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anti-Hexosaminidase A (HEXA) Antibodies

HEXA encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Additionally we are shipping Hexosaminidase A Kits (34) and Hexosaminidase A Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HEXA 15211 P29416
HEXA 300757 Q641X3
HEXA 3073 P06865
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Top anti-Hexosaminidase A Antibodies at antibodies-online.com

Showing 10 out of 107 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB (LEFT) Western blot analysis of HEXA Antibody (N-term) in HepG2 cell line lysates (35 µg/lane). HEXA (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of HEXA Antibody (N-term) in mouse liver tissue lysates (35 µg/lane). HEXA (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of HEXA Antibody (Center) in HepG2 cell line lysates (35ug/lane). HEXA (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of HEXA Antibody (N-term) (ABIN390929) in HepG2 cell line lysates (35 µg/lane). HEXA (arrow) was detected using the purified polyclonal antibody. Western blot analysis of HEXA Antibody (N-term) (ABIN390929) in mouse liver tissue lysates (35 µg/lane). HEXA (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of HEXA Antibody (Center) (ABIN652263) in HepG2 cell line lysates (35 µg/lane). HEXA (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with HEXA Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated EIA, FACS, WB 0.1 mg Log in to see 6 to 8 Days
$423.50
Details
Human Mouse Un-conjugated FACS, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of HeLa cells using HEXA mouse mAb (green) and negative control (red) . 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemistry with Brain, cortex tissue at an antibody concentration of 5µg/ml using anti-HEXA antibody (ARP61100_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- HEXA antibody,  Western blotting All lanes: Anti HEXA () at 0.5ug/ml Lane 1: Human Placenta Tissue Lysate at 50ug Lane 2: HELA Whole Cell Lysate at 40ug Lane 3: HEPG2 Whole Cell Lysate at 40ug Lane 4: U87 Whole Cell Lysate at 40ug Predicted bind size: 61KD Observed bind size: 61KD Anti-HEXA antibody, IHC(P) IHC(P):Human Intestinal Cancer Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-HEXA antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN958990 concentration 5 ug/ml. 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details

HEXA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Hexosaminidase A Antibodies

  1. Human Monoclonal Hexosaminidase A Primary Antibody for FACS, ELISA - ABIN969526 : Olszewska, Borzym-Kluczyk, Rzewnicki, Rutkowska, Knas, Rogowski, Waniewska, Wielgosz: Hexosaminidase as a new potential marker for larynx cancer. in Clinical biochemistry 2009 (PubMed)
    Show all 2 references for ABIN969526

  2. Human Monoclonal Hexosaminidase A Primary Antibody for EIA, FACS - ABIN1105521 : Park, Morgan, Sharma, Li, Lobo, Redman, Salazar, Sun, Neidich, Strom: Improving accuracy of Tay Sachs carrier screening of the non-Jewish population: analysis of 34 carriers and six late-onset patients with HEXA enzyme and DNA sequence analysis. in Pediatric research 2010 (PubMed)
    Show all 2 references for ABIN1105521

  3. Human Polyclonal Hexosaminidase A Primary Antibody for FACS, IHC (p) - ABIN390929 : Pennybacker, Liessem, Moczall, Tifft, Sandhoff, Proia: Identification of domains in human beta-hexosaminidase that determine substrate specificity. in The Journal of biological chemistry 1996 (PubMed)

More Antibodies against Hexosaminidase A Interaction Partners

Mouse (Murine) Hexosaminidase A (HEXA) interaction partners

  1. Neu4 (show NEU4 Antibodies) is not the only sialidase contributing to the metabolic bypass in Hexa(-/-) mice.

Human Hexosaminidase A (HEXA) interaction partners

  1. reports a new missense mutation in the HEXA gene in two German siblings with late-onset Tay-Sachs disease and prominent psychiatric symptoms

  2. The silencing of the HEXA gene had a stronger immune inhibitory effect, thereby indicating a major involvement of beta-N-acetyl-hexosaminidase A isoenzyme within this mechanism.

  3. Human prostate cancer cells are characterised by a significant decrease in HexA activity.

  4. DNA reveals novel mutations in Iranian subjects causing Tay-Sachs disease in the alpha and beta subunits of HexA.

  5. GM2 (show CYB5D2 Antibodies) gangliosidosis is caused by the gene mutation. (review)

  6. identified 27 different mutations, 14 of which were novel, in the HEXA gene and 14 different mutations, 8 of which unreported until now, in the HEXB (show HEXB Antibodies) gene, and attempted to correlate these mutations with the clinical presentation of the patients

  7. HEXA gene in Argentinean patients affected with Tay-Sachs disease, overall 14 different mutations were identified, 8 of them were novel and lead to premature stop codons, drastic residues changes or a splicing defect.

  8. Beta-hexosaminidase over-expression affects lysosomal glycohydrolases expression and glycosphingolipid metabolism in mammalian cells.

  9. We report the first Jordanian Arab Tay-Sachs disease patient diagnosed by deficient beta-hexosaminidase A activity, mutation analysis revealed homozygosity for a nonsense HEXA mutation, c.78G>A (p.W26X)

  10. Down-regulation of beta-N-acetyl-D-glucosaminidase increases Akt1 (show AKT1 Antibodies) activity in thyroid anaplastic cancer cells

Cow (Bovine) Hexosaminidase A (HEXA) interaction partners

  1. SNPs in the HEXA region on chromosome 10 have a protective effect against Bovine spongiform encephalopathy.

Hexosaminidase A (HEXA) Antigen Profile

Protein Summary

This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).

Gene names and symbols associated with anti-Hexosaminidase A (HEXA) Antibodies

  • hexosaminidase A (alpha polypeptide) (HEXA) antibody
  • hexosaminidase A (alpha polypeptide) (hexa) antibody
  • hexosaminidase A (LOC100228061) antibody
  • hexosaminidase A (Hexa) antibody
  • DKFZp459O0432 antibody
  • fc04h11 antibody
  • Hex-1 antibody
  • HEXA antibody
  • si:dkey-35i22.2 antibody
  • TSD antibody
  • wu:fc04h11 antibody
  • wu:fv09f06 antibody

Protein level used designations for anti-Hexosaminidase A (HEXA) Antibodies

beta-hexosaminidase subunit alpha , beta-hexosaminidase subunit beta , beta-hexosaminidase alpha chain , hexosaminidase A (alpha polypeptide) , beta-hexosaminidase alpha-subunit , hexosaminidase A , Beta-hexosaminidase alpha chain , N-acetyl-beta-glucosaminidase subunit alpha , beta-N-acetylhexosaminidase subunit alpha , hexosaminidase subunit A , Hexose aminidase A (alpha polypeptide) , hexosaminidase A alpha

GENE ID SPECIES
100145856 Ovis aries
100063584 Equus caballus
323613 Danio rerio
415320 Gallus gallus
748732 Pan troglodytes
100008950 Oryctolagus cuniculus
100302663 Pongo abelii
100195429 Salmo salar
100228061 Taeniopygia guttata
15211 Mus musculus
300757 Rattus norvegicus
3073 Homo sapiens
504468 Bos taurus
487633 Canis lupus familiaris
100142664 Sus scrofa
100438794 Pongo abelii
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