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Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Additionally we are shipping HNRNPL Antibodies (70) and HNRNPL Kits (12) and many more products for this protein.
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hnRNP L controls inclusion of a broad spectrum of alternative cassette exons in T cells.
The study presents the structural characterization of the RNA recognition motif domains of hnRNP-L and demonstrate their function in repressing exon 4 of SLC2A2 (show SLC2A2 Proteins).
HnRNP C (show HNRNPC Proteins), YB-1 (show YBX1 Proteins) and hnRNP L coordinately enhance skipping of human MUSK (show MUSK Proteins) exon 10 to generate a Wnt (show WNT2 Proteins)-insensitive MuSK (show MUSK Proteins) isoform.
Data suggest that incorporation of 3(S)-methyl-beta-alanine into a short alpha-helical region of nucleic acid binding domain of hnRNP (show HNRNPC Proteins) LL significantly stabilizes helix without affecting its DNA binding properties.
Our results reveal that hnRNP L is a new regulator for CD44 (show CD44 Proteins) V10 exon splicing.
hnRNP K (show HNRNPK Proteins) and hnRNP L may serve as A1CF (show A1CF Proteins)-like cofactors in AID-mediated class switch recombination and somatic hypermutation
Results show that HNRNPL represses splicing when bound to intronic regions upstream of alternative exons, and in contrast, activates splicing when bound to the downstream intron.
hnRNP L is a potential biomarker for the diagnosis of HBV-HCC (show FAM126A Proteins) and show that hnRNP L contributes to HCC (show FAM126A Proteins) progression.
HnRNP L and hnRNP (show HNRNPC Proteins) LL antagonistically modulate PTB (show PTBP1 Proteins)-mediated splicing suppression of CHRNA1 (show CHRNA1 Proteins) pre-mRNA.
THRIL has a role in regulating TNFalpha (show TNF Proteins) expression through its interaction with hnRNPL
Hnrnpl binds to p53 (show TP53 Proteins) and inhibits its activation in mouse embryonic stem cells.
Aire (show AIRE Proteins)-containing complexes include 7SK RNA, the latter interaction disrupted by HNRNPL knockdown, suggesting that HNRNPL may partake in delivering inactive P-TEFb (show CCNT1 Proteins) to Aire (show AIRE Proteins)
Results identify a cancer-specific mechanism of hnRNP L phosphorylation and subsequent lowering of the caspase (show CASP3 Proteins)-9a/9b ratio, which is required for the tumorigenic capacity of non-small cell lung cancer cells.
identified hnRNP L as a novel Sam68 (show KHDRBS1 Proteins)-interacting protein partner.
Inflammation modulates the interaction of hnRNP I (show PTBP1 Proteins) and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase (show NOS2 Proteins) mRNA
decreased surface alpha2beta1 results from decreased Itga2 (show ITGA2 Proteins) pre-mRNA splicing regulated by hnRNP L and depends on CA repeat length at a specific site in intron 1
iNOS mRNA degradation is promoted upon binding of hnRNPI and hnRNPL to a destabilizing region within its 3'-UTR
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.
RNA-binding protein XlhnRNPL
, heterogeneous nuclear ribonucleoprotein L
, Heterogeneous nuclear ribonucleoprotein L
, hnRNP L
, heterogenous nuclear ribonucleoprotein L