cleavage of uromodulin (show UMOD Proteins).

  2. The findings suggest that the oncogenic activity of hepsin arises not only from elevated expression level but also from depletion of HAI-1 (show SPINT1 Proteins), events which together trigger gain-of-function activity impacting HGF (show HGF Proteins)/MET signalling and epithelial cohesion

  3. The Hepsin pathway acts in concert with Wnt (show WNT2 Proteins) pathway to promote prostate cancer progression.

  4. Low expression levels of hepsin and TMPRSS3 (show TMPRSS4 Proteins) are associated with poor breast cancer survival

  5. Hepsin suppressed CDK11p58 internal ribosome entry site activity in prostate cancer cells by modulating UNR (show P2RY4 Proteins) expression and eIF-2alpha (show EIF2S1 Proteins) phosphorylation.

  6. The results of this study suggest that, in Korean men, some polymorphisms in the HPN gene might be associated with the risk of developing prostate cancer.

  7. hepsin expression is frequently up-regulated in breast cancer tissues, which is associated with tumor growth and progression

  8. These findings suggest that the MSP (show MSMB Proteins)/RON (show MST1R Proteins) signaling pathway may be regulated by hepsin in tissue homeostasis and in disease pathologies, such as in cancer and immune disorders.

  9. Elevated levels of hepsin interfere with cell adhesion and viability in the background of prostate cancer as well as other tissue types, the details of which depend on the microenvironment provided.

  10. Hepsin activity was inhibited by anthralin and increased by resveratrol.

Mouse (Murine) Hepsin (HPN) interaction partners

  1. crystal structure of human hepsin, confirming cleavage and association of the two chains

  2. Hepsin cooperates with MYC (show MYC Proteins) in the progression of adenocarcinoma in a prostate cancer mouse model.

  3. Results suggest that upregulation of the cell surface serine protease hepsin in a primary tumor promotes cancer progression and metastasis.

  4. the ability of hepsin to efficiently activate pro-uPA (show PLAU Proteins) suggests that it may initiate plasmin (show PLG Proteins)-mediated proteolytic pathways at the tumor/stroma interface that lead to basement membrane disruption and tumor progression

  5. Hearing impairment present in hepsin/Tmprss1-null mice is characterized by a combination of various structural, cellular, and molecular abnormalities that are likely to affect different cochlear processes.

  6. The ability of ectopic hepsin to induce tumor growth in mice is abrogated by the mutation of 3 critical residues in the catalytic domain, thus implicating the enzymatic activity of hepsin in promoting tumor progression.

  7. Ln-332 may be one mechanism by which hepsin promotes prostate tumor progression and metastasis, possibly by up-regulating prostate cancer cell motility.

Hepsin (HPN) Protein Profile

Protein Summary

This gene encodes a type II transmembrane serine protease that may function in diverse processes, including regulation of cell growth. Deficiency in this gene results in hearing loss. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with Hepsin Proteins (HPN)

  • hepsin (HPN)
  • si:dkey-33i11.3 (si:dkey-33i11.3)
  • hepsin (LOC100345382)
  • hepsin (Hpn)
  • Hlb320 protein
  • TMPRSS1 protein

Protein level used designations for Hepsin Proteins (HPN)

hepsin (transmembrane protease, serine 1) , serine protease hepsin , Serine protease hepsin , transmembrane protease serine 1 , transmembrane protease, serine 1 , hepsin

GENE ID SPECIES
455944 Pan troglodytes
569259 Danio rerio
707242 Macaca mulatta
484583 Canis lupus familiaris
100173788 Pongo abelii
100345382 Oryctolagus cuniculus
100591395 Nomascus leucogenys
3249 Homo sapiens
15451 Mus musculus
29135 Rattus norvegicus
508148 Bos taurus
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