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Expression of HEXIM1 is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. Additionally we are shipping HEXIM1 Antibodies (132) and HEXIM1 Kits (6) and many more products for this protein.
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Identify a HEXIM1-containing ribonuclear protein complex composed also of DNA-PK, paraspeckle subunits, and the long non-coding RNA (lncRNA) NEAT1, which acts as a key nuclear regulator of DNA-mediated activation of innate immune response through the cGAS-STING pathway.
HMBA and derivative HMBA4a1 induce HEXIM1 activity, targeting several signaling pathways critical in tumorigenesis and metastasis.
HSP70 (show HSP70 Proteins) activator shows similar activity as HMBA and 4a1 to induce HEXIM1 expression, suggesting that HMBA and 4a1 might be putative HSP70 (show HSP70 Proteins) activators
Our results demonstrated that HEXIM1 exhibited the most consistent response to BET inhibitors in all of the settings examined, including tumors and surrogate tissues.
Suggest that greater tumor associated macrophage density, strong Hexim1 expression, strong SMAD2 (show SMAD2 Proteins) expression, and mild SMAD7 (show SMAD7 Proteins) expression play important roles in the progression of prostate adenocarcinoma.
Results show that HEXIM1 is a tumor suppressor in melanoma that responds to nucleotide stress by inhibiting transcription elongation of tumorigenic genes and stabilizing mRNA transcripts of other tumor suppressor genes.
Data indicate the binding of RNA-binding protein (show PTBP1 Proteins) HEXIM with 7SKsnRNP complex comprising the non-coding RNA 7SK and proteins MePCE (show MEPCE Proteins) and LARP7 (show LARP7 Proteins).
PPM1G (show PPM1G Proteins) phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb (show CCNT1 Proteins) has been released from the 7SK snRNP (show LSM2 Proteins).
This study demonstrates a novel role of HEXIM1 in regulating human pluripotent stem cells fate through a P-TEFb (show CCNT1 Proteins)-independent pathway.
HEXIM1 functions as an AR (androgen receptor (show AR Proteins)) co-repressor as it physically interacts with the AR and is required for the ability of anti-androgens to inhibit androgen-induced target gene expression and cell proliferation.
The authors demonstrate that bovine hexamethylene bisacetamide-induced protein 1 (BHEXIM1) inhibits the bovine immunodeficiency virus-mediated BIV LTR transcription. In vivo and in vitro assays show direct binding of BHEXIM1 to the bovine cyclin T1 (show CCNT1 Proteins).
Decreased Hexim-1 expression does not alter cholesterol metabolism in ApoE (show APOE Proteins) null background after high fat diet. However, it promotes stable atherosclerotic plaque and decreased steatosis by promoting the anti-inflammatory TGFbeta (show TGFB1 Proteins) pathway and blocking the expression of the inducible and pro-inflammatory expression of SOCS3 (show SOCS3 Proteins) respectively.
Hexim1 selectively modulates leptin (show LEP Proteins)-mediated signal transduction pathways in the hypothalamus.
conclude that HEXIM1 could prevent RV hypertrophy, at least in part, via suppression of myocardial angiogenesis through down-regulation of HIF-1alpha and VEGF in the myocardium under hypoxic condition
HEXIM1 re-expression results in the induction of angiogenesis that allows for the co-ordination of tissue growth and angiogenesis during physiological hypertrophy
re-expression of HEXIM1 in mammary epithelial cells resulted in inhibition of metastasis to the lung
a crucial role for the HEXIM1/P-TEFb (show CCNT1 Proteins) pathway in the regulation of satellite cell-mediated muscle regeneration and identify HEXIM1 as a potential therapeutic target for degenerative muscular diseases.
Our findings underscore the critical role of CLP-1 (show CNNM1 Proteins) in remodeling of the genetic response during hypertrophy and fibrosis.
these results show that the improvement in cardiac function in CLP-1 (show CNNM1 Proteins)(+/-) mice after ischemia-reperfusion injury is achieved through the potentiation of redox signaling.
CLP-1 (show CNNM1 Proteins) and the HAND transcription factors may be part of a genetic program critical to proper heart development, and their perturbation can lead to cardiomyopathy
HEXIM1 plays critical roles in coronary vessel development and myocardial growth
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.
hexamethylene bis-acetamide inducible 1
, protein HEXIM1
, protein HEXIM1-like
, protein HEXIM
, cardiac lineage protein 1
, estrogen down-regulated gene 1 protein
, hexamethylene bis-acetamide-inducible protein 1
, hexamethylene bisacetamide-inducible protein
, hexamethylene-bis-acetamide-inducible transcript 1
, hexamthylene bis-acetamide inducible 1
, menage a quatre 1
, menage a quatre protein 1
, HMBA-inducible 1