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High Mobility Group Box 2 Proteins (HMGB2)

HMGB2 encodes a member of the non-histone chromosomal high mobility group protein family. Additionally we are shipping HMGB2 Antibodies (84) and HMGB2 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HMGB2 3148 P26583
HMGB2 97165 P30681
HMGB2 29395 P52925
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Top HMGB2 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Hi-5 Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
Human Un-conjugated SDS-PAGE with Coomassie Blue Staining Migration assay with 3T3 mouse cells 100 μg Log in to see 19 Days
$409.58
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,504.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,509.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,513.50
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,513.50
Details
HOST_HEK293 Human His tag   50 μg Log in to see 5 Days
$522.50
Details

HMGB2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced HMGB2 Proteins

  1. Human HMGB2 Protein expressed in Hi-5 - ABIN667939 : Bustin, Lehn, Landsman: Structural features of the HMG chromosomal proteins and their genes. in Biochimica et biophysica acta 1990 (PubMed)
    Show all 2 references for ABIN667939

  2. Human HMGB2 Protein expressed in Wheat germ - ABIN1306802 : Wähämaa, Vallerskog, Qin, Lunderius, LaRosa, Andersson, Harris: HMGB1-secreting capacity of multiple cell lineages revealed by a novel HMGB1 ELISPOT assay. in Journal of leukocyte biology 2006 (PubMed)

More Proteins for High Mobility Group Box 2 (HMGB2) Interaction Partners

Human High Mobility Group Box 2 (HMGB2) interaction partners

  1. Lrp1 (show LRP1 Proteins)-antisense directly binds to high-mobility group box 2 (Hmgb2) and inhibits the activity of Hmgb2 to enhance Srebp1a-dependent transcription of Lrp1 (show LRP1 Proteins).

  2. Data show that odulation of RNA helicase DDX18 (show DDX18 Proteins) directly affects growth of tamoxifen-resistant cells, suggesting that it may be a critical downstream effector of the estrogen receptors (ERs) and high mobility group box 2 (HMGB2) complex.

  3. siRNA-mediated silencing of HMGB2 increased the sensitivity of the head and neck squamous cell carcinoma cell lines to cisplatin and 5-fluorouracil.

  4. the combination of a HMGB1+ and HMGB2- expression potentially predicts a poor prognosis in patients with pancreatic ductal adenocarcinoma

  5. This study found that single nucleotide polymorphisms of HMGB1 (show HMGB1 Proteins) may serve as potential biomarkers for predicting the efficacy of platinum-based chemotherapy.

  6. The present data suggest that HMGB2 expression is a significant prognostic factor for glioblastoma and might play an important role in cell invasion.

  7. HMGB2 is necessary to protect colorectal cancer cells from DNA damage and efficient DNA repair and p53-mediated downregulation is a critical mechanism of modulating HMGB2 expression.

  8. Transient local HMGB2-DNA contacts dominate the DNA-bending mechanism used by HMGB (show FAH Proteins) proteins to increase DNA flexibility.

  9. Crohn's disease in the colon and ulcerative colitis can be differentially diagnosed using anti-HMGB/HMGB2 antibodies combined with anti-Saccharomyces cerevisiae antibodies.

  10. The age-related loss of HMGB2 in articular cartilage may represent a mechanism responsible for the decline in adult cartilage stem cell populations.

Mouse (Murine) High Mobility Group Box 2 (HMGB2) interaction partners

  1. Lrp1 (show LRP1 Proteins)-antisense directly binds to high-mobility group box 2 (Hmgb2) and inhibits the activity of Hmgb2 to enhance Srebp1a-dependent transcription of Lrp1 (show LRP1 Proteins).

  2. HMGB2 functions as a modulator of neurogenesis in young adult mice through regulation of neural stem cell proliferation.

  3. Oct4 post-translational modifications (PTMs) form a positive feedback loop, which promotes Akt activation and interaction with Hmgb2 and the SET complex.

  4. HMGB2 (but not HMGB1 (show HMGB1 Proteins)) suppresses pathologic cell growth in vivo and controls a gene expression program responsible for hypertrophic cell growth

  5. The age-related loss of HMGB2 in articular cartilage may represent a mechanism responsible for the decline in adult cartilage stem cell populations.

  6. Data show that Hmgb1 and Hmgb2 function redundantly to enhance Wnt signaling in embryos, and further suggest that integrating Wnt, Shh, and BMP signaling regulates the development of digit5 in forelimbs.

  7. High levels of HMGB2 directly correlate with the extent of neoplastic changes in cutaneous squamous cell carcinoma. HMGB2 is an effective stimulus for cell differentiation, tumor progression, & metastatic invasion.

  8. In human and murine cartilage, there is an aging-related loss of HMGB2 expression, ultimately leading to its complete absence.

  9. Increased HMGB2 expression is associated with squamous cell carcinoma of skin.

  10. an interaction between HMGB2 and the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway regulates the maintenance of the superficial zone

HMGB2 Protein Profile

Protein Summary

This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.

Gene names and symbols associated with HMGB2

  • high-mobility group box 2 (LOC100356612)
  • high mobility group box 2 (HMGB2)
  • high mobility group box 2 (hmgb2)
  • high mobility group box 2 (Hmgb2)
  • C80539 protein
  • HMG-2 protein
  • Hmg2 protein

Protein level used designations for HMGB2

high-mobility group box 2 , HMG-2 , high mobility group protein 2 , high mobility group protein B2 , high-mobility group (nonhistone chromosomal) protein 2 , non-histone chromosomal protein , non-histone protein HMG2

GENE ID SPECIES
100356612 Oryctolagus cuniculus
3148 Homo sapiens
379074 Xenopus laevis
396482 Gallus gallus
486068 Canis lupus familiaris
397130 Sus scrofa
540444 Bos taurus
97165 Mus musculus
29395 Rattus norvegicus
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