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Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) Proteins (HNRNPU)

HNRNPU belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Additionally we are shipping Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) Antibodies (55) and Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HNRNPU 51810 Q8VEK3
Rat HNRNPU HNRNPU 117280  
HNRNPU 3192 Q00839
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Top Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

HNRNPU Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU) Interaction Partners

Mouse (Murine) Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU) interaction partners

  1. findings provide conclusive evidence for the essential role of hnRNP U in heart development and function and in the regulation of alternative splicing.

  2. SAF-A interacts with BRG1 and both components are required for RNA Polymerase II Mediated Transcription

  3. Macrophage expression of hnRNP U was induced by TLR stimulation. hnRNP U knockdown attenuated & overexpression increased TLR-induced expression of TNF-alpha (show TNF Proteins), IL-6 (show IL6 Proteins) & IL-1beta (show IL1B Proteins). hnRNP U bound to the mRNA of these cytokines via the RGG motif.

  4. Data report that endogenous SAF-A is involved in regulation of Oct4 (show POU5F1 Proteins) expression, binds the Oct4 (show POU5F1 Proteins) proximal promoter in ES cells, and dissociates from the promoter upon early differentiation induced by LIF (show LIF Proteins) withdrawal.

  5. hnRNP-U engages a highly neddylated active SCF (show KITLG Proteins)beta-TrCP (show BTRC Proteins)which dissociates in the presence of a high-affinity substrate, resulting in the ubiquitination of the latter.

  6. hnRNP U participates in nuclear regulatory events that are involved in mammalian central and peripheral circadian clocks.

  7. nuclear matrix protein SAF-A binds to the 3'-flanking region of the Bmal1 (show ARNTL Proteins) gene with circadian timing

  8. HnRNP U binding to the 5'-UTR of the Shh (show SHH Proteins) facilitates gene expression during limb development.

  9. SAF-A was found to be localized in three different domains: outside the chromosomes, on the surface of the chromosome arms, and in the centromere region where it apparently binds specifically to the satellite DNA.

  10. the c-Myc (show MYC Proteins)-Max complex exerts its transcriptional regulatory role and hnRNP U may be a coactivator of this transcriptional activator complex.

Human Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU) interaction partners

  1. mutual regulatory mechanisms exist between PP4 (show ANXA5 Proteins) and SAF-A. Interactions between PP4 (show ANXA5 Proteins) and SAF-A played a role in prometaphase/metaphase transition.

  2. CENP-W (show CENPW Proteins) interacts with hnRNPU and may contribute to kinetochore-microtubule attachment in mitotic cells.

  3. Nuclear TDP-43 (show TARDBP Proteins) becomes neurotoxic by escaping from the inhibitory regulation by hnRNP-U or hnRNP (show HNRNPC Proteins)-A2. hnRNP-U inhibits TDP-43 (show TARDBP Proteins)-mediated alterations in splicing of POLDIP3 (show POLDIP3 Proteins) mRNA.

  4. These results suggest that HNRNPU, FAM36A, and NCRNA00201 are not major genes for microcephaly and corpus callosum abnormalities but are good candidates for intellectual disability (ID) and seizures.

  5. both phosphorylation and dephosphorylation of SAF-A serine 59 by PLK1 and PP2A (show PPP2R4 Proteins), respectively, are required for accurate and timely exit from mitosis.

  6. demonstrate that H19 inhibits RNA Pol II-mediated transcription by disrupting the hnRNP U-actin complex

  7. Induction of caspase (show CASP3 Proteins)-9b expression is due to activation of hnRNP L (show HNRNPL Proteins) via phosphorylation to compete/inhibit hnRNP U association with exon 3 of Casp9 (show CASP9 Proteins) mRNA.

  8. the hnRNP-U protection of cells after oxidative stress is largely due to enhancement of NEIL1 (show NEIL1 Proteins)-mediated repair.

  9. experimentally verified the targets heterogeneous nuclear ribonucleoprotein U, phosphatidylinositol-3-OH kinase, the WNK (with-no-lysine) kinase family and USP19 (ubiquitin-specific peptidase 19) as vulnerable nodes in the host cellular defence system against viruses

  10. SAF-A interacts with BRG1 and both components are required for RNA Polymerase II Mediated Transcription

Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU) Protein Profile

Protein Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.

Gene names and symbols associated with HNRNPU

  • heterogeneous nuclear ribonucleoprotein U (Hnrnpu)
  • heterogeneous nuclear ribonucleoprotein U (LOC100348766)
  • heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) (HNRNPU)
  • heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) (hnrnpu)
  • heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) (Hnrnpu)
  • AA408410 protein
  • AI256620 protein
  • AL024194 protein
  • AL024437 protein
  • AW557595 protein
  • C86794 protein
  • hnRNP U protein
  • HNRPU protein
  • saf-a protein
  • SAFA protein
  • SN1 protein
  • Sp120 protein
  • U21.1 protein

Protein level used designations for HNRNPU

SAF-A , heterogenous nuclear ribonucleoprotein U , nuclear matrix protein sp120 , scaffold attachment factor A , system N1 Na+ and H+-coupled glutamine transporter , transporter protein , transporter protein; system N1 Na+ and H+-coupled glutamine transporter , heterogeneous nuclear ribonucleoprotein U , p120 nuclear protein , pp120

GENE ID SPECIES
51810 Mus musculus
117280 Rattus norvegicus
100348766 Oryctolagus cuniculus
3192 Homo sapiens
399374 Xenopus laevis
539950 Bos taurus
100515571 Sus scrofa
421492 Gallus gallus
100725944 Cavia porcellus
101107118 Ovis aries
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