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Heterogeneous Nuclear Ribonucleoprotein L-Like Proteins (HNRPLL)

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. Additionally we are shipping Heterogeneous Nuclear Ribonucleoprotein L-Like Antibodies (43) and Heterogeneous Nuclear Ribonucleoprotein L-Like Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HNRPLL 92906 Q8WVV9
HNRPLL 72692 Q921F4
Rat HNRPLL HNRPLL 313842  
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Top Heterogeneous Nuclear Ribonucleoprotein L-Like Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

HNRPLL Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Heterogeneous Nuclear Ribonucleoprotein L-Like (HNRPLL) Interaction Partners

Human Heterogeneous Nuclear Ribonucleoprotein L-Like (HNRPLL) interaction partners

  1. Loss-of-function mutati (show PTPRC Proteins)on of hnRNPLL disrupts peripheral T cell accumulation even in the absence of CD45 protein, indicating that hnRNPLL acts through an independent mechanism to promote (show PTPRC Proteins)peripheral T cell longevity.

  2. Participation of SRRF (Stromal RNA Regulating Factor) isoforms in post-transcriptional events in bone marrow stromal cells; an important role in regulation of the RNA expression that directs the bone marrow stromal cells differentiation pathway

  3. identification of heterogeneous ribonucleoprotein L-like (hnRNPLL) as a critical inducible regulator of CD45 (show PTPRC Proteins) alternative splicing

  4. These data establish that hnRNP (show HNRNPC Proteins) LL plays a critical and unique role in the signal-induced regulation of CD45 (show PTPRC Proteins) and demonstrate the utility of cell-based screens for the identification of novel splicing regulatory factors.

Mouse (Murine) Heterogeneous Nuclear Ribonucleoprotein L-Like (HNRPLL) interaction partners

  1. We identify similar patterns of hnRNPLL-induced differential intron retention flanking alternative exons in 14 other genes, representing novel elements of the hnRNPLL-induced splicing program in T cells.

  2. Data indicate that the RNA-binding protein hnRNPLL has a critical role in tuning transcriptomes of terminally differentiating B lymphocytes.

  3. The splicing factor hnRNPLL and the transcription elongation factor ELL2 modulate the ratio of secred versus membrane-encoding Ighg2b transcripts at the expense of the secreted isoform.

  4. results highlight both overlapping and divergent roles for hnRNPLL between conventional T cells and NKT (show CTSL1 Proteins) cells

  5. In T cells with no CD45 (show PTPRC Proteins) protein, hnRNPLL mutation diminishes peripheral T cell accumulation and demonstrates that hnRNPLL regulates T cell longevity independently from its effects on CD45 (show PTPRC Proteins) splicing.

  6. A single substitution in a memory-induced RNA-binding protein, hnRNPLL, destabilized an RNA-recognition domain that bound with micromolar affinity to RNA containing the Ptprc (show PTPRC Proteins) exon-silencing sequence.

Heterogeneous Nuclear Ribonucleoprotein L-Like (HNRPLL) Protein Profile

Protein Summary

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC\; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008

Gene names and symbols associated with HNRPLL

  • heterogeneous nuclear ribonucleoprotein L-like (HNRPLL)
  • heterogeneous nuclear ribonucleoprotein L-like (hnrpll)
  • heterogeneous nuclear ribonucleoprotein L-like (LOC100160547)
  • Heterogeneous nuclear ribonucleoprotein L-like (hnrll)
  • heterogeneous nuclear ribonucleoprotein L-like (LOC100338555)
  • heterogeneous nuclear ribonucleoprotein L-like (LOC100638467)
  • heterogeneous nuclear ribonucleoprotein L-like (LOC100647365)
  • heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL)
  • heterogeneous nuclear ribonucleoprotein L-like (Hnrnpll)
  • heterogeneous nuclear ribonucleoprotein L-like (LOC100338135)
  • heterogeneous nuclear ribonucleoprotein L-like (LOC100856681)
  • 2510028H02Rik protein
  • 2810036L13Rik protein
  • AI256697 protein
  • AI852082 protein
  • Hnrpll protein
  • RGD1305861 protein
  • SRRF protein

Protein level used designations for HNRPLL

heterogeneous nuclear ribonucleoprotein L-like , Heterogeneous nuclear ribonucleoprotein L-like , stromal RNA regulating factor , stromal RNA-regulating factor

GENE ID SPECIES
416702 Gallus gallus
470353 Pan troglodytes
100011229 Monodelphis domestica
100054138 Equus caballus
100151733 Xenopus (Silurana) tropicalis
100160547 Acyrthosiphon pisum
100194990 Salmo salar
100338555 Oryctolagus cuniculus
100393835 Callithrix jacchus
100542006 Meleagris gallopavo
100559832 Anolis carolinensis
100638467 Amphimedon queenslandica
100647365 Bombus terrestris
92906 Homo sapiens
475729 Canis lupus familiaris
534315 Bos taurus
72692 Mus musculus
313842 Rattus norvegicus
100338135 Oryctolagus cuniculus
100713480 Cavia porcellus
100622737 Sus scrofa
100856681 Canis lupus familiaris
101119633 Ovis aries
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