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HEXA encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Additionally we are shipping Hexosaminidase A Kits (34) and Hexosaminidase A Proteins (12) and many more products for this protein.
Showing 10 out of 129 products:
Human Monoclonal Hexosaminidase A Primary Antibody for FACS, ELISA - ABIN969526
Olszewska, Borzym-Kluczyk, Rzewnicki, Rutkowska, Knas, Rogowski, Waniewska, Wielgosz: Hexosaminidase as a new potential marker for larynx cancer. in Clinical biochemistry 2009
Show all 2 references for ABIN969526
Human Monoclonal Hexosaminidase A Primary Antibody for EIA, FACS - ABIN1105521
Park, Morgan, Sharma, Li, Lobo, Redman, Salazar, Sun, Neidich, Strom: Improving accuracy of Tay Sachs carrier screening of the non-Jewish population: analysis of 34 carriers and six late-onset patients with HEXA enzyme and DNA sequence analysis. in Pediatric research 2010
Show all 2 references for ABIN1105521
Human Polyclonal Hexosaminidase A Primary Antibody for FACS, IHC (p) - ABIN652263
Pennybacker, Liessem, Moczall, Tifft, Sandhoff, Proia: Identification of domains in human beta-hexosaminidase that determine substrate specificity. in The Journal of biological chemistry 1996
Neu4 (show NEU4 Antibodies) is not the only sialidase contributing to the metabolic bypass in Hexa(-/-) mice.
reports a new missense mutation in the HEXA gene in two German siblings with late-onset Tay-Sachs disease and prominent psychiatric symptoms
The silencing of the HEXA gene had a stronger immune inhibitory effect, thereby indicating a major involvement of beta-N-acetyl-hexosaminidase A isoenzyme within this mechanism.
Human prostate cancer cells are characterised by a significant decrease in HexA activity.
DNA reveals novel mutations in Iranian subjects causing Tay-Sachs disease in the alpha and beta subunits of HexA.
GM2 (show CYB5D2 Antibodies) gangliosidosis is caused by the gene mutation. (review)
identified 27 different mutations, 14 of which were novel, in the HEXA gene and 14 different mutations, 8 of which unreported until now, in the HEXB (show HEXB Antibodies) gene, and attempted to correlate these mutations with the clinical presentation of the patients
HEXA gene in Argentinean patients affected with Tay-Sachs disease, overall 14 different mutations were identified, 8 of them were novel and lead to premature stop codons, drastic residues changes or a splicing defect.
Beta-hexosaminidase over-expression affects lysosomal glycohydrolases expression and glycosphingolipid metabolism in mammalian cells.
We report the first Jordanian Arab Tay-Sachs disease patient diagnosed by deficient beta-hexosaminidase A activity, mutation analysis revealed homozygosity for a nonsense HEXA mutation, c.78G>A (p.W26X)
Down-regulation of beta-N-acetyl-D-glucosaminidase increases Akt1 (show AKT1 Antibodies) activity in thyroid anaplastic cancer cells
SNPs in the HEXA region on chromosome 10 have a protective effect against Bovine spongiform encephalopathy.
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).
beta-hexosaminidase subunit alpha
, beta-hexosaminidase subunit beta
, beta-hexosaminidase alpha chain
, hexosaminidase A (alpha polypeptide)
, beta-hexosaminidase alpha-subunit
, hexosaminidase A
, Beta-hexosaminidase alpha chain
, N-acetyl-beta-glucosaminidase subunit alpha
, beta-N-acetylhexosaminidase subunit alpha
, hexosaminidase subunit A
, Hexose aminidase A (alpha polypeptide)
, hexosaminidase A alpha