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Expression of HEXIM1 is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. Additionally we are shipping HEXIM1 Proteins (14) and HEXIM1 Kits (6) and many more products for this protein.
Showing 10 out of 127 products:
Human Polyclonal HEXIM1 Primary Antibody for EIA, IHC (p) - ABIN952725
Dow, Liu, Rice: T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes. in Journal of cellular physiology 2010
Show all 4 references for ABIN952725
Human Polyclonal HEXIM1 Primary Antibody for IHC (p), WB - ABIN657913
Ogba, Doughman, Chaplin, Hu, Gargesha, Watanabe, Montano: HEXIM1 modulates vascular endothelial growth factor expression and function in breast epithelial cells and mammary gland. in Oncogene 2010
Show all 3 references for ABIN657913
Mouse (Murine) Polyclonal HEXIM1 Primary Antibody for IHC (p), WB - ABIN655589
Schönichen, Bigalke, Urbanke, Grzesiek, Dames, Geyer: A flexible bipartite coiled coil structure is required for the interaction of Hexim1 with the P-TEFB subunit cyclin T1. in Biochemistry 2010
Show all 3 references for ABIN655589
Human Polyclonal HEXIM1 Primary Antibody for ELISA, WB - ABIN188667
Schulte, Czudnochowski, Barboric, Schönichen, Blazek, Peterlin, Geyer: Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat. in The Journal of biological chemistry 2005
Cow (Bovine) Polyclonal HEXIM1 Primary Antibody for WB - ABIN2775783
Yik, Chen, Nishimura, Jennings, Link, Zhou: Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. in Molecular cell 2003
Suggest that greater tumor associated macrophage density, strong Hexim1 expression, strong SMAD2 (show SMAD2 Antibodies) expression, and mild SMAD7 (show SMAD7 Antibodies) expression play important roles in the progression of prostate adenocarcinoma.
Results show that HEXIM1 is a tumor suppressor in melanoma that responds to nucleotide stress by inhibiting transcription elongation of tumorigenic genes and stabilizing mRNA transcripts of other tumor suppressor genes.
Data indicate the binding of RNA-binding protein (show PTBP1 Antibodies) HEXIM with 7SKsnRNP complex comprising the non-coding RNA 7SK and proteins MePCE (show MEPCE Antibodies) and LARP7 (show LARP7 Antibodies).
PPM1G (show PPM1G Antibodies) phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb (show CCNT1 Antibodies) has been released from the 7SK snRNP (show LSM2 Antibodies).
This study demonstrates a novel role of HEXIM1 in regulating human pluripotent stem cells fate through a P-TEFb (show CCNT1 Antibodies)-independent pathway.
HEXIM1 functions as an AR (androgen receptor (show AR Antibodies)) co-repressor as it physically interacts with the AR and is required for the ability of anti-androgens to inhibit androgen-induced target gene expression and cell proliferation.
the release of P-TEFb (show CCNT1 Antibodies) from the 7SK snRNP (show LSM2 Antibodies) led to increased synthesis of HEXIM1 but not HEXIM2 (show HEXIM2 Antibodies)
There is evidence for a direct interaction between HIF-1alpha (show HIF1A Antibodies) and HEXIM1, and HEXIM1 up-regulated hydroxylation of HIF-1alpha (show HIF1A Antibodies).
P-TEFb/HEXIM1-dependent transcriptional regulation may play a pathophysiological role in RVH and be a novel therapeutic target for mitigating RVH in PAH
results not only identify HEXIM1 as a positive regulator of p53 (show TP53 Antibodies), but also propose a novel molecular mechanism of p53 (show TP53 Antibodies) activation caused by the anti-cancer drugs and compounds.
The authors demonstrate that bovine hexamethylene bisacetamide-induced protein 1 (BHEXIM1) inhibits the bovine immunodeficiency virus-mediated BIV LTR transcription. In vivo and in vitro assays show direct binding of BHEXIM1 to the bovine cyclin T1 (show CCNT1 Antibodies).
Hexim1 selectively modulates leptin (show LEP Antibodies)-mediated signal transduction pathways in the hypothalamus.
conclude that HEXIM1 could prevent RV hypertrophy, at least in part, via suppression of myocardial angiogenesis through down-regulation of HIF-1alpha and VEGF in the myocardium under hypoxic condition
HEXIM1 re-expression results in the induction of angiogenesis that allows for the co-ordination of tissue growth and angiogenesis during physiological hypertrophy
re-expression of HEXIM1 in mammary epithelial cells resulted in inhibition of metastasis to the lung
a crucial role for the HEXIM1/P-TEFb (show CCNT1 Antibodies) pathway in the regulation of satellite cell-mediated muscle regeneration and identify HEXIM1 as a potential therapeutic target for degenerative muscular diseases.
Our findings underscore the critical role of CLP-1 in remodeling of the genetic response during hypertrophy and fibrosis.
these results show that the improvement in cardiac function in CLP-1(+/-) mice after ischemia-reperfusion injury is achieved through the potentiation of redox signaling.
CLP-1 and the HAND transcription factors may be part of a genetic program critical to proper heart development, and their perturbation can lead to cardiomyopathy
HEXIM1 plays critical roles in coronary vessel development and myocardial growth
the reduced level of CLP-1 introduced in the background of elevated levels of cyclin T1 (show CCNT1 Antibodies) elevates derepression of P-TEFb (show CCNT1 Antibodies) activity and emphasizes the importance of the role of CLP-1 in the mechanism governing compensatory hypertrophy in cardiomyocytes.
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.
hexamethylene bis-acetamide inducible 1
, protein HEXIM1
, protein HEXIM1-like
, protein HEXIM
, cardiac lineage protein 1
, estrogen down-regulated gene 1 protein
, hexamethylene bis-acetamide-inducible protein 1
, hexamethylene bisacetamide-inducible protein
, hexamethylene-bis-acetamide-inducible transcript 1
, hexamthylene bis-acetamide inducible 1
, menage a quatre 1
, menage a quatre protein 1
, HMBA-inducible 1